Prognosis Factors Associated With Convulsive Status Epilepticus in Adults

August 13, 2007 updated by: Versailles Hospital

Prognosis Factors Associated With Convulsive Status Epilepticus in Adults: A Multicenter Cohort Study

The aim of the study is to evaluate, prospectively, prognosis factors associated with convulsive status epilepticus (CSE) in adults hospitalized in intensive care units.

Study Overview

Status

Completed

Conditions

Detailed Description

Status epilepticus is a neurologic and medical emergency associated with high mortality and morbidity rates. According to the operational definition Convulsive Status Epilepticus (CSE) is defined as a single clinical seizure lasting more than 10 min, or two or more repeated seizures over a period of more than 10 minutes without intervening recovery of consciousness.

There are a few to date in literature reporting prognosis factors associated with this condition and, at this time, there are no published data considering an operational definition of CSE.

In a retrospective study considering an operational definition we identified a seizure duration of 15 min associated with poor outcome (not yet published).

The principal goal of this study is to evaluate factors associated with outcome in CSE, in particular seizure duration of more than 15 minutes.

The secondary goals are to evaluate the epidemiology and management at every stage of CSE thus redefined.

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • Abbeville, France, 80100
        • Centre Hospitalier d'Abbeville
      • Annonay, France, 07103
        • Centre Hospitalier d'Annonay
      • Argenteuil, France, 95100
        • Centre Hospitalier Victor Dupouy
      • Aulnay Sous Bois, France, 93
        • Centre Hospitalier Robert Ballanger
      • Cergy Pontoise, France, 95303
        • Centre Hospitalier René Dubos
      • Chartres, France, 28
        • Centre Hospitalier de Chartres
      • Châlons-en-Champagne, France, 51000
        • Centre Hospitalier de Chalons-en-Champagne
      • Clamart, France, 92140
        • Centre Hospitalier Universitaire Antoine Beclere
      • Clermont Ferrand, France, 63000
        • Hôpital Gabriel Montpied
      • Compiegne, France, 60200
        • Centre Hospitalier de Compiegne
      • Creteil, France, 94000
        • Centre Hospitalier Universitaire Henri Mondor
      • Dourdan, France, 91410
        • Centre Hospitalier de Dourdan
      • Dreux, France, 28102
        • Centre Hospitalier de Dreux
      • Grenoble, France, 38
        • Centre hospitalier universitaire de Grenoble
      • Le Chesnay, France, 78150
        • Centre Hospitalier de Versailles
      • Marseille, France, 13385
        • Centre Hospitalier Universitaire La Timone
      • Maubeuge, France, 59607
        • Centre Hospitalier Sambre Avesnois
      • Meaux, France, 77107
        • Centre Hospitalier de Meaux
      • Nancy, France, 54035
        • Centre Hospitalier Universitaire de Nancy
      • Nevers, France, 58000
        • Centre Hospitalier Pierre Bérégovoy
      • Nice, France, 06202
        • Centre Hôspitalier ARCHET
      • Niort, France, 79021
        • Centre Hospitalier Georges Renon
      • Orleans, France, 45067
        • Centre Hospitalier Universitaire d'Orléans
      • PAU, France, 64046
        • Centre Hospitalier Francois Mitterrand
      • Paris, France, 75000
        • Centre Hospitalier Universitaire Cochin
      • Paris, France, 75000
        • Centre Hospitalier Universitaire Lariboisiere
      • Paris, France, 75
        • Centre Hospitalier Bichat Claude Bernard
      • Paris, France, 75
        • Fondation Hôpital Saint Joseph
      • Pessac, France, 33600
        • Clinique Mutualiste de Pessas
      • Poitiers, France
        • Centre Hospitalier Universitaire de Poitiers
      • Roanne, France, 42328
        • Centre Hospitalier de Roanne
      • Rodez, France, 12
        • Centre Hospitalier de Rodez
      • Saint Lo, France, 50000
        • Centre Hospitalier Mémorail France Etats Unis Saint Lo
      • Suresnes, France, 92151
        • Centre Hospitalier Foch

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • More than 18 years old
  • Convulsive status epilepticus according to operational definition as any seizure lasting for 10 minutes or longer, or two or more intermittent seizures lasting for greater than 10 minutes from which the patient did not regain consciousness.
  • Beginning of seizure less than 12 hours before intensive care unit admission
  • Convulsive status epilepticus occurring during intensive care unit stay

Exclusion Criteria:

  • Less than 18 years old
  • Patients that seized up to 9 minutes
  • Beginning of seizure more than 12 hours before intensive care unit admission

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Stephane LEGRIEL, MD, Versailles Hospital
  • Principal Investigator: Bruno MOURVILLIER, MD, Centre Hospitalier Bichat Claude Bernard

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2005

Study Completion

January 1, 2007

Study Registration Dates

First Submitted

April 25, 2006

First Submitted That Met QC Criteria

April 25, 2006

First Posted (Estimate)

April 27, 2006

Study Record Updates

Last Update Posted (Estimate)

August 15, 2007

Last Update Submitted That Met QC Criteria

August 13, 2007

Last Verified

August 1, 2007

More Information

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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