- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00264940
Diagnosis of Insulin Resistance: 13C-Glucose Breath Test Vs HOMA Index.
December 12, 2005 updated by: Tel-Aviv Sourasky Medical Center
The prevalence of type 2 diabetes is rising in the population for many years.
It is now recognized that a period of glucose intolerance precedes the clinical symptoms appearance.
This is due to a combination of b-cell dysfunction and insulin resistance.
It is estimated that this pre-clinical phase of type 2diabetes may antedate the onset of overt diabetes by 10-12 years.
Furthermore, insulin resistance is considered to be a main component of the metabolic syndrome and associated with significant cardiovascular morbidity and mortality.
Recently, there has been an effort to pinpoint the pre-diabetic phase for early therapeutic intervention in the individual.
These studies, in patients with impaired glucose intolerance, have shown to be beneficial from both lifestyle change and pharmacological intervention.
It is thus hypnotized that intervention in patients with insulin resistance with or without glucose intolerance may prevent the progress of type 2 diabetes and it's complications.
There is difficulty in identifying individuals who are at high risk for type 2 diabetes.
The prevention strategy relies on intervention in a pre-diseased state.
In the case of type 2 diabetes, the early intervention is useful in the phase where there is insulin resistance, but prior to the appearance of glucose intolerance.
The diagnosis of insulin resistance is a challenging one.
The gold standard in diagnosing insulin resistance is the hyperinsulinemic-euglycemic clamp, but this method is not suitable for routine clinical use.
Thus, less invasive methods for evaluation, like homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI), were developed.
There is a correlation between HOMA and QUICKI results and the hyperinsulinemic-euglycemic clamp.
Both HOMA and QUICKI allow insulin resistance diagnosis.
The results from those tests correlate with hyperinsulinemic-euglycemic clamp and allow diagnosing insulin resistance, however, those indexes require serum glucose, insulin measurements and quite complicated calculations.
A new method was suggested, non-invasive, sensitive and simple, for the identification of insulin resistance.
In normal individuals, in the presence of insulin, glucose is taken up by a variety of cells, undergoes glycolysis and enters the tricarboxylic acid cycle or fat synthesis.
In either case, CO2 in produced as a by-product.
This CO2 enters the circulation and is discarded by the lungs.
The new method is based on the assumption that 13C-glucose is ingested as described and its by-product 13CO2 can be measured in the expired air.
In type 2 diabetes and other states of insulin resistance glucose, uptake is impaired and results in blunted 13CO2 production.
This hypothesis was tested by Lewanczuc et al.
The writers compared the [13C]-glucose breath test with hyperinsulinemic-euglycemic clamp, HOMA and QUICKI indexes.
They tested 26 patients at different stages of insulin sensitivity and reported a good correlation of the glucose breath test and the other indexes.
We suggest testing a larger group of patients at high-risk to develop type 2 diabetes and compare the glucose breath test with HOMA index.
Study Overview
Status
Unknown
Study Type
Observational
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Must be able to fast over night
- A blood sample should be drawn
Exclusion Criteria:
- Insulin dependent diabetes
- Pulmunary disorder
- Gastrointestinal disorder
- Endocrine disorder
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Chair: Zamir Halprn, MD
- Principal Investigator: Ilana Goldiner, PhD
- Principal Investigator: Yochanan Peled, PhD
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Registration Dates
First Submitted
December 12, 2005
First Submitted That Met QC Criteria
December 12, 2005
First Posted (Estimate)
December 13, 2005
Study Record Updates
Last Update Posted (Estimate)
December 13, 2005
Last Update Submitted That Met QC Criteria
December 12, 2005
Last Verified
December 1, 2005
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- TASMC-05-ZH-315-CTIL
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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