- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00004353
Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia
OBJECTIVES: I. Study the metabolism of pyruvate and related problems in patients with lactic acidemia.
II. Define the nature of the metabolic defect.
Study Overview
Status
Conditions
Detailed Description
PROTOCOL OUTLINE: Patients fast for 6 hours. Glucagon IM is administered after the 6 hour fast. Glucose level is measured at 0, 15, 30, 45, 60, and 90 minutes.
In children of sufficient size, alanine and lactic acid should also be measured at each or most of these time points.
Fasting continues for at least 18 hours. Glucagon IM is administered again at end of fast. Glucose level is measured at time 0, 15, 30, 45, 60, and 90 minutes.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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California
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San Diego, California, United States, 92103-8757
- University of California San Diego Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
PROTOCOL ENTRY CRITERIA:
- Diagnostically documented elevation in lactate, pyruvate, and/or alanine levels in lactic acidemia patients
Study Plan
How is the study designed?
Collaborators and Investigators
Collaborators
Investigators
- Study Chair: Richard H. Haas, University of California, San Diego
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Metabolic Diseases
- Cerebrovascular Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Genetic Diseases, Inborn
- Musculoskeletal Diseases
- Neuromuscular Diseases
- Metabolism, Inborn Errors
- Brain Diseases, Metabolic
- Mitochondrial Diseases
- Brain Diseases, Metabolic, Inborn
- Cerebral Small Vessel Diseases
- Acid-Base Imbalance
- Mitochondrial Encephalomyopathies
- Muscular Diseases
- Mitochondrial Myopathies
- MELAS Syndrome
- Acidosis
- Acidosis, Lactic
Other Study ID Numbers
- NCRR-M01RR00827-0071
- UCSD-071
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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