- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00177060
Topical Hydromorphone for Wound Healing
February 26, 2010 updated by: Hordinsky, Maria K., MD
The hypothesis is that topical opioids will hasten wound healing in humans.
Study Overview
Detailed Description
This is based on our published data that morphine is a powerful stimulant of angiogenesis and our preclinical study of wounds in rats which demonstrate that topical opioids (morphine, hydromorphone and fentanyl) hasten healing of punch biopsy wounds.
This study will focus on hydromorphone which was more powerful than morphine as a wound-healer in the rat study.
Study Type
Interventional
Enrollment (Anticipated)
50
Phase
- Phase 2
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Minnesota
-
Minneapolis, Minnesota, United States, 55455
- University of Minnesota
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 63 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Self-identified as normal, healthy volunteers age 18-65.
Exclusion Criteria:
- Known bleeding disorder.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Single Group Assignment
- Masking: Single
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Healing rates and microvessel density will be compared statistically for the control-ointment versus hydromorphone-ointment subjects.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Robert Hebbel, MD, University of Minnesota
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2003
Study Completion (Actual)
May 1, 2007
Study Registration Dates
First Submitted
September 13, 2005
First Submitted That Met QC Criteria
September 13, 2005
First Posted (Estimate)
September 15, 2005
Study Record Updates
Last Update Posted (Estimate)
March 1, 2010
Last Update Submitted That Met QC Criteria
February 26, 2010
Last Verified
February 1, 2010
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 0308M50994
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Wound Healing
-
University of Witten/HerdeckeKCI Europe Holding B.V.CompletedImpaired Wound Healing | Wound Healing Disorder | Abdominal Wound Healing Disorder | Abdominal Wound Healing Impairment | Acute Postsurgical Subcutaneous WoundBelgium, Germany
-
Universidade Estadual Paulista Júlio de Mesquita...RecruitingWound Healing | Palate; WoundBrazil
-
First Affiliated Hospital, Sun Yat-Sen UniversityRecruiting
-
3MRecruiting
-
Central Hospital, Nancy, FranceNot yet recruiting
-
Riyadh Elm UniversityUnknown
-
Icahn School of Medicine at Mount SinaiTerminated
-
OcuNexus Therapeutics, Inc.Completed
-
Stratpharma AGUniversity Hospital, GenevaCompleted
-
Johnson & Johnson Consumer Inc. (J&JCI)CompletedWound HealingUnited States
Clinical Trials on hydromorphone
-
Mayo ClinicRecruitingPain ControlUnited States
-
Johnson & Johnson Pharmaceutical Research & Development...Completed
-
Brigham and Women's HospitalTerminatedPain | Healthy | PregnancyUnited States
-
Thomas Jefferson UniversityCompleted
-
Shirley Ryan AbilityLabMallinckrodtCompletedLow Back PainUnited States
-
University of British ColumbiaCanadian Institutes of Health Research (CIHR); Providence Healthcare; Innerchange...CompletedHeroin Dependence | Opioid DependenceCanada
-
Fujian Cancer HospitalCompleted
-
Dr. Anthony HoRecruitingPain Control After Elective HepatectomyCanada
-
Mundipharma Research GmbH & Co KGCompletedConstipationRomania, Switzerland, Israel, Belgium, Germany, Australia, Austria, Czech Republic, Denmark, Finland, France, Netherlands, Poland, United Kingdom
-
Nova Scotia Health AuthorityCanadian Institutes of Health Research (CIHR); Nova Scotia Health Research... and other collaboratorsCompletedChronic Obstructive Pulmonary Disease (COPD)Canada