Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer

March 20, 2024 updated by: NSABP Foundation Inc

A Clinical Trial to Determine the Efficacy of Five Years of Letrozole Compared to Placebo in Patients Completing Five Years of Hormonal Therapy Consisting of an Aromatase Inhibitor (AI) or Tamoxifen Followed by an AI in Prolonging Disease-Free Survival in Postmenopausal Women With Hormone Receptor Positive Breast Cancer

RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes. It is not yet known whether letrozole is more effective than a placebo in treating patients with hormone receptor-positive breast cancer.

PURPOSE: This randomized phase III trial is studying letrozole to see how well it works compared with a placebo in treating postmenopausal women who have received hormone therapy for hormone receptor-positive breast cancer.

Study Overview

Status

Active, not recruiting

Conditions

Breast Cancer

Intervention / Treatment

Detailed Description

OBJECTIVES:

Primary

Determine whether or not prolonged adjuvant hormonal therapy comprising letrozole vs placebo will improve disease-free survival of postmenopausal women with estrogen receptor-positive and/or progesterone receptor-positive breast cancer who have completed 5 years of hormonal therapy with 5 years of an aromatase inhibitor (AI) or 5 years of a combination of up to 3 years of tamoxifen citrate followed by an AI.
Compare the disease-free survival of patients treated with these regimens.

Secondary

Compare overall survival of patients treated with these regimens.
Compare breast cancer-free interval of patients treated with these regimens.
Compare distant recurrence in patients treated with these regimens.
Compare the incidence of osteoporotic-related fractures (e.g., Colles', hip, and spine) in these patients treated with these regimens.
Compare the incidence of arterial thrombotic events in patients treated with these regimens.

OUTLINE: This is a double-blind, multicenter, placebo-controlled, randomized study. Patients are stratified according to pathologic nodal status (negative vs positive), adjuvant tamoxifen citrate therapy (yes vs no), and lowest bone mineral density T score for lumbosacral spine, total hip, or femoral neck (> -2.0 vs ≤ -2.0 standard deviation). Patients are randomized to 1 of 2 treatment arms.

Group I: Patients receive oral placebo once daily.
Group II: Patients receive oral letrozole once daily.

In both arms, treatment continues for up to 5 years in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed annually.

PROJECTED ACCRUAL: A total of 3,840 patients will be accrued for this study.

Study Type

Interventional

Enrollment (Actual)

3966

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Canada
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - British Columbia Cancer Agency - Centre for the Southern Interior
  - Surrey, British Columbia, Canada, V3V 1Z2
    - BCCA - Fraser Valley Cancer Centre
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - British Columbia Cancer Agency - Vancouver Cancer Centre
  - Victoria, British Columbia, Canada, V8R 6V5
    - British Columbia Cancer Agency - Vancouver Island Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- Ontario
  - Kingston, Ontario, Canada, K7L 5P9
    - Cancer Centre of Southeastern Ontario At Kingston General Hospital
  - Mississauga, Ontario, Canada, L5M 2N1
    - Carlo Fidani Peel Regional Cancer Centre at Credit Valley Hospital
  - Sudbury, Ontario, Canada, P3E 5J1
    - Northeastern Ontario Regional Cancer Centre
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Cancer Care Program at Thunder Bay Regional Health Sciences
  - Toronto, Ontario, Canada, M5G 1X5
    - Mount Sinai Hospital - Toronto
  - Toronto, Ontario, Canada, M5G 2M9
    - Princess Margaret Hospital
- Quebec
  - Montreal, Quebec, Canada, H3A 1A1
    - Royal Victoria Hospital - Montreal
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital - Montreal
  - Montreal, Quebec, Canada, H2L 4M1
    - Hopital Notre-Dame du CHUM
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM - Hotel Dieu Hospital
  - Montreal, Quebec, Canada, H2X 3J4
    - CHUM - Hopital Saint-Luc
  - Montreal, Quebec, Canada, H3T 1M5
    - St. Mary's Hospital Center
  - Quebec City, Quebec, Canada, G1S 4L8
    - Hopital du Saint-Sacrement - Quebec
Ireland
- - Cork, Ireland
    - Cork University Hospital
  - Cork, Ireland
    - South Infirmary Victoria Hospital
  - Dublin, Ireland, 7
    - Mater Misericordiae University Hospital
  - Dublin, Ireland, 4
    - St. Vincent's University Hospital
  - Dublin, Ireland, 24
    - Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital
  - Dublin, Ireland, 8
    - St. James's Hospital
  - Dublin, Ireland, 0009
    - Beaumont Hospital
  - Galway, Ireland, GY.
    - University College Hospital
  - Limerick, Ireland, 0009
    - Mid-Western Cancer Centre at Mid-Western Regional Hospital
  - Sligo, Ireland, Sligo
    - Sligo General Hospital
  - Waterford, Ireland, 0009
    - Waterford Regional Hospital
United States
- Alabama
  - Anniston, Alabama, United States, 36202
    - Regional Medical Center
  - Mobile, Alabama, United States, 36608
    - Providence Cancer Center at Providence Hospital
- Alaska
  - Anchorage, Alaska, United States, 99508
    - Providence Cancer Center
  - Fairbanks, Alaska, United States, 99701
    - Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
- Arkansas
  - Little Rock, Arkansas, United States, 72205
    - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- California
  - Berkeley, California, United States, 94704
    - Alta Bates Summit Comprehensive Cancer Center
  - Burbank, California, United States, 91505
    - Providence Saint Joseph Medical Center - Burbank
  - Burlingame, California, United States, 94010
    - Peninsula Medical Center
  - Castro Valley, California, United States, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, United States, 94546
    - Eden Medical Center
  - Castro Valley, California, United States, 94546
    - Valley Medical Oncology Consultants - Castro Valley
  - Concord, California, United States, 94524-4110
    - Cancer Care Center at John Muir Health - Concord Campus
  - Duarte, California, United States, 91010-3000
    - City of Hope Comprehensive Cancer Center
  - Fairfield, California, United States, 94533
    - North Bay Cancer Center
  - Fremont, California, United States, 94538
    - Kaiser Permanente - Fremont
  - Fremont, California, United States, 94538
    - Valley Medical Oncology
  - Fresno, California, United States, 93720
    - Cancer Care Associates
  - Fullerton, California, United States, 92835
    - Virginia K. Crosson Cancer Center at St. Jude Medical Center
  - Glendale, California, United States, 91204
    - Glendale Memorial Hospital Comprehensive Cancer Center
  - Greenbrae, California, United States, 94904
    - Marin Cancer Institute at Marin General Hospital
  - Greenbrae, California, United States, 94904
    - Sutter Health - Western Division Cancer Research Group
  - Hayward, California, United States, 94545
    - Kaiser Permanente Medical Center - Hayward
  - La Jolla, California, United States, 92093-0658
    - Rebecca and John Moores UCSD Cancer Center
  - La Jolla, California, United States, 92037
    - Scripps Cancer Center - San Diego
  - Loma Linda, California, United States, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Long Beach, California, United States, 90813
    - Pacific Shores Medical Group - Long Beach
  - Long Beach, California, United States, 90806
    - Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center
  - Los Angeles, California, United States, 90095-1781
    - Jonsson Comprehensive Cancer Center at UCLA
  - Los Angeles, California, United States, 90089-9181
    - USC/Norris Comprehensive Cancer Center and Hospital
  - Martinez, California, United States, 94553-3156
    - Contra Costa Regional Medical Center
  - Mountain View, California, United States, 94040
    - El Camino Hospital Cancer Center
  - Oakland, California, United States, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, United States, 94602
    - Highland General Hospital
  - Oakland, California, United States, 94609
    - Larry G Strieff MD Medical Corporation
  - Oakland, California, United States, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, United States, 94609
    - Bay Area Breast Surgeons, Incorporated
  - Oakland, California, United States, 94609
    - Tom K Lee, Incorporated
  - Oakland, California, United States, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Orange, California, United States, 92868
    - Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
  - Orange, California, United States, 92868
    - St. Joseph Hospital Regional Cancer Center - Orange
  - Palm Springs, California, United States, 92262
    - Desert Regional Medical Center Comprehensive Cancer Center
  - Pleasanton, California, United States, 94588
    - Valley Care Medical Center
  - Pleasanton, California, United States, 94588
    - Valley Medical Oncology Consultants - Pleasanton
  - Pomona, California, United States, 91767
    - Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
  - Rancho Mirage, California, United States, 92270
    - Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
  - Redding, California, United States, 96001
    - North Valley Breast Clinic
  - Redwood City, California, United States, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, United States, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, United States, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Roseville, California, United States, 95661
    - Sutter Cancer Center at Roseville Medical Center
  - Sacramento, California, United States, 95816
    - Sutter Cancer Center
  - Sacramento, California, United States, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, United States, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - Salinas, California, United States, 93901
    - Salinas Valley Memorial Hospital
  - San Diego, California, United States, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Francisco, California, United States, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, United States, 94118
    - California Pacific Medical Center - California Campus
  - San Francisco, California, United States, 94110
    - San Francisco General Hospital Medical Center
  - San Jose, California, United States, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Pablo, California, United States, 94806
    - Doctors Medical Center - San Pablo Campus
  - San Rafael, California, United States, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Clara, California, United States, 95051
    - Kaiser Permanente Medical Center - Santa Clara Kiely Campus
  - Santa Rosa, California, United States, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - South San Francisco, California, United States, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stanford, California, United States, 94305-5824
    - Stanford Cancer Center
  - Stockton, California, United States, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, United States, 94589
    - Sutter Solano Medical Center
  - Vallejo, California, United States, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, United States, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
  - Walnut Creek, California, United States, 94598
    - John Muir/Mt. Diablo Comprehensive Cancer Center
- Colorado
  - Aurora, Colorado, United States, 80045
    - University of Colorado Cancer Center at UC Health Sciences Center
  - Aurora, Colorado, United States, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, United States, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, United States, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Colorado Springs, Colorado, United States, 80909
    - Memorial Hospital Cancer Center - Colorado Springs
  - Denver, Colorado, United States, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, United States, 80220
    - Veterans Affairs Medical Center - Denver
  - Denver, Colorado, United States, 80220
    - Rose Medical Center
  - Denver, Colorado, United States, 80204
    - Denver Health Medical Center
  - Denver, Colorado, United States, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, United States, 80204
    - St. Anthony Central Hospital
  - Denver, Colorado, United States, 80218
    - St. Joseph Hospital
  - Denver, Colorado, United States, 80224-2522
    - CCOP - Colorado Cancer Research Program
  - Edwards, Colorado, United States, 81632
    - Shaw Regional Cancer Center
  - Englewood, Colorado, United States, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, United States, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, United States, 80528
    - Front Range Cancer Specialists
  - Grand Junction, Colorado, United States, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Greeley, Colorado, United States, 80631
    - North Colorado Medical Center
  - Lone Tree, Colorado, United States, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, United States, 80501
    - Hope Cancer Care Center at Longmont United Hospital
  - Loveland, Colorado, United States, 80539
    - McKee Medical Center
  - Pueblo, Colorado, United States, 81004
    - St. Mary - Corwin Regional Medical Center
  - Thornton, Colorado, United States, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, United States, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Bristol, Connecticut, United States, 06011-0977
    - Bristol Hospital
  - Danbury, Connecticut, United States, 06810
    - Praxair Cancer Center at Danbury Hospital
  - Farmington, Connecticut, United States, 06360-2875
    - Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center
  - Hartford, Connecticut, United States, 06105
    - Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center
  - Hartford, Connecticut, United States, 06102-5037
    - Helen and Harry Gray Cancer Center at Hartford Hospital
  - Middletown, Connecticut, United States, 06457
    - Middlesex Hospital Cancer Center
  - Norwalk, Connecticut, United States, 06856
    - Norwalk Hospital
  - Norwich, Connecticut, United States, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, United States, 06904
    - Carl and Dorothy Bennett Cancer Center at Stamford Hospital
  - Torrington, Connecticut, United States, 06790
    - Connecticut Oncology & Hematology - Torrington
  - Waterbury, Connecticut, United States, 06708
    - Harold Leever Regional Cancer Center
- Delaware
  - Lewes, Delaware, United States, 19958
    - Tunnell Cancer Center at Beebe Medical Center
  - Newark, Delaware, United States, 19713
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, United States, 20007
    - Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, United States, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, United States, 20307-5001
    - Walter Reed Army Medical Center
  - Washington, District of Columbia, United States, 20010
    - Washington Cancer Institute at Washington Hospital Center
- Florida
  - Boca Raton, Florida, United States, 33428
    - Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - West
  - Boca Raton, Florida, United States, 33486
    - Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus
  - Clearwater, Florida, United States, 33756
    - Morton Plant Hospital
  - Daytona Beach, Florida, United States, 32114
    - Herbert D. Kerman Regional Oncology Center - Daytona Beach
  - Deerfield Beach, Florida, United States, 33064-3596
    - North Broward Medical Center
  - Fort Lauderdale, Florida, United States, 33308
    - Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Gainesville, Florida, United States, 32610-0232
    - University of Florida Shands Cancer Center
  - Hollywood, Florida, United States, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, United States, 32207
    - Baptist Cancer Institute - Jacksonville
  - Lakeland, Florida, United States, 33805
    - Center for Cancer Care and Research at Watson Clinic, LLP
  - Miami Beach, Florida, United States, 33140
    - CCOP - Mount Sinai Medical Center
  - Orange Park, Florida, United States, 32073
    - Integrated Community Oncology Network - Orange Park
  - Orlando, Florida, United States, 32806
    - M.D. Anderson Cancer Center at Orlando
  - Sarasota, Florida, United States, 34236
    - Florida Cancer Specialists - Sarasota Downtown
  - Weston, Florida, United States, 33331
    - Cleveland Clinic Florida - Weston
- Georgia
  - Albany, Georgia, United States, 31701
    - Phoebe Cancer Center at Phoebe Putney Memorial Hospital
  - Athens, Georgia, United States, 30607
    - Northeast Georgia Cancer Care, LLC - Medical Oncology
  - Atlanta, Georgia, United States, 30322
    - Winship Cancer Institute of Emory University
  - Atlanta, Georgia, United States, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, United States, 30342-1611
    - Northside Hospital Cancer Center
  - Atlanta, Georgia, United States, 30342-1701
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, United States, 30342
    - CCOP - Atlanta Regional
  - Atlanta, Georgia, United States, 30308
    - Emory Crawford Long Hospital
  - Atlanta, Georgia, United States, 30303
    - Georgia Cancer Center for Excellence at Grady Memorial Hospital
  - Augusta, Georgia, United States, 30912
    - MBCCOP - Medical College of Georgia Cancer Center
  - Augusta, Georgia, United States, 30901
    - Augusta Oncology Associates - Walton Way
  - Austell, Georgia, United States, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, United States, 31904
    - John B. Amos Cancer Center
  - Decatur, Georgia, United States, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Gainesville, Georgia, United States, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, United States, 30045
    - Gwinnett Medical Center
  - Marietta, Georgia, United States, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Rome, Georgia, United States, 30165
    - Harbin Clinic Cancer Center - Medical Oncology
  - Savannah, Georgia, United States, 31403-3089
    - Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, United States, 31405
    - Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - 'Aiea, Hawaii, United States, 96701
    - Kapiolani Medical Center at Pali Momi
  - Honolulu, Hawaii, United States, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, United States, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, United States, 96813
    - OnCare Hawaii, Incorporated - Lusitana
  - Honolulu, Hawaii, United States, 96813
    - Queen's Cancer Institute at Queen's Medical Center
  - Honolulu, Hawaii, United States, 96813
    - Straub Clinic and Hospital, Incorporated
  - Honolulu, Hawaii, United States, 96817
    - Hawaii Medical Center - East
  - Honolulu, Hawaii, United States, 96817
    - OnCare Hawaii, Incorporated - Kuakini
  - Wailuku, Hawaii, United States, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, United States, 96793
    - Pacific Cancer Institute - Maui
- Idaho
  - Boise, Idaho, United States, 83712
    - Mountain States Tumor Institute at St. Luke's Regional Medical Center
  - Boise, Idaho, United States, 83706
    - Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
  - Coeur d'Alene, Idaho, United States, 83814
    - Kootenai Cancer Center - Coeur d'Alene
- Illinois
  - Alton, Illinois, United States, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Bloomington, Illinois, United States, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, United States, 61520
    - Graham Hospital
  - Chicago, Illinois, United States, 60612
    - Rush University Medical Center
  - Chicago, Illinois, United States, 60637-1470
    - University of Chicago Cancer Research Center
  - Chicago, Illinois, United States, 60640
    - Louis A. Weiss Memorial Hospital
  - Chicago, Illinois, United States, 60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, United States, 60631
    - Resurrection Medical Center
  - Decatur, Illinois, United States, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Elgin, Illinois, United States, 60120
    - Sherman Hospital
  - Elk Grove Village, Illinois, United States, 60007
    - Alexian Brothers Radiation Oncology
  - Elmhurst, Illinois, United States, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, United States, 61530
    - Eureka Community Hospital
  - Evanston, Illinois, United States, 60201-1781
    - Evanston Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, United States, 61401
    - Galesburg Clinic, PC
  - Havana, Illinois, United States, 62644
    - Mason District Hospital
  - Hinsdale, Illinois, United States, 60521
    - Hinsdale Hematology Oncology Associates
  - Kankakee, Illinois, United States, 60901
    - Provena St. Mary's Regional Cancer Center - Kankakee
  - La Grange, Illinois, United States, 60525
    - La Grange Memorial Hospital
  - Macomb, Illinois, United States, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, United States, 60153
    - Cardinal Bernardin Cancer Center at Loyola University Medical Center
  - Moline, Illinois, United States, 61265
  - Moline, Illinois, United States, 61265
    - Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
  - Monmouth, Illinois, United States, 61462
    - OSF Holy Family Medical Center
  - Mount Vernon, Illinois, United States, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, United States, 60540
    - Edward Hospital Cancer Center
  - Naperville, Illinois, United States, 60540
    - Hematology Oncology Consultants - Naperville
  - Normal, Illinois, United States, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, United States, 61761
    - Community Cancer Center
  - Oak Lawn, Illinois, United States, 60453-2699
    - Advocate Christ Medical Center
  - Ottawa, Illinois, United States, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, United States, 61350
    - Oncology Hematology Associates of Central Illinois, PC - Ottawa
  - Park Ridge, Illinois, United States, 60068-1174
    - Advocate Lutheran General Cancer Care Center
  - Pekin, Illinois, United States, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, United States, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, United States, 61614
    - Proctor Hospital
  - Peoria, Illinois, United States, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, United States, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, United States, 61615
    - Oncology Hematology Associates of Central Illinois, PC - Peoria
  - Peru, Illinois, United States, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, United States, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, United States, 61104-2315
    - Swedish-American Regional Cancer Center
  - Rockford, Illinois, United States, 61108
    - Center for Cancer Care at OSF Saint Anthony Medical Center
  - Spring Valley, Illinois, United States, 61362
    - St. Margaret's Hospital
  - Springfield, Illinois, United States, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Winfield, Illinois, United States, 60190
    - Central Dupage Cancer Center
- Indiana
  - Beech Grove, Indiana, United States, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, United States, 46515
    - Elkhart General Hospital
  - Goshen, Indiana, United States, 46526
    - Center for Cancer Care at Goshen General Hospital
  - Indianapolis, Indiana, United States, 46260
    - St. Vincent Indianapolis Hospital
  - Indianapolis, Indiana, United States, 46219
    - Community Regional Cancer Care at Community Hospital East
  - Indianapolis, Indiana, United States, 46256
    - Community Regional Cancer Care at Community Hospital North
  - Kokomo, Indiana, United States, 46904
    - Howard Community Hospital
  - La Porte, Indiana, United States, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, United States, 47905
    - Horizon Oncology Center
  - Munster, Indiana, United States, 46321
    - Community Hospital
  - Richmond, Indiana, United States, 47374
    - Reid Hospital & Health Care Services
  - South Bend, Indiana, United States, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, United States, 46601
    - CCOP - Northern Indiana CR Consortium
  - South Bend, Indiana, United States, 46617
    - Saint Joseph Regional Medical Center
  - South Bend, Indiana, United States, 46617
    - South Bend Clinic
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic, PC
  - Bettendorf, Iowa, United States, 52722
  - Bettendorf, Iowa, United States, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Cedar Rapids, Iowa, United States, 52402
    - St. Luke's Hospital
  - Cedar Rapids, Iowa, United States, 52403
    - Cedar Rapids Oncology Associates
  - Cedar Rapids, Iowa, United States, 52403
    - Mercy Regional Cancer Center at Mercy Medical Center
  - Cedar Rapids, Iowa, United States, 52402
    - Iowa Blood and Cancer Care
  - Council Bluffs, Iowa, United States, 51503
    - Heartland Oncology and Hematology
  - Davenport, Iowa, United States, 52804
    - Genesis Medical Center - West Campus
  - Davenport, Iowa, United States, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, United States, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, United States, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, United States, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, United States, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, United States, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, United States, 50307
    - Mercy Capitol Hospital
  - Iowa City, Iowa, United States, 52242-1002
    - Holden Comprehensive Cancer Center at University of Iowa
  - Ottumwa, Iowa, United States, 52501
    - McCreery Cancer Center at Ottumwa Regional
  - Sioux City, Iowa, United States, 51101
    - Siouxland Hematology-Oncology Associates, LLP
  - Sioux City, Iowa, United States, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, United States, 51104
    - Mercy Medical Center - Sioux City
  - Waterloo, Iowa, United States, 50702
    - Covenant Cancer Treatment Center
  - Waterloo, Iowa, United States, 50701
    - Cedar Valley Medical Specialists, PC - West Ridgeway Avenue
- Kansas
  - Anthony, Kansas, United States, 67003
    - Hospital District Sixth of Harper County
  - Chanute, Kansas, United States, 66720
    - Cancer Center of Kansas, PA - Chanute
  - Dodge City, Kansas, United States, 67801
    - Cancer Center of Kansas, PA - Dodge City
  - El Dorado, Kansas, United States, 67042
    - Cancer Center of Kansas, PA - El Dorado
  - Fort Scott, Kansas, United States, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, United States, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, United States, 67068
    - Cancer Center of Kansas, PA - Kingman
  - Lawrence, Kansas, United States, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, United States, 67901
    - Southwest Medical Center
  - Newton, Kansas, United States, 67114
    - Cancer Center of Kansas, PA - Newton
  - Parsons, Kansas, United States, 67357
    - Cancer Center of Kansas, PA - Parsons
  - Pittsburg, Kansas, United States, 66762
    - Mount Carmel Regional Cancer Center
  - Pratt, Kansas, United States, 67124
    - Cancer Center of Kansas, PA - Pratt
  - Salina, Kansas, United States, 67042
    - Cancer Center of Kansas, PA - Salina
  - Topeka, Kansas, United States, 66606
    - Cotton-O'Neil Cancer Center
  - Wellington, Kansas, United States, 67152
    - Cancer Center of Kansas, PA - Wellington
  - Wichita, Kansas, United States, 67208
    - Cancer Center of Kansas, PA - Medical Arts Tower
  - Wichita, Kansas, United States, 67214
    - Cancer Center of Kansas, PA - Wichita
  - Wichita, Kansas, United States, 67214
    - CCOP - Wichita
  - Wichita, Kansas, United States, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, United States, 67208
    - Associates in Womens Health, PA - North Review
  - Winfield, Kansas, United States, 67156
    - Cancer Center of Kansas, PA - Winfield
- Kentucky
  - Ashland, Kentucky, United States, 41101-0151
    - Cancer Resource Center at King's Daughters Medical Center
  - Ashland, Kentucky, United States, 41101
    - Cancer Care at Our Lady of Bellefonte Hospital
  - Lexington, Kentucky, United States, 40536-0093
    - Lucille P. Markey Cancer Center at University of Kentucky
  - Lexington, Kentucky, United States, 40503-9985
    - Central Baptist Hospital
  - Louisville, Kentucky, United States, 40207
    - Consultants in Blood Disorders and Cancer
  - Louisville, Kentucky, United States, 40202
    - Louisville Oncology at Norton Cancer Institute - Louisville
  - Louisville, Kentucky, United States, 40215
    - Drs. Carrol, Sheth, Raghavan
- Louisiana
  - Baton Rouge, Louisiana, United States, 70809
    - Mary Bird Perkins Cancer Center - Baton Rouge
  - Baton Rouge, Louisiana, United States, 70809
    - Ochsner Health Center - Bluebonnet
  - Baton Rouge, Louisiana, United States, 70806
    - Pennington Cancer Center at Baton Rouge General
  - Houma, Louisiana, United States, 70360
    - Terrebonne General Medical Center
  - Metairie, Louisiana, United States, 70006
    - Drs Gurtler Brinz and Russo APMC-Metairie Oncologists
  - New Orleans, Louisiana, United States, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, United States, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, United States, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
  - New Orleans, Louisiana, United States, 70112
    - Medical Center of Louisiana - New Orleans
  - Shreveport, Louisiana, United States, 71101
    - Christus Schumpert Cancer Treatment Center
- Maine
  - Bangor, Maine, United States, 04401
    - CancerCare of Maine at Eastern Maine Medical Center
  - Lewiston, Maine, United States, 04240
    - Central Maine Comprehensive Cancer Center at Central Maine Medical Center
  - Portland, Maine, United States, 04101
    - Mercy Hospital
  - York, Maine, United States, 03909
    - York Hospital's Oncology Treatment Center
- Maryland
  - Baltimore, Maryland, United States, 21202
    - Mercy Medical Center
  - Baltimore, Maryland, United States, 21229
    - St. Agnes Hospital Cancer Center
  - Baltimore, Maryland, United States, 21204
    - Greater Baltimore Medical Center Cancer Center
  - Baltimore, Maryland, United States, 21237
    - Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
  - Bethesda, Maryland, United States, 20814
    - Suburban Hospital
  - Easton, Maryland, United States, 21601
    - Shore Regional Cancer Center at Memorial Hospital - Easton
  - Elkton, Maryland, United States, 21921
    - Union Hospital Cancer Program at Union Hospital
  - Frederick, Maryland, United States, 21701
    - Frederick Memorial Hospital Regional Cancer Therapy Center
  - Leonardtown, Maryland, United States, 20650
    - St. Mary's Hospital
  - Salisbury, Maryland, United States, 21801
    - Peninsula Regional Medical Center
- Massachusetts
  - Attleboro, Massachusetts, United States, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, United States, 02118
    - Boston University Cancer Research Center
  - Boston, Massachusetts, United States, 02111
    - Tufts-NEMC Cancer Center
  - Burlington, Massachusetts, United States, 01805
    - Lahey Clinic Medical Center - Burlington
  - Concord, Massachusetts, United States, 01742
    - Commonwealth Hematology-Oncology, PC - Concord
  - Dorchester, Massachusetts, United States, 02124
    - Commonwealth Hematology Oncology PC - Dorchester
  - Fall River, Massachusetts, United States, 02721
    - Hudner Oncology Center at Saint Anne's Hospital - Fall River
  - Fitchburg, Massachusetts, United States, 01420
    - Simonds-Sinon Regional Cancer Center at HealthAlliance Hospital - Burbank Campus
  - Gloucester, Massachusetts, United States, 01930
    - Addison Gilbert Hospital
  - Lawrence, Massachusetts, United States, 01842
    - Commonwealth Hematology-Oncology, PC - Lawrence
  - Leominster, Massachusetts, United States, 01453
    - Commonwealth Hematology Oncology PC - Leominster
  - Methuen, Massachusetts, United States, 01844
    - Caritas Holy Family Hospital
  - Peabody, Massachusetts, United States, 01960
    - NSMC Cancer Center - Peabody
  - Pittsfield, Massachusetts, United States, 01201
    - Berkshire Hematology Oncology, PC
  - Plymouth, Massachusetts, United States, 02360
    - Jordan Hospital Club Cancer Center
  - Quincy, Massachusetts, United States, 02169
    - Commonwealth Hematology-Oncology, PC - Quincy
  - Springfield, Massachusetts, United States, 01199
    - Baystate Regional Cancer Program at D'Amour Center for Cancer Care
  - Stoneham, Massachusetts, United States, 02180
    - Commonwealth Hematology-Oncology, PC - Stoneham
  - Weymouth, Massachusetts, United States, 02190
    - Commonwealth Hematology-Oncology, PC - Weymouth
  - Worcester, Massachusetts, United States, 01655
    - UMASS Memorial Cancer Center - University Campus
  - Worcester, Massachusetts, United States, 01605
    - Commonwealth Hematology-Oncology, PC - Worcester
- Michigan
  - Adrian, Michigan, United States, 49221
    - Hickman Cancer Center at Bixby Medical Center
  - Ann Arbor, Michigan, United States, 48106-0995
    - Saint Joseph Mercy Cancer Center
  - Ann Arbor, Michigan, United States, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, United States, 49017
    - Battle Creek Health System Cancer Care Center
  - Bay City, Michigan, United States, 48708
    - Bay Regional Medical Center
  - Big Rapids, Michigan, United States, 49307
    - Mecosta County Medical Center
  - Dearborn, Michigan, United States, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Detroit, Michigan, United States, 48202
    - Josephine Ford Cancer Center at Henry Ford Hospital
  - Detroit, Michigan, United States, 48201-1379
    - Barbara Ann Karmanos Cancer Institute
  - Escanaba, Michigan, United States, 49431
    - Green Bay Oncology, Limited - Escanaba
  - Flint, Michigan, United States, 48503
    - Hurley Medical Center
  - Flint, Michigan, United States, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, United States, 48532
    - Great Lakes Cancer Institute at McLaren Regional Medical Center
  - Grand Rapids, Michigan, United States, 49503
    - Butterworth Hospital at Spectrum Health
  - Grand Rapids, Michigan, United States, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, United States, 49503
    - Lacks Cancer Center at Saint Mary's Health Care
  - Grosse Pointe Woods, Michigan, United States, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Iron Mountain, Michigan, United States, 49801
    - Dickinson County Healthcare System
  - Jackson, Michigan, United States, 49201
    - Foote Memorial Hospital
  - Kalamazoo, Michigan, United States, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, United States, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, United States, 49007-3731
    - West Michigan Cancer Center
  - Lambertville, Michigan, United States, 48144
    - Haematology-Oncology Associates of Ohio and Michigan, PC
  - Lansing, Michigan, United States, 48912-1811
    - Sparrow Regional Cancer Center
  - Lansing, Michigan, United States, 48910
    - Breslin Cancer Center at Ingham Regional Medical Center
  - Lapeer, Michigan, United States, 48446
    - Lapeer Regional Hospital
  - Livonia, Michigan, United States, 48154
    - St. Mary Mercy Hospital
  - Marquette, Michigan, United States, 49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Midland, Michigan, United States, 48670
    - MidMichigan Medical Center - Midland
  - Monroe, Michigan, United States, 48162
    - Community Cancer Center of Monroe
  - Monroe, Michigan, United States, 48162
    - Mercy Memorial Hospital - Monroe
  - Mount Clemens, Michigan, United States, 48043
    - Clemens Regional Medical Center
  - Muskegon, Michigan, United States, 49443
    - Mercy General Health Partners
  - Pontiac, Michigan, United States, 48341-2985
    - St. Joseph Mercy Oakland
  - Port Huron, Michigan, United States, 48060
    - Mercy Regional Cancer Center at Mercy Hospital
  - Royal Oak, Michigan, United States, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, United States, 48601
    - Seton Cancer Institute at Saint Mary's - Saginaw
  - Saint Joseph, Michigan, United States, 49085
    - Lakeland Regional Cancer Care Center - St. Joseph
  - Southfield, Michigan, United States, 48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City, Michigan, United States, 49684
    - Munson Medical Center
  - Warren, Michigan, United States, 48093
    - St. John Macomb Hospital
  - Wyoming, Michigan, United States, 49519
    - Metro Health Hospital
- Minnesota
  - Bemidji, Minnesota, United States, 56601
    - MeritCare Bemidji
  - Burnsville, Minnesota, United States, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, United States, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Duluth, Minnesota, United States, 55805
    - CCOP - Duluth
  - Duluth, Minnesota, United States, 55805-1983
    - Duluth Clinic Cancer Center - Duluth
  - Duluth, Minnesota, United States, 55805
    - Miller - Dwan Medical Center
  - Duluth, Minnesota, United States, 55805
    - St. Luke's Hospital Cancer Care Center
  - Edina, Minnesota, United States, 55435
    - Fairview Southdale Hospital
  - Fridley, Minnesota, United States, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Hutchinson, Minnesota, United States, 55350
    - Hutchinson Area Health Care
  - Mankato, Minnesota, United States, 56002
    - Immanuel St. Joseph's
  - Maplewood, Minnesota, United States, 55109
    - Minnesota Oncology Hematology, PA - Maplewood
  - Maplewood, Minnesota, United States, 55109
    - HealthEast Cancer Care at St. John's Hospital
  - Minneapolis, Minnesota, United States, 55407
    - Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
  - Minneapolis, Minnesota, United States, 55415
    - Hennepin County Medical Center - Minneapolis
  - Robbinsdale, Minnesota, United States, 55422-2900
    - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
  - Saint Louis Park, Minnesota, United States, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, United States, 55416
    - Park Nicollet Cancer Center
  - Saint Paul, Minnesota, United States, 55102
    - United Hospital
  - Saint Paul, Minnesota, United States, 55101
    - Regions Hospital Cancer Care Center
  - Shakopee, Minnesota, United States, 55379
    - St. Francis Cancer Center at St. Francis Medical Center
  - Waconia, Minnesota, United States, 55387
    - Ridgeview Medical Center
  - Woodbury, Minnesota, United States, 55125
    - Minnesota Oncology Hematology, PA - Woodbury
- Mississippi
  - Hattiesburg, Mississippi, United States, 39401
    - Hattiesburg Clinic, PA at Forrest General
  - Keesler Air Force Base, Mississippi, United States, 39534
    - Keesler Air Force Base Medical Center
  - Pascagoula, Mississippi, United States, 39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, United States, 63703
    - Saint Francis Medical Center
  - Chesterfield, Missouri, United States, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, United States, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Joplin, Missouri, United States, 64804
    - St. John's Regional Medical Center
  - Joplin, Missouri, United States, 64804
    - Freeman Cancer Institute at Freeman Health System
  - Saint Louis, Missouri, United States, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, United States, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, United States, 63110
    - Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
  - Saint Louis, Missouri, United States, 63141
    - Arch Medical Services, Incorporated at Center for Cancer Care and Research
  - Saint Louis, Missouri, United States, 63110
    - Saint Louis University Cancer Center
  - Saint Louis, Missouri, United States, 63109
    - Midwest Hematology Oncology Group, Incorporated
  - Saint Louis, Missouri, United States, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - Saint Louis, Missouri, United States, 63128
    - St. Anthony's Cancer Center
  - Springfield, Missouri, United States, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, United States, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, United States, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, United States, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, United States, 59101
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Billings, Montana, United States, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, United States, 59101
    - St. Vincent Healthcare Cancer Care Services
  - Billings, Montana, United States, 59107-7000
    - Billings Clinic - Downtown
  - Bozeman, Montana, United States, 59715
    - Bozeman Deaconess Cancer Center
  - Butte, Montana, United States, 59701
    - St. James Healthcare Cancer Care
  - Great Falls, Montana, United States, 59405
  - Great Falls, Montana, United States, 59405-5309
    - Big Sky Oncology
  - Great Falls, Montana, United States, 59405
    - Sletten Cancer Institute at Benefis Healthcare
  - Havre, Montana, United States, 59501
    - Northern Montana Hospital
  - Helena, Montana, United States, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, United States, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, United States, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, United States, 59901
    - Kalispell Medical Oncology at KRMC
  - Missoula, Montana, United States, 59801
    - Community Medical Center
  - Missoula, Montana, United States, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, United States, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, United States, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Grand Island, Nebraska, United States, 68803
    - Saint Francis Cancer Treatment Center at Saint Francis Memorial Health Center
  - Kearney, Nebraska, United States, 68848-1990
    - Good Samaritan Cancer Center at Good Samaritan Hospital
  - Lincoln, Nebraska, United States, 68510
    - Cancer Resource Center - Lincoln
  - North Platte, Nebraska, United States, 69103
    - Callahan Cancer Center at Great Plains Regional Medical Center
  - Omaha, Nebraska, United States, 68198-6805
    - UNMC Eppley Cancer Center at the University of Nebraska Medical Center
  - Omaha, Nebraska, United States, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, United States, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, United States, 68124
    - Alegant Health Cancer Center at Bergan Mercy Medical Center
  - Omaha, Nebraska, United States, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, United States, 68114
    - Methodist Estabrook Cancer Center
- Nevada
  - Las Vegas, Nevada, United States, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, United States, 89106
    - CCOP - Nevada Cancer Research Foundation
- New Hampshire
  - Concord, New Hampshire, United States, 03301
    - New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
  - Dover, New Hampshire, United States, 03820
    - Seacoast Cancer Center at Wentworth - Douglass Hospital
  - Exeter, New Hampshire, United States, 03833
    - Center for Cancer Care at Exeter Hospital
  - Hooksett, New Hampshire, United States, 03106
    - New Hampshire Oncology - Hematology, PA - Hooksett
  - Laconia, New Hampshire, United States, 03246
    - Lakes Region General Hospital
  - Portsmouth, New Hampshire, United States, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Brick, New Jersey, United States, 08724
    - Ocean Medical Center at Meridian Health
  - Englewood, New Jersey, United States, 07631
    - Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center
  - Flemington, New Jersey, United States, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Freehold, New Jersey, United States, 07728
    - CentraState Medical Center
  - Hamilton, New Jersey, United States, 08690
    - Cancer Institute of New Jersey at Hamilton
  - Livingston, New Jersey, United States, 07039
    - St. Barnabas Medical Center Cancer Center
  - Marlton, New Jersey, United States, 08053
    - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
  - New Brunswick, New Jersey, United States, 08901
    - Saint Peter's University Hospital
  - New Brunswick, New Jersey, United States, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - Newark, New Jersey, United States, 07112
    - Newark Beth Israel Medical Center
  - Pomona, New Jersey, United States, 08240
    - AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus
  - Princeton, New Jersey, United States, 08540-3298
    - University Medical Center at Princeton
  - Red Bank, New Jersey, United States, 07701
    - Booker Cancer Center at Riverview Medical Center
  - Ridgewood, New Jersey, United States, 07450
    - Valley Hospital - Ridgewood
  - Somerville, New Jersey, United States, 08876
    - Somerset Medical Center
  - Sparta, New Jersey, United States, 07871
    - Frederick R. and Betty M. Smith Cancer Treatment Center
  - Trenton, New Jersey, United States, 08629
    - St. Francis Regional Cancer Center
  - Trenton, New Jersey, United States, 08618
    - Capital Health Regional Cancer Center
  - Vineland, New Jersey, United States, 08360
    - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
  - Voorhees, New Jersey, United States, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
  - Voorhees, New Jersey, United States, 08043
    - Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New Mexico
  - Albuquerque, New Mexico, United States, 87131-5636
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, United States, 87106
    - Hematology Oncology Associates, PC
  - Albuquerque, New Mexico, United States, 87102
    - Lovelace Medical Center - Downtown
  - Albuquerque, New Mexico, United States, 87109
    - New Mexico Cancer Center
- New York
  - Albany, New York, United States, 12206
    - New York Oncology Hematology, PC at Albany Regional Cancer Care
  - Albany, New York, United States, 12208
    - New York Oncology Hematology, PC at Albany Medical Center
  - Amsterdam, New York, United States, 12010
    - Amsterdam Community Cancer Program
  - Bronx, New York, United States, 10461
    - Albert Einstein Cancer Center at Albert Einstein College of Medicine
  - Brooklyn, New York, United States, 11235
    - Coney Island Hospital
  - Buffalo, New York, United States, 14263-0001
    - Roswell Park Cancer Institute
  - East Syracuse, New York, United States, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
  - Glens Falls, New York, United States, 12801
    - Adirondack Cancer Care - Glens Falls
  - Glens Falls, New York, United States, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - Hudson, New York, United States, 12534
    - New York Oncology Hematology, PC - Hudson
  - Lake Success, New York, United States, 11042
    - Monter Cancer Center of the North Shore-LIJ Health System
  - Latham, New York, United States, 12110
    - New York Oncology Hematology, PC - Latham
  - Manhasset, New York, United States, 11030
    - CCOP - North Shore University Hospital
  - Manhasset, New York, United States, 11030
    - Don Monti Comprehensive Cancer Center at North Shore University Hospital
  - Mount Kisco, New York, United States, 10549
    - Northern Westchester Hospital
  - New Hyde Park, New York, United States, 11040
    - Long Island Jewish Medical Center
  - New York, New York, United States, 10032
    - Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
  - Poughkeepsie, New York, United States, 12601
    - Saint Francis Hospital Cancer Center
  - Poughkeepsie, New York, United States, 12601
    - Hudson Valley Oncology Associates
  - Poughkeepsie, New York, United States, 12601-3990
    - Dyson Center for Cancer Care at Vassar Brothers Medical Center
  - Poughkeepsie, New York, United States, 12601
    - Cancer Center of Poughkeepsie
  - Rexford, New York, United States, 12148
    - Riverview Cancer Care Medical Associates, PC
  - Rochester, New York, United States, 14642
    - James P. Wilmot Cancer Center at University of Rochester Medical Center
  - Rochester, New York, United States, 14623
    - Interlakes Oncology/Hematology PC
  - Rochester, New York, United States, 14621
    - Lipson Cancer and Blood Center at Rochester General Hospital
  - Staten Island, New York, United States, 10305
    - Nalitt Cancer Institute at Staten Island University Hospital
  - Stony Brook, New York, United States, 11794-9446
    - Stony Brook University Cancer Center
  - Syracuse, New York, United States, 13210
    - SUNY Upstate Medical University Hospital
  - Troy, New York, United States, 12180
    - Samaritan Hospital at Northeast Health
  - White Plains, New York, United States, 10601
    - Dickstein Cancer Treatment Center at White Plains Hospital Center
- North Carolina
  - Asheboro, North Carolina, United States, 27203-5400
    - Randolph Hospital
  - Asheville, North Carolina, United States, 28801
    - Mission Hospitals - Memorial Campus
  - Asheville, North Carolina, United States, 28801
    - Hope A Women's Cancer Center
  - Burlington, North Carolina, United States, 27216
    - Alamance Cancer Center at Alamance Regional Medical Center
  - Cary, North Carolina, United States, 27511
    - Waverly Hematology Oncology
  - Charlotte, North Carolina, United States, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Charlotte, North Carolina, United States, 28233-3549
    - Presbyterian Cancer Center at Presbyterian Hospital
  - Concord, North Carolina, United States, 28025
    - Batte Cancer Center at Northeast Medical Center
  - Gastonia, North Carolina, United States, 28053
    - CaroMont Cancer Center at Gaston Memorial Hospital
  - Goldsboro, North Carolina, United States, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, United States, 27403-1198
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, United States, 27834
    - Leo W. Jenkins Cancer Center at ECU Medical School
  - Hendersonville, North Carolina, United States, 28791
    - Pardee Memorial Hospital
  - High Point, North Carolina, United States, 27261
    - High Point Regional Hospital
  - Kinston, North Carolina, United States, 28501
    - Kinston Medical Specialists
  - Reidsville, North Carolina, United States, 27320
    - Annie Penn Cancer Center
  - Rutherfordton, North Carolina, United States, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, United States, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, United States, 27889
    - Marion L. Shepard Cancer Center at Beaufort County Hospital
  - Winston-Salem, North Carolina, United States, 27157-1096
    - Wake Forest University Comprehensive Cancer Center
  - Winston-Salem, North Carolina, United States, 27103
    - Forsyth Regional Cancer Center at Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, United States, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, United States, 58501
    - Medcenter One Hospital Cancer Care Center
  - Bismarck, North Dakota, United States, 58501
    - Mid Dakota Clinic, PC
  - Bismarck, North Dakota, United States, 58502
    - St. Alexius Medical Center Cancer Center
  - Fargo, North Dakota, United States, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, United States, 58122
    - MeritCare Broadway
  - Fargo, North Dakota, United States, 58103
    - Dakota Cancer Institute at Dakota Clinic - South University
  - Grand Forks, North Dakota, United States, 58201
    - Altru Cancer Center at Altru Hospital
- Ohio
  - Akron, Ohio, United States, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Akron, Ohio, United States, 44309-2090
    - Summa Center for Cancer Care at Akron City Hospital
  - Barberton, Ohio, United States, 44203
    - Barberton Citizens Hospital
  - Beachwood, Ohio, United States, 44122
    - Cleveland Clinic Beachwood Family Health and Surgery Center
  - Bellefontaine, Ohio, United States, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, United States, 43402
    - Wood County Oncology Center
  - Canton, Ohio, United States, 44710-1799
    - Aultman Cancer Center at Aultman Hospital
  - Canton, Ohio, United States, 44708
    - Mercy Cancer Center at Mercy Medical Center
  - Chillicothe, Ohio, United States, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, United States, 45219
    - Christ Hospital Cancer Center
  - Cincinnati, Ohio, United States, 45242
    - Oncology Hematology Care, Incorporated - Blue Ash
  - Cleveland, Ohio, United States, 44195
    - Cleveland Clinic Taussig Cancer Center
  - Cleveland, Ohio, United States, 44106-5065
    - Case Comprehensive Cancer Center
  - Cleveland, Ohio, United States, 44109
    - MetroHealth Cancer Care Center at MetroHealth Medical Center
  - Cleveland, Ohio, United States, 44111
    - Cleveland Clinic Cancer Center at Fairview Hospital
  - Clyde, Ohio, United States, 43410
    - North Coast Cancer Care - Clyde
  - Columbus, Ohio, United States, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, United States, 43222
    - Mount Carmel Health - West Hospital
  - Columbus, Ohio, United States, 43210-1240
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
  - Columbus, Ohio, United States, 43215
    - CCOP - Columbus
  - Columbus, Ohio, United States, 43215
    - Grant Medical Center Cancer Care
  - Columbus, Ohio, United States, 43228
    - Doctors Hospital at Ohio Health
  - Dayton, Ohio, United States, 45405
    - Grandview Hospital
  - Dayton, Ohio, United States, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, United States, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, United States, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, United States, 45420
    - CCOP - Dayton
  - Delaware, Ohio, United States, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, United States, 44035
    - Hematology Oncology Center
  - Findlay, Ohio, United States, 45840
    - Blanchard Valley Medical Associates
  - Franklin, Ohio, United States, 45005-1066
    - Middletown Regional Hospital
  - Greenville, Ohio, United States, 45331
    - Wayne Hospital
  - Independence, Ohio, United States, 44131
    - Cleveland Clinic Cancer Center
  - Kettering, Ohio, United States, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, United States, 43130
    - Fairfield Medical Center
  - Lima, Ohio, United States, 45804
    - Lima Memorial Hospital
  - Lima, Ohio, United States, 45801
    - St. Rita's Medical Center
  - Mansfield, Ohio, United States, 44903
    - MedCentral - Mansfield Hospital
  - Marietta, Ohio, United States, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Maumee, Ohio, United States, 43537
    - St. Luke's Hospital
  - Maumee, Ohio, United States, 43537-1839
    - Northwest Ohio Oncology Center
  - Mayfield Heights, Ohio, United States, 44124
    - Hillcrest Cancer Center at Hillcrest Hospital
  - Newark, Ohio, United States, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Oregon, Ohio, United States, 43616
    - St. Charles Mercy Hospital
  - Oregon, Ohio, United States, 43616
    - Toledo Clinic - Oregon
  - Salem, Ohio, United States, 44460
    - Cancer Care Center, Incorporated
  - Sandusky, Ohio, United States, 44870
    - North Coast Cancer Care, Incorporated
  - Springfield, Ohio, United States, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, United States, 45504
    - Mercy Medical Center
  - Sylvania, Ohio, United States, 43560
    - Flower Hospital Cancer Center
  - Tiffin, Ohio, United States, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, United States, 43608
    - St. Vincent Mercy Medical Center
  - Toledo, Ohio, United States, 43606
    - Toledo Hospital
  - Toledo, Ohio, United States, 43614
    - Medical University of Ohio Cancer Center
  - Toledo, Ohio, United States, 43617
    - CCOP - Toledo Community Hospital
  - Toledo, Ohio, United States, 43623
    - Toledo Clinic, Incorporated - Main Clinic
  - Toledo, Ohio, United States, 43623
    - St. Anne Mercy Hospital
  - Troy, Ohio, United States, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Wauseon, Ohio, United States, 43567
    - Fulton County Health Center
  - Westerville, Ohio, United States, 43081
    - Mount Carmel St. Ann's Cancer Center
  - Wilmington, Ohio, United States, 45177
    - Clinton Memorial Hospital
  - Wooster, Ohio, United States, 44691
    - Cancer Treatment Center
  - Wooster, Ohio, United States, 44691
    - Cleveland Clinic - Wooster
  - Wright-Patterson Air Force Base, Ohio, United States, 45433-5529
    - United States Air Force Medical Center - Wright-Patterson
  - Xenia, Ohio, United States, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Zanesville, Ohio, United States, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Lawton, Oklahoma, United States, 73505
    - Cleo Craig Cancer Research Clinic
  - Tulsa, Oklahoma, United States, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
- Oregon
  - Bend, Oregon, United States, 97701
    - St. Charles Medical Center - Bend
  - Coos Bay, Oregon, United States, 97420
    - Bay Area Hospital
  - Grants Pass, Oregon, United States, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, United States, 97030
    - Legacy Mount Hood Medical Center
  - Medford, Oregon, United States, 97504
    - Dubs Cancer Center at Rogue Valley Medical Center
  - Medford, Oregon, United States, 97504
    - Providence Cancer Center at PMCC
  - Milwaukie, Oregon, United States, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, United States, 97239-3098
    - Knight Cancer Institute At Oregon Health and Science University
  - Portland, Oregon, United States, 97227
    - Northwest Cancer Specialists at Rose Quarter Cancer Center
  - Portland, Oregon, United States, 97210
    - Legacy Good Samaritan Hospital & Comprehensive Cancer Center
  - Portland, Oregon, United States, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, United States, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, United States, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, United States, 97227
    - Legacy Emanuel Hospital and Health Center and Children's Hospital
  - Portland, Oregon, United States, 97232
    - Kaiser Permanente Health Care - Portland
  - Salem, Oregon, United States, 97309-5014
    - Salem Hospital Regional Cancer Care Services
  - Tualatin, Oregon, United States, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, United States, 18102
    - Sacred Heart Hospital
  - Allentown, Pennsylvania, United States, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - Bethlehem, Pennsylvania, United States, 18015
    - St. Luke's Cancer Network at St. Luke's Hospital
  - Bryn Mawr, Pennsylvania, United States, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, United States, 17822-0001
    - Geisinger Cancer Institute at Geisinger Health
  - Darby, Pennsylvania, United States, 19023
    - Mercy Fitzgerald Hospital
  - DuBois, Pennsylvania, United States, 15801
    - Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
  - East Stroudsburg, Pennsylvania, United States, 18301
    - Dale and Frances Hughes Cancer Center at Pocono Medical Center
  - Hazleton, Pennsylvania, United States, 18201
    - Geisinger Hazleton Cancer Center
  - Hershey, Pennsylvania, United States, 17033-0850
    - Penn State Cancer Institute at Milton S. Hershey Medical Center
  - Lancaster, Pennsylvania, United States, 17604
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, United States, 19047
    - St. Mary Regional Cancer Center
  - Meadowbrook, Pennsylvania, United States, 19046
    - Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital
  - Media, Pennsylvania, United States, 19063
    - Riddle Memorial Hospital Cancer Center
  - Paoli, Pennsylvania, United States, 19301-1792
    - Cancer Center of Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, United States, 19104-4283
    - Abramson Cancer Center of the University of Pennsylvania
  - Philadelphia, Pennsylvania, United States, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, United States, 19107-5541
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Philadelphia, Pennsylvania, United States, 19114
    - Frankford Hospital Cancer Center - Torresdale Campus
  - Phoenixville, Pennsylvania, United States, 19460
    - Cancer Center at Phoenixville Hospital
  - Pittsburgh, Pennsylvania, United States, 15232
    - UPMC Cancer Centers
  - Pittsburgh, Pennsylvania, United States, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh, Pennsylvania, United States, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Reading, Pennsylvania, United States, 19605
    - St. Joseph Medical Center
  - Reading, Pennsylvania, United States, 19612-6052
    - McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
  - Scranton, Pennsylvania, United States, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, United States, 18510
    - Hematology and Oncology Associates of Northeastern Pennsylvania
  - State College, Pennsylvania, United States, 16801
    - Geisinger Medical Group - Scenery Park
  - Upland, Pennsylvania, United States, 19013
    - Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
  - West Chester, Pennsylvania, United States, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, United States, 19390-9499
    - Jennersville Regional Hospital
  - Wilkes-Barre, Pennsylvania, United States, 18711
    - Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
  - Wynnewood, Pennsylvania, United States, 19096
    - Lankenau Cancer Center at Lankenau Hospital
  - Wynnewood, Pennsylvania, United States, 19096
    - CCOP - Main Line Health
  - York, Pennsylvania, United States, 17405
    - York Cancer Center at Apple Hill Medical Center
- Rhode Island
  - Providence, Rhode Island, United States, 02906
    - Miriam Hospital
  - Providence, Rhode Island, United States, 02905
    - Women and Infants Hospital of Rhode Island
  - Providence, Rhode Island, United States, 02903
    - Rhode Island Hospital Comprehensive Cancer Center
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - AnMed Cancer Center
  - Charleston, South Carolina, United States, 29425
    - Hollings Cancer Center at Medical University of South Carolina
  - Charleston, South Carolina, United States, 29401
    - Roper St. Francis Cancer Center at Roper Hospital
  - Florence, South Carolina, United States, 29501
    - McLeod Regional Medical Center
  - Georgetown, South Carolina, United States, 29440
    - Georgetown Memorial Hospital
  - Greenville, South Carolina, United States, 29615
    - CCOP - Greenville
  - Lancaster, South Carolina, United States, 29720
    - Carolina Blood and Cancer Care Associates, PA
  - Rock Hill, South Carolina, United States, 29732
    - Carolina Blood and Cancer Care
  - Spartanburg, South Carolina, United States, 29303
    - CCOP - Upstate Carolina
  - Spartanburg, South Carolina, United States, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
  - West Columbia, South Carolina, United States, 29169
    - Lexington Medical Center
- South Dakota
  - Rapid City, South Dakota, United States, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, United States, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, United States, 57105
    - Medical X-Ray Center, PC
  - Sioux Falls, South Dakota, United States, 57117-5039
    - Sanford Cancer Center at Sanford USD Medical Center
- Tennessee
  - Kingsport, Tennessee, United States, 37662
    - Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
  - Knoxville, Tennessee, United States, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, United States, 37920-6999
    - U.T. Medical Center Cancer Institute
  - Memphis, Tennessee, United States, 38104
    - University of Tennessee Cancer Institute - Memphis
- Texas
  - Austin, Texas, United States, 78705
    - Southwest Regional Cancer Center - Central
  - Austin, Texas, United States, 78731
    - Texas Oncology, PA at Texas Oncology Cancer Center - Central
  - Austin, Texas, United States, 78759
    - Texas Oncology, PA - Austin Northwest
  - Austin, Texas, United States, 78759
    - Texas Oncology, PA - Austin North
  - Bryan, Texas, United States, 77802
    - St. Joseph Regional Cancer Center
  - Cedar Park, Texas, United States, 78613
    - Texas Oncology, PA - Cedar Park
  - Dallas, Texas, United States, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, United States, 75231
    - Presbyterian Hospital of Dallas
  - Houston, Texas, United States, 77030-4009
    - M. D. Anderson Cancer Center at University of Texas
  - Houston, Texas, United States, 77030
    - Baylor University Medical Center - Houston
  - Lubbock, Texas, United States, 79410-1894
    - Joe Arrington Cancer Research and Treatment Center
  - Lubbock, Texas, United States, 79415-3364
    - UMC Southwest Cancer and Research Center
  - Round Rock, Texas, United States, 78681
    - Texas Oncology, PA at Texas Cancer Center Round Rock
  - Round Rock, Texas, United States, 78665
    - Texas Oncology, PA - Seton Williamson
  - San Antonio, Texas, United States, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - San Marcos, Texas, United States, 78666
    - Texas Oncology, PA - San Marcos
- Utah
  - American Fork, Utah, United States, 84003
    - American Fork Hospital
  - Cedar City, Utah, United States, 84720
    - Sandra L. Maxwell Cancer Center
  - Logan, Utah, United States, 84321
    - Logan Regional Hospital
  - Murray, Utah, United States, 84157
    - Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
  - Ogden, Utah, United States, 84403
    - Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
  - Provo, Utah, United States, 84604
    - Utah Valley Regional Medical Center - Provo
  - Saint George, Utah, United States, 84770
    - Dixie Regional Medical Center - East Campus
  - Salt Lake City, Utah, United States, 84103
    - LDS Hospital
  - Salt Lake City, Utah, United States, 84106
    - Utah Cancer Specialists at UCS Cancer Center
- Vermont
  - Berlin, Vermont, United States, 05602
    - Mountainview Medical
  - Burlington, Vermont, United States, 05401
    - Fletcher Allen Health Care - University Health Center Campus
- Virginia
  - Fredericksburg, Virginia, United States, 22401
    - Fredericksburg Oncology, Incorporated
  - Lynchburg, Virginia, United States, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Norton, Virginia, United States, 24273
    - Southwest Virginia Regional Cancer Center at Wellmonth Health
  - Richmond, Virginia, United States, 23298-0037
    - Virginia Commonwealth University Massey Cancer Center
  - Roanoke, Virginia, United States, 24014
    - Carilion Cancer Center of Western Virginia
- Washington
  - Auburn, Washington, United States, 98002
    - Auburn Regional Center for Cancer Care
  - Bellevue, Washington, United States, 98004
    - Overlake Cancer Center at Overlake Hospital Medical Center
  - Bellingham, Washington, United States, 98225
    - St. Joseph Cancer Center
  - Bremerton, Washington, United States, 98310
    - Olympic Hematology and Oncology
  - Centralia, Washington, United States, 98531-9027
    - Providence Centralia Hospital
  - Federal Way, Washington, United States, 98003
    - St. Francis Hospital
  - Kirkland, Washington, United States, 98033
    - Cascade Cancer Center at Evergreen Hospital Medical Center
  - Olympia, Washington, United States, 98506-5166
    - Providence St. Peter Hospital Regional Cancer Center
  - Puyallup, Washington, United States, 98372
    - Good Samaritan Cancer Center
  - Renton, Washington, United States, 98055
    - Valley Medical Center
  - Seattle, Washington, United States, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, United States, 98104
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, United States, 98112
    - Group Health Central Hospital
  - Seattle, Washington, United States, 98122-4307
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Spokane, Washington, United States, 99204-2967
    - Rockwood Clinic Cancer Treatment Center
  - Spokane, Washington, United States, 99218
    - Cancer Care Northwest - North
  - Tacoma, Washington, United States, 98405-3004
    - Franciscan Cancer Center at St. Joseph Medical Center
  - Tacoma, Washington, United States, 98405
    - Allenmore Hospital
  - Tacoma, Washington, United States, 98405
    - CCOP - Northwest
  - Tacoma, Washington, United States, 98405
    - MultiCare Regional Cancer Center at Tacoma General Hospital
  - Tacoma, Washington, United States, 98499
    - St. Clare Hospital
  - Tacoma, Washington, United States, 98431
    - Madigan Army Medical Center - Tacoma
  - Vancouver, Washington, United States, 98668
    - Southwest Washington Medical Center Cancer Center
  - Walla Walla, Washington, United States, 99362
    - St. Mary Regional Cancer Center at St. Mary Medical Center
  - Wenatchee, Washington, United States, 98801-2028
    - Wenatchee Valley Medical Center
  - Yakima, Washington, United States, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yakima, Washington, United States, 98902
    - Washington Hematology-Oncology Specialists
- West Virginia
  - Charleston, West Virginia, United States, 25304
    - West Virginia University Health Sciences Center - Charleston
  - Clarksburg, West Virginia, United States, 26301
    - United Hospital Center
  - Huntington, West Virginia, United States, 25701
    - Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
  - Huntington, West Virginia, United States, 25702
    - St. Mary's Regional Cancer Center at St. Mary's Medical Center
  - Morgantown, West Virginia, United States, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
  - Parkersburg, West Virginia, United States, 26102
    - Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
  - Wheeling, West Virginia, United States, 26003
    - Schiffler Cancer Center at Wheeling Hospital
- Wisconsin
  - Chippewa Falls, Wisconsin, United States, 54729
    - Marshfield Clinic - Chippewa Center
  - Eau Claire, Wisconsin, United States, 54701
    - Marshfield Clinic Cancer Care at Regional Cancer Center
  - Eau Claire, Wisconsin, United States, 54703-1510
    - Midelfort Clinic - Luther
  - Eau Claire, Wisconsin, United States, 54702
    - Luther Midlelfort Hospital
  - Elkhorn, Wisconsin, United States, 53121
    - Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
  - Glendale, Wisconsin, United States, 53212-1038
    - Oncology Alliance, SC - Milwaukee - East
  - Green Bay, Wisconsin, United States, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, United States, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, United States, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, United States, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Green Bay, Wisconsin, United States, 54311
    - Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
  - Janesville, Wisconsin, United States, 53547
    - Mercy Regional Cancer Center
  - La Crosse, Wisconsin, United States, 54601
    - Gundersen Lutheran Center for Cancer and Blood
  - Madison, Wisconsin, United States, 53717
    - Dean Medical Center - Madison
  - Manitowoc, Wisconsin, United States, 54221-1450
    - Holy Family Memorial Medical Center Cancer Care Center
  - Marinette, Wisconsin, United States, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marinette, Wisconsin, United States, 54143
    - Vince Lombardi Cancer Clinic - Marinette
  - Marshfield, Wisconsin, United States, 54449
    - Saint Joseph's Hospital
  - Marshfield, Wisconsin, United States, 54449
    - Marshfield Clinic - Marshfield Center
  - Mequon, Wisconsin, United States, 53097
    - Columbia Saint Mary's Hospital - Ozaukee
  - Milwaukee, Wisconsin, United States, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, United States, 53201-0342
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, United States, 53215
    - Medical Consultants, Limited
  - Milwaukee, Wisconsin, United States, 53211
    - Columbia-Saint Mary's Cancer Care Center
  - Minocqua, Wisconsin, United States, 54548
    - Marshfield Clinic - Lakeland Center
  - Oconomowoc, Wisconsin, United States, 53066
    - Regional Cancer Center at Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, United States, 54154
    - Green Bay Oncology, Limited - Oconto Falls
  - Oshkosh, Wisconsin, United States, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, United States, 53405
    - All Saints Cancer Center at Wheaton Franciscan Healthcare
  - Rhinelander, Wisconsin, United States, 54501
    - Ministry Medical Group at Saint Mary's Hospital
  - Rice Lake, Wisconsin, United States, 54868
    - Marshfield Clinic - Indianhead Center
  - Sheboygan, Wisconsin, United States, 53081
    - Vince Lombardi Cancer Clinic - Sheboygan
  - Stevens Point, Wisconsin, United States, 54481
    - Saint Michael's Hospital Cancer Center
  - Sturgeon Bay, Wisconsin, United States, 54235
    - Green Bay Oncology, Limited - Sturgeon Bay
  - Two Rivers, Wisconsin, United States, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Waukesha, Wisconsin, United States, 53188
    - Waukesha Memorial Hospital Regional Cancer Center
  - Wausau, Wisconsin, United States, 54401
    - Marshfield Clinic - Wausau Center
  - Wausau, Wisconsin, United States, 54401
    - University of Wisconcin Cancer Center at Aspirus Wausau Hospital
  - West Allis, Wisconsin, United States, 53227
    - Aurora Women's Pavilion of West Allis Memorial Hospital
  - Weston, Wisconsin, United States, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, United States, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, United States, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, United States, 54494
    - Riverview UW Cancer Center at Riverview Hospital
- Wyoming
  - Sheridan, Wyoming, United States, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 120 years (Adult, Older Adult)

Accepts Healthy Volunteers

Description

Eligibility Criteria

Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 (0 = fully active, able to carry on all pre-disease performance without restriction; 1 = restricted in physically strenuous activity but ambulatory).
Patients must be postmenopausal at the time of randomization. (Note: Premenopausal or perimenopausal women requiring therapy with luteinizing hormone-releasing hormone [LHRH] analogs to suppress ovarian function are not eligible.) For study purposes, postmenopausal is defined as: age 56 or older with no spontaneous menses for at least 12 months prior to study entry, or age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) AND with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standards, or a prior documented bilateral oophorectomy.
The patient must have remained disease-free from the time of initial breast cancer diagnosis until the time of randomization.
The patient must have had histologically-confirmed invasive carcinoma of the breast by diagnostic core needle biopsy or by final pathologic evaluation of the surgical specimen.
Patients who received neoadjuvant chemotherapy must have been clinical Stage I, II, or IIIA. For patients who received adjuvant chemotherapy, the primary tumor must have been T1-3 on pathologic evaluation and ipsilateral nodes must have been pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b.
The primary tumor must have been estrogen receptor (ER)-positive and/or progesterone receptor (PgR)-positive. (Patients who had a tumor that was considered to be borderline for hormone receptor positivity and who were treated with tamoxifen and/or an aromatases inhibitor (AI) are eligible for this study.)
Patients must have undergone either a lumpectomy with axillary nodal staging followed by breast radiotherapy or a total mastectomy with axillary nodal staging. (Acceptable axillary nodal staging procedures include sentinel node biopsy alone, if sentinel nodes were negative on hematoxylin and eosin (H&E) staining.)
The duration of the patient's hormonal therapy following breast cancer diagnosis must have been 57-63 months from the first dose regardless of the number of missed doses. Hormonal therapy must have consisted of an AI or a combination of up to 3 years of tamoxifen followed by an AI. Tamoxifen may not have been given during years 4 and 5 of the 5 years of adjuvant hormonal therapy. (Note: Patients must discontinue their adjuvant AI therapy at the time of randomization.)
Optional Letrozole Registration Program for patients who have not yet completed 5 years of hormonal therapy. (Note: As of September 5, 2008, the optional NSABP B-42 Registration Program closed to patient enrollment. Accrual and data collection for the NSABP B-42 randomized treatment trial continues as planned.) In order to have a predominantly letrozole-treated population for B-42 study entry, patients who have had a minimum of 2 years of hormonal therapy and who are currently on tamoxifen (for up to 3 years) or an AI may be offered letrozole at no cost until they complete 5 total years of initial adjuvant hormonal therapy.
B-42 randomization must be within 6 months following completion of 5 years (57-63 months) of initial adjuvant hormonal therapy.
At the time of randomization, the patient must have had the following: history and physical exam within 3 months demonstrating no findings suggestive of recurrent breast cancer; bilateral mammogram within 1 year (unilateral if patient had a mastectomy); mammogram not required if patient had a prophylactic contralateral mastectomy; bone mineral density (BMD) testing within 1 year; and fasting lipid profile (total cholesterol, LDL-C, HDL-C, and triglycerides) with a total cholesterol value less than or equal to grade 1 (according to CTCAE v3.0), with or without cholesterol-lowering therapy.
- within 1 year if the patient has a history of hypercholesterolemia controlled with cholesterol-lowering therapy and/or therapeutic lifestyle changes or if the patient has a history of one or more of the following risk factors for future cardiovascular events: diabetes, hypertension, obesity, tobacco use, hypertriglyceridemia, documented coronary artery disease, or family history of premature coronary heart disease.
- within 2 years for all other patients.

Ineligibility Criteria

Patients with one or more of the following conditions will be ineligible for this study:
History of non-traumatic osteoporotic fracture of wrist, hip, or spine.
Diagnosis of bilateral breast cancer including ductal carcinoma in situ (DCIS)[(synchronous or metachronous].
Other malignancies unless the patient is considered to be disease-free for 5 or more years prior to randomization, and is deemed by their physician to be at low risk for recurrence. Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: carcinoma in situ of the cervix, colon carcinoma in situ, melanoma in situ, and basal cell and squamous cell carcinoma of the skin.
Sex hormonal therapy, e.g., estrogen- or progesterone-replacement therapy or oral contraceptives. These patients are eligible only if this therapy is discontinued prior to randomization.
Therapy with any hormonal agent such as raloxifene for management of osteoporosis. Patients are eligible only if these medications are discontinued prior to study entry.
Administration of any investigational agent within 30 days before study entry.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Group 2 Letrozole Patients receive oral letrozole once daily for up to 5 years.	Drug: Letrozole Letrozole 2.5 mg taken orally once daily for 5 years
Placebo Comparator: Group 1 Placebo Patients receive oral placebo once daily for up to 5 years.	Other: Placebo Placebo tablet taken orally once daily for 5 years

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Disease-free Survival Time Frame: 7 years.	Percentage of patients free from DFS events. DFS events include local, regional, or distant recurrence, second primary cancer or death from any cause prior to recurrence or second primary cancer.	7 years.

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall Survival Time Frame: 7 years	Percentage of patients alive	7 years
Breast Cancer-free Interval Time Frame: 7 years	Cumulative incidence of breast-cancer-free interval events. BCFI events include local-regional recurrence, distant recurrence or contralateral breast cancer as a first event.	7 years
Distant Recurrence Time Frame: 7 years	Cumulative incidence of distant recurrences.	7 years
Osteoporotic-related Fractures Time Frame: 7 years	Cumulative incidence of osteoporotic-related fractures defined as Colles', hip or spinal fractures	7 years
Arterial Thrombotic Events Time Frame: 7 years	Cumulative incidence of arterial thrombotic events, as defined by CTCAE version 4.0 (grade ≥1 stroke or transient ischaemic attack; grade ≥2 acute coronary syndrome or cerebrovascular ischaemia; grade ≥3 myocardial infarction, peripheral ischaemia, or visceral arterial ischaemia; and grade ≥4 selected thromboembolic events [cerebrovascular event, arterial insufficiency]).	7 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

NSABP Foundation Inc

Collaborators

National Cancer Institute (NCI)

Novartis

Investigators

Principal Investigator: Norman Wolmark, MD, NSABP Foundation Inc

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2006

Primary Completion (Actual)

August 25, 2016

Study Completion (Estimated)

April 1, 2025

Study Registration Dates

First Submitted

September 26, 2006

First Submitted That Met QC Criteria

September 26, 2006

First Posted (Estimated)

September 28, 2006

Study Record Updates

Last Update Posted (Actual)

March 22, 2024

Last Update Submitted That Met QC Criteria

March 20, 2024

Last Verified

March 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

NSABP B-42
U10CA012027 (U.S. NIH Grant/Contract)

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Clinical Trials on Breast Cancer

Northwestern University
Eisai Inc.

Unknown

Carboplatin and Eribulin Mesylate in Triple Negative Breast Cancer Patients

Male Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative...

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); Rutgers Cancer Institute of New Jersey

Active, not recruiting

Pegylated Liposomal Doxorubicin Hydrochloride and Carboplatin Followed by Surgery and Paclitaxel in Treating Patients With Triple Negative Stage II-III Breast Cancer

Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast Cancer

United States
University of Southern California
National Cancer Institute (NCI)

Terminated

Endoscopic Breast Surgery in Treating Patients With Breast Cancer

Male Breast Cancer | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer

United States
University of Southern California
National Cancer Institute (NCI)

Withdrawn

Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery

Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer
University of Washington

Terminated

Occupational Therapist-Led Work Intervention in Facilitating Work Maintenance or Re-entry to the Workforce in Patients With Stage I to III Breast Cancer Undergoing Chemotherapy

Breast Cancer | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III | Breast Cancer Stage IIB | Breast Cancer Stage IIA | Breast Cancer Stage IIIA | Breast Cancer Stage IIIB | Breast Cancer Stage IIIc

United States
Celgene

Completed

Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer) (tnAcity)

Breast Cancer | Metastatic Breast Cancer | Stage IV Breast Cancer | Triple-negative Breast Cancer | Recurrent Breast Cancer | Breast Tumor | Cancer of the Breast | Triple-negative Metastatic Breast Cancer | Estrogen Receptor- Negative Breast Cancer | HER2- Negative Breast Cancer | Progesterone Receptor- Negative...

United States, United Kingdom, Italy, Germany, Spain, Canada, Portugal, Australia, Austria, Greece, Brazil, France
University of Southern California
National Cancer Institute (NCI)

Terminated

PET/CT in Evaluating Response to Chemotherapy in Patients With Breast Cancer

HER2-positive Breast Cancer | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By Surgery

HER2-positive Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Estrogen Receptor-negative Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-negative Breast Cancer | Progesterone Receptor-positive Breast...

United States
University of California, Irvine
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Carboplatin+Nab-paclitaxel, Plus Trastuzumab (HER2+) or Bevacizumab (HER2-) in the Neoadjuvant Setting

Breast Cancer | HER2-positive Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | HER2-negative Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Doxorubicin Hydrochloride, Cyclophosphamide, and Filgrastim Followed By Paclitaxel Albumin-Stabilized Nanoparticle Formulation With or Without Trastuzumab in Treating Patients With Breast Cancer Previously Treated With Surgery

HER2-positive Breast Cancer | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-positive Breast Cancer

United States

Clinical Trials on Letrozole

Helsinki University Central Hospital
Foundation for Paediatric Research, Finland

Completed

Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment (CDGP)

Constitutional Delay of Growth and Puberty

Finland
Rovi Pharmaceuticals Laboratories

Recruiting

Evaluation of the Pharmacokinetics, Safety, and Tolerability of IM Letrozole LEBE in Healthy Post-menopausal Women (LEILA-1)

Healthy

Czechia
Institut du Cancer de Montpellier - Val d'Aurelle
Novartis

Completed

Concomitant and Sequential Radiohormonotherapy in Adjuvant Breast Cancer

Breast Cancer

France
University of Alabama at Birmingham
Genentech, Inc.; Breast Cancer Research Foundation

Completed

Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer

Breast Cancer | Breast Neoplasm | Cancer of the Breast

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Pfizer

Completed

Study Evaluating Temsirolimus (CCI-779) In Breast Neoplasms

Breast Neoplasms
Fudan University

Recruiting

Letrozole as Maintenance Therapy for Post-surgical Endometrial Cancer Patients With NSMP

Endometrial Cancer

China
IVI Madrid

Active, not recruiting

Effects of Letrozole During the Luteal Phase After Controlled Ovarian Stimulation in Oocyte Donors. (LETRODON)

Luteinised Follicular Cyst

Spain
Assiut University

Recruiting

Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome

Infertility, Female

Egypt
Cairo University
Ahmed Elgazzar Hospital

Completed

Extended High Dose Letrozole Regimen Versus Short Low Dose Letrozole Regimen as an Adjuvant to GnRH Antagonist Protocol in the Management of Poor Responders Undergoing IVF-ET

Infertility

Egypt
Novartis Pharmaceuticals

Completed

Everolimus and Letrozole as Preoperative Therapy of Primary Breast Cancer in Post-menopausal Women

Breast Neoplasm

United States, Germany, Spain, United Kingdom, France, Austria, Russian Federation, Italy, Canada, Belgium

Letrozole in Treating Postmenopausal Women Who Have Received Hormone Therapy for Hormone Receptor-Positive Breast Cancer

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Clinical Trials on Breast Cancer

Clinical Trials on Letrozole

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