- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00004326
Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome
OBJECTIVES: I. Evaluate whether chronic hypercortisolemia is specifically toxic to hippocampal cells and causes structural reduction of hippocampal volume in patients with Cushing's syndrome.
II. Determine whether reduced hippocampal volume is associated with specific memory dysfunction.
III. Examine the relationships of adrenal androgen to hippocampal volume and memory dysfunction.
IV. Examine the reversibility of hippocampal structural changes and cognitive dysfunction after cortisol levels are normalized.
Study Overview
Status
Conditions
Detailed Description
PROTOCOL OUTLINE: Patients undergo a psychiatric evaluation for mood and cognition during confirmation of diagnosis. Neuropsychologic exams include pencil and paper test and a cognitive assessment.
Endocrine studies include dexamethasone and corticotropin-releasing hormone stimulation tests. The hippocampal complex volume is assessed with coronal magnetic resonance imaging.
There is a follow-up 1 year after the initiation of treatment.
Study Type
Enrollment
Contacts and Locations
Study Locations
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Michigan
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Ann Arbor, Michigan, United States, 48109
- University of Michigan Health Systems
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
PROTOCOL ENTRY CRITERIA:
- Adults and teenagers with untreated, spontaneous active Cushing's syndrome
- Diagnosis verified at the University of Michigan Medical Center, including the following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol secretion rate, and plasma cortisol level
- Lack of normal circadian cortisol secretion and failure to suppress following 2 mg of dexamethasone
Study Plan
How is the study designed?
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Monica N. Starkman, University of Michigan
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 199/11872
- UMMC-1043
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