Minneapolis Children's Blood Pressure Study

To examine environmental and familial correlates of childhood blood pressure in order to predict elevated blood pressure in young adulthood. Also, to investigate the phenomena of tracking of blood pressure and obesity from childhood to young adulthood.

Study Overview

Detailed Description

BACKGROUND:

Hypertension has been clearly identified as a major risk factor for coronary heart disease and stroke. Hypertension screening and intervention programs for children are based on the concept that high normal blood pressure may be the childhood antecedent of adult hypertension or that blood pressure 'tracks' through childhood, adolescence, and adulthood. Blood pressure tracking has been well established for adults and young adults but results from various studies in children are controversial. At a Symposium on High Blood Pressure in the Young in 1979, it was concluded that there was insufficient information to recommend specific interventions for prepubertal children with blood pressure levels in the upper percentiles of the blood pressure distribution. Studies of longer duration with large population sizes and repeated blood pressure measurements over time were required to determine if blood pressure levels at these young ages were predictive of adult hypertension.

DESIGN NARRATIVE:

In the Spring of 1978 a total of 10,423 children, ages 6-8 were screened. A subsample was invited to join the study of blood pressure measurement. The sample was selected as follows: all children in the top five percent of the initial systolic blood pressure distribution; all children in the bottom five percent of the initial systolic blood pressure distribution; a random sample of one in two of the remaining Black children; a random sample of one in nine of the remaining white children; and all the remaining children of other races. Included were families of about 200 Native American children. Of 2,641 selected children, 878 refused leaving a sample of 1,753. Baseline data on age, race, sex, triceps skinfold thickness, dietary history, urinary sodium and potassium excretion, physiological measures, life event changes, medical history, demographic data and body size measurements of children and their parents were collected at the first home interview conducted between 1978 and 1979. The children were followed twice per year in 1978 to 1980 and 1982 to 1985 for blood pressure and body size. Annual measurements were made of blood pressure, height, weight, skinfold thickness, and body girths. Screenings continued through early 1991 when the cohort was 19-21 years of age.

Several substudies were conducted including the relationship of red blood cell cation transport to essential hypertension, Type A behavior assessments, and familial aggregation of coronary-prone behavior.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Study Type

Observational

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

No older than 100 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

No eligibility criteria

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Collaborators and Investigators

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Publications and helpful links

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General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 1977

Study Completion (Actual)

May 1, 1997

Study Registration Dates

First Submitted

May 25, 2000

First Submitted That Met QC Criteria

May 25, 2000

First Posted (Estimate)

May 26, 2000

Study Record Updates

Last Update Posted (Estimate)

May 13, 2016

Last Update Submitted That Met QC Criteria

May 12, 2016

Last Verified

June 1, 2000

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1012
  • R01HL019877 (U.S. NIH Grant/Contract)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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