- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00173342
Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization
Study Overview
Status
Conditions
Detailed Description
The EKG pattern and medical records from the school survey from 1999 to 2002 in Taipei city will be reviewed, and the basic data of those with CRBBB, IRBBB and rsR' pattern will be recorded. Interview will be made and the echocardiographic measurements will be performed to identify associated cardiac defects. EKG parameters and QT, QTc, QT dispersion, QTc dispersion and HRV parameters will be obtained from a semi-automated system. Time domain and frequency domain measures will be calculated and expressed as SDNN, triangular index, SDNN index, total power, low frequency power and high frequency power. Mutational analysis and DNA sequencing will be conducted in those with CRBBB or Brugada pattern EKG, especially those with positive family history.
Based on these data, the clinical significance of altered bundle branch conduction identified from a school survey may be defined. For those with isolated CRBBB or IRBBB, the adjunctive value of HRV and QT parameters will determined the high risk group, and 24 hour Holter recording and Treadmill exercise test will then perform in these patients to define association with ventricular arrhythmia.
Study Type
Enrollment
Contacts and Locations
Study Contact
- Name: Mei-Hwan Wu, MD, PhD
- Phone Number: 5126 886-2-23123456
- Email: mhwu@ha.mc.ntu.edu.tw
Study Contact Backup
- Name: Shuenn-Nan Chiu, MD
- Phone Number: 5126 886-2-23123456
- Email: michael@ha.mc.ntu.edu.tw
Study Locations
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-
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Taipei, Taiwan, 100
- Recruiting
- Department of Pediatrics, National Taiwan University Hospital
-
Contact:
- Mei-Hwan Wu, MD, PhD
- Phone Number: 5126 886-2-23123456
- Email: mhwu@ha.mc.ntu.edu.tw
-
Contact:
- Shuenn-Nan Chiu, MD
- Phone Number: 5126 886-2-23123456
- Email: michael@ha.mc.ntu.edu.tw
-
Taipei, Taiwan, 100
- Recruiting
- Pediatric Department, National Taiwan University Hospital
-
Contact:
- Mei-Hwan Wu, MD, PhD
- Phone Number: 5126 886-2-23123456
- Email: mhwu@ha.mc.ntu.edu.tw
-
Contact:
- Shuenn-Nan Chiu, MD
- Phone Number: 5126 886-2-23123456
- Email: michael@ha.mc.ntu.edu.tw
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- ECG showed right bundle branch block
Exclusion Criteria:
- can't tolerate Treadmill ECG study
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Investigators
- Study Chair: Mei-Hwan Wu, MD, PhD, National Taiwan University Hospital
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9461700620
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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