South Danish Diabetes Study: Evaluation of the Antidiabetic Treatment of Type 2 Diabetes Mellitus

South Danish Diabetes Study: A Prospective Randomised Multi-Centre Study for the Evaluation of the Optimal Pharmacological Antidiabetic Treatment of Type 2 Diabetes Mellitus

Sponsors

Lead Sponsor: Odense University Hospital

Source Odense University Hospital
Brief Summary

The primary objective of this study is:

- To investigate whether insulin aspart with meals is better than a standard treatment with insulin NPH at bedtime, evaluated by HbA1c.

The secondary objectives of this study are:

- To study if a combination treatment with metformin and/or rosiglitazone and insulin aspart with meals is better than a standard treatment with insulin NPH combined with one or more of the above oral antidiabetic drugs. According to the hypothesis, special focus will be given to the treatment group with insulin aspart combined with metformin and rosiglitazone. The treatment effect will be evaluated by HbA1c.

- To examine the effects of the treatments on glucose metabolism and beta cell function, evaluated by diurnal blood glucose, fasting plasma glucose, insulin, C-peptide, and lactate.

- To examine the effects of the treatments on cardiovascular risk factors evaluated by serum lipid profiles, serum free fatty acids, urine albumin/creatinine ratio, and electrocardiogram (ECG).

- To quantify and describe the patients' subjective experiences of the two different insulin treatments (quality of life assessment)

- To examine patients with type 2 diabetes for the presence of variability in a series of genes, which are known to or are assumed to:

- affect the long term outcome;

- determine the responsiveness to treatment with diet, exercise and drugs targeting the known risk markers for late diabetic complications; and

- after intervention, to analyse the complex interrelationships between genotypes and clinical endpoints and the responsiveness to actual treatment modalities.

Overall Status Completed
Start Date January 2003
Completion Date July 2007
Primary Completion Date July 2007
Phase Phase 4
Study Type Interventional
Primary Outcome
Measure Time Frame
HbA1c following two years of treatment
Secondary Outcome
Measure Time Frame
body weight
blood pressure
fasting blood glucose
diurnal blood glucose profiles (self monitored and continuously monitored)
fasting cholesterol (including HDL, LDL, and triglyceride)
free fatty acids
lactate
fasting insulin, proinsulin-C-peptide
urine glucose
urine albumin/creatinine ratio
Enrollment 400
Condition
Intervention

Intervention Type: Drug

Intervention Name: Insulin Aspart

Intervention Type: Drug

Intervention Name: Insulin NPH

Intervention Type: Drug

Intervention Name: Metformin

Intervention Type: Drug

Intervention Name: Rosiglitazone

Eligibility

Criteria:

Inclusion Criteria:

- Ages between 30 and 70 years

- Fasting C-peptide >300 pmol/l

- Body mass index (BMI) > 25 kg/m2

- Diabetes for more than 2 years

- Pharmacological antidiabetic treatment for more than 3 months

- 7.0%

- Patient willing to sign informed consent

- Fertile women: negative pregnancy test and use of oral or intra-uterine contraception or depot gestagen.

Exclusion Criteria:

- S-creatinine > 120 μmol/l

- History of intolerance to metformin or glitazones

- S-ALAT/S-ASAT > 2.5 x upper normal limit

- Total cholesterol > 10 mmol/l

- Total triglyceride > 8 mmol/l

- Hemoglobin (Hb) < normal range

- Treatment with glitazone preceding 30 days New York Heart Association (NYHA) functional class III or IV

- Night work

- Present or planned pregnancy

- Poor vision impeding insulin administration

- Unawareness of hypoglycaemia (complete or partly)

- Mental illness or alcohol abuse

- Clinically relevant major organ or systemic illness

- Uncontrolled hypertension >180/110 mmHg, systolic or diastolic

- Steroid treatment

- Severe lung disease

- A history of malign disease

- An expectation that the patient will not be collaborative or will not be able to understand the character of this trial

Gender: All

Minimum Age: 30 Years

Maximum Age: 70 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Jeppe Gram, MD, PhD Principal Investigator Esbjerg Hospital
Location
Facility: Diabetes Research Center
Location Countries

Denmark

Verification Date

June 2008

Responsible Party

Name Title: Jeppe Gram/MD

Organization: Ribe County Hospital, Esbjerg, Denmark

Keywords
Has Expanded Access No
Condition Browse
Acronym SDDS
Study Design Info

Allocation: Randomized

Intervention Model: Factorial Assignment

Primary Purpose: Treatment

Masking: Double

Source: ClinicalTrials.gov