- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00013949
Cardiovascular Vulnerability to Particulate Exposure
September 1, 2006 updated by: National Institute of Environmental Health Sciences (NIEHS)
Active Elderly Study
This project is part of a program project directed toward assessing cardiac effects of particulate and other ambient air pollutants.
In this project active elderly adults living in the communities of Boston and Steubenville have attended 12 weekly sessions including approximately 40 minutes of Holter monitoring, blood pressure, and oximetry evaluation before, during, and after outdoor exercise.
To investigate the relation of air pollution to cardiac and pulmonary rehabilitation, a second portion of this study involves abstraction of blood pressure and symptom data and downloading of available repeated measures telemetry data in two populations.
These populations include: 1) 200 outpatients attending 8 to 36 repeated weekly exercise training sessions in a major hospital cardiac rehabilitation unit.
Study Overview
Status
Completed
Conditions
Detailed Description
Approximately 60 subjects have participated fully in Boston and Steubenville in the repeated 40 minute measurement of continuous EKG (Holter), blood pressure, and oximetry.
In Steubenville we have also measured exhaled nitrogen oxide, an index of pulmonary inflammation.
The exposure monitoring has included outdoor particle mass of PM2.5, outdoor gaseous pollutants, and indoor home and personal monitoring to evaluate the indoor contribution of pollution to health effects.
Study Type
Observational
Enrollment
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Massachusetts
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Boston, Massachusetts, United States, 02115
- Brigham and Women's Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years to 90 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Participants are 50 to 90 years of age, but almost all are 60 and older.
They have been enrolled as volunteers from communities in Mission Park, Boston, and Steubenville.
Inclusion criteria includes the ability to walk on level ground.
Exclusion criteria includes unstable anginal, and baseline EKG patterns such as left bundle branch block that would make difficult the detection of repolarization abnormalities.
Participants live at or near the study center which was located in an office or apartment in the apartment building of the majority of the participants.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Defined Population
- Time Perspectives: Prospective
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Director: Diane Gold, MD, Harvard School of Public Health (HSPH)
- Principal Investigator: Frank E Speizer, MD, Harvard School of Public Health (HSPH)
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 1998
Study Completion
September 1, 2004
Study Registration Dates
First Submitted
April 3, 2001
First Submitted That Met QC Criteria
April 3, 2001
First Posted (Estimate)
April 4, 2001
Study Record Updates
Last Update Posted (Estimate)
September 4, 2006
Last Update Submitted That Met QC Criteria
September 1, 2006
Last Verified
September 1, 2006
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9825-CP-003
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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