Computer Assisted Early Detection of Liver Metastases From fMRI Maps

February 13, 2007 updated by: Hadassah Medical Organization
The purpose of this protocol is to develop a detailed MRI technique and haemodynamic maps enabling early detection of colorectal metastases in the liver.

Study Overview

Status

Unknown

Conditions

Detailed Description

In this research, we propose to develop methods and protocols for imaging-based, non-invasive early detection and diagnosis of colon cancer metastases. Colon cancer is the third most common cancer worldwide. While it is amenable to surgery if detected early, advanced carcinomas are usually lethal, with liver metastases being the most common cause of death. Early and accurate detection of these lesions is recognized as having the potential of improving survival rates and reducing treatment morbidity. Current diagnostic imaging offers improved discrimination and sensitivity that can be used for earlier detection of smaller lesions conducive to curative therapy.

In previous research, we demonstrated the feasibility of fMRI based on hypercapnia and hyperoxia for monitoring changes in liver perfusion and hemodynamics without contrast agent administration. The isolation and analysis of areas with significant hemodynamical changes in images acquired at early phase of tumor development has proven to be a difficult, time consuming, and potentially unreliable task. Our goal is thus two-fold: 1. use image processing and machine learning tools on a training set of hemodynamical maps obtained from well validated tumors to automate the process and improve its discrimination and sensitivity characteristics, and; 2. implement our method in patients with colorectal liver metastases. The method can help general radiologists with no image processing training to highlight undetectable tumors from background noise and increase diagnosis specificity and sensitivity.

Study Type

Observational

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Israel
      • Jerusalem, Israel, 91120
        • Hadassah Medical Organization
        • Principal Investigator:
          • Ayala Hubert, MD
        • Principal Investigator:
          • Rinat Abramovitch, PhD
      • Jerusalem, Israel, 96000
        • Hebrew University
        • Principal Investigator:
          • Leo Joskowicz, PhD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Control group of healthy volunteers
  • Study group: Patients with colon cancer stage III or IV with high suspicion of liver metastases: raising CEA, suspected lesion in the liver by CT or PET.

Exclusion Criteria:

  • Contraindication to perform MRI.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hadassah Medical Organization

Investigators

  • Principal Investigator: Abramovitch Rinat, PhD, Hadassah Medical Organization
  • Principal Investigator: Joskowicz Leo, PhD, Hebrew University, Jerusalem

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted

February 13, 2007

First Submitted That Met QC Criteria

February 13, 2007

First Posted (Estimate)

February 14, 2007

Study Record Updates

Last Update Posted (Estimate)

February 14, 2007

Last Update Submitted That Met QC Criteria

February 13, 2007

Last Verified

February 1, 2007

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • colmri-HMO-CTIL

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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