Non-acute Coronary occlusIon Treated By Everolimus ELuting Stent (CIBELES)

June 18, 2012 updated by: Raul Moreno

Randomized Comparison Between Sirolimus-eluting and Everolimus-eluting Coronary Stents in Chronic Coronary Occlusions

Chronic total coronary occlusions (CTO) have an especially high risk of angiographic restenosis, and need for new revascularization procedures. Drug-eluting coronary stents (DES) have demonstrated to significantly reduce the risk of restenosis and new revascularization procedures in comparison with bare-metal stents.

Most data on the efficacy of DES come from the sirolimus-eluting coronary stent Cypher (Cordis corp.), and paclitaxel-eluting coronary stent Taxus (Boston Sci.), and the Cypher stent is the only DES that has been randomly tested in CTO. Among second-generation DES, everolimus-eluting stent (EES) has shown excellent angiographic and clinical results, but this DES has not been studied in unfavourable scenario (such as CTO).

The aim of the CIBELES trial is to demonstrate the hypothesis that EES are equally effective in comparison with sirolimus-eluting stents in the treatment of CTO, in terms of angiographic efficacy considered as in-stent late lumen loss.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

207

Phase

  • Phase 3

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Patients ≥ 18 year-old.
  • A total occlusion (TIMI 0-1) with an estimated time of occlusion > 2 weeks.
  • Symptomatic or silent ischaemia, or viable myocardium.
  • The occlusion is suitable for percutaneous coronary intervention.
  • The guidewire has crossed the occlusion, and the occlusion has been dilated with balloon or other device.

Exclusion Criteria:

  • Acute myocardial infarction in the myocardial area supplied by the target vessel within 2 weeks before the inclusion in the study.
  • The lesion can not be crossed with the guidewire and balloon angioplasty.
  • The vessel has been previously treated percutaneously.
  • The lesion is not suitable for a 2.25-3.5 coronary stent implantation.
  • The patient is not willing to undergo an angiographic follow-up.
  • The patient has contraindications for prolonged double (aspirin plus clopidogrel) anti-platelet therapy (e.g. allergy to aspirin, need for chronic oral anti-coagulation, or scheduled surgical intervention within 12 months.
  • Pregnancy or absence of pregnancy test in women of childbearing age.
  • Chronic renal failure (creatinine plasmatic values > 3.0 mg/dl).
  • Plasmatic platelet count < 100.000 mm-3 or > 700.000 mm-3.
  • The patient has a severe non-cardiac disease that limits his/her life expectancy to < 1 year.
  • The patient is currently included in other randomized trial.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Sirolimus-eluting stent
Implantation of sirolimus-eluting coronary stent
Device: Implantation of sirolimus-eluting coronary stent
Implantation of sirolimus-eluting coronary stent after dilatation of the coronary occlusion
Active Comparator: Everolimus-eluting stent
Implantation of everolimus-eluting coronary stent
Device: Implantation of everolimus-eluting coronary stent
Implantation of everolimus-eluting coronary stent after dilatation of the coronary occlusion

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
In-stent late lumen loss at 9-month angiographic follow-up
Time Frame: 9 months
9 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Angiographic: rate of binary angiographic restenosis, rate of vessel re-occlusion, and in-segment late loss, at 9 months
Time Frame: 9 and 12 months
9 and 12 months
Clinical: death, myocardial infarction, new revascularization, and angina status at 1 year.
Time Frame: 9 and 12 months
9 and 12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Raul Moreno

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2008

Primary Completion (Actual)

July 1, 2011

Study Registration Dates

First Submitted

November 17, 2008

First Submitted That Met QC Criteria

November 17, 2008

First Posted (Estimate)

November 19, 2008

Study Record Updates

Last Update Posted (Estimate)

June 19, 2012

Last Update Submitted That Met QC Criteria

June 18, 2012

Last Verified

June 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CIBELES (Other Identifier: Alias Study Number)
  • HHLP003

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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