- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00202488
The Effect of H. Pylori Infection on Iron Metabolism
July 29, 2008 updated by: Seattle Institute for Biomedical and Clinical Research
The purpose of this study is to determine if Helicobacter pylori (H.
pylori) gastritis results in abnormal iron metabolism in patients with iron deficiency anemia (IDA), and to determine if this is due to strain variations in the H. pylori organism.
Study Overview
Status
Completed
Intervention / Treatment
Detailed Description
There is suggestive evidence that H. pylori gastritis (without peptic ulcer disease) is a cause of IDA.
There have been individual case reports and case series describing patients with refractory IDA that resolved following successful H. pylori treatment.
The effect of H. pylori on iron metabolism will be studied through specific aims: 1.
To assess whether H. pylori results in abnormal oral iron absorption 2. To assess if differences in H. pylori strains are associated with iron deficiency due to: a. genetic differences in H. pylori strains or b. differences in the pattern of gastritis which could be due to host, bacterial or environmental factors 3. To assess if H. pylori infection results in storage of iron in the gastric mucosa and an elevated gastric iron concentration.
The study will consist of three aspects: 1. Determining whether oral iron absorption is abnormal for H. pylori-positive IDA patients, and comparison of oral iron absorption for H. pylori positive and negative IDA patients.
This will also include an experimental component in which oral iron absorption will be repeated after H. pylori treatment for H. pylori-infected IDA subjects (and after an equivalent time period for H. pylori negative controls to exclude changes in iron absorption that occur over time).
2. Comparison of H. pylori strain characteristics for IDA patients and non-anemic H. pylori-infected controls.
Characterization of H. pylori strains will include: genetic analysis using a whole genome microarray technique that assesses the presence or absence of H. pylori genes, evaluation of expression of genes related to iron metabolism, and comparison of pattern of gastritis (pan gastritis vs. antrum-predominant).
3. Determination of whether H. pylori stores a significant quantity of iron in the gastric mucosa in vivo.
This will be assessed by measuring the iron concentration in mucosal biopsy specimens and comparing results for H. pylori-infected IDA patients to H. pylori-uninfected IDA controls.
Study Type
Interventional
Enrollment
39
Phase
- Phase 2
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Washington
-
Seattle, Washington, United States, 98108
- VA Puget Sound Health Care System
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- age > 18 years
- iron deficiency anemia (IDA) defined as: Hgb < 14 g/L for men and 12 g/L for women, and a serum ferritin level less than 45 ug/L
Exclusion Criteria:
- Obvious non-GI cause of blood loss
- Chronic renal failure (BUN>60, Creatinine > 4)
- Hemolytic anemia, thalassemia, aplastic anemia
- Known alcoholism or cirrhosis of the liver
- Regular use (>3x weekly) of NSAIDS
- Prior gastric resection
- Celiac disease
- Known GI or hematologic malignancy
- Known inflammatory bowel disease
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Difference in iron absorption (Cmax) for H. pylori infected and uninfected IDA patients.
|
Change following H. pylori treatment in the iron absorption (Cmax) for H. pylori infected IDA patients.
|
Difference in the presence of genes related to iron metabolism for H. pylori-infected IDA patients vs. non-anemic controls.
|
Difference in gastritis pattern between H. pylori-infected IDA patients and non-anemic controls.
|
Secondary Outcome Measures
Outcome Measure |
---|
Difference in gastritis severity between H. pylori-infected IDA patients and non-anemic controls.
|
Difference in gastric iron concentration.
|
Change in Hct and ferritin values following treatment.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: David Kearney, MD, University of Washington
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2002
Study Completion
September 1, 2007
Study Registration Dates
First Submitted
September 13, 2005
First Submitted That Met QC Criteria
September 13, 2005
First Posted (Estimate)
September 20, 2005
Study Record Updates
Last Update Posted (Estimate)
July 30, 2008
Last Update Submitted That Met QC Criteria
July 29, 2008
Last Verified
July 1, 2008
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 02-1807-B 03
- RAB-EMR-420
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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