The Genetics of Diabetes in Southern California Chinese Americans

Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort


Lead Sponsor: University of California, Irvine

Collaborator: Doris Duke Charitable Foundation

Source University of California, Irvine
Brief Summary

The purpose of this research study is to investigate the genetic causes of diabetes. Specifically, we are interested in the mitochondrial genome and how variants in the mitochondrial genome influence a person's risk to develop diabetes and metabolic syndrome.

Detailed Description

Since our laboratory's initial linkage of Type 2 diabetes to a mtDNA rearrangement in a three generation maternal pedigree 13 years ago, there has been increasing support for our hypothesis that mitochondrial dysfunction plays an important role in the etiology of Type 2 Diabetes Mellitus (DM) and the overlapping Metabolic Syndrome (MS). With this study we are planning an extensive investigation of defects in mitochondrial oxidative phosphorylation (OXPHOS) caused potentially by deleterious sequence variants in the mitochondrial DNA (mtDNA). As the primary objective we are trying to further substantiate 2 hypotheses: 1) that these diabetogenic mtDNA variants, which are proposed to range from recent, relatively severe, mutations will result in substantial OXPHOS defects with familial DM & MS and 2) that ancient, relatively mild polymorphisms result in partial OXPHOS defects and an increase in the risk to develop DM & MS.

Overall Status Unknown status
Start Date January 2006
Completion Date November 2010
Primary Completion Date November 2010
Study Type Observational
Enrollment 500

Sampling Method: Non-Probability Sample


Inclusion Criteria:

- Chinese or Taiwanese ancestry

- Resident of Southern California

- Age between 40 and 65

- Both people with and without diabetes are welcome to enroll.

Exclusion Criteria:

- Younger than 40 years or older than 65 years

- Ancestry is not Chinese or Taiwanese

- Not a resident of Southern California

Gender: All

Minimum Age: 40 Years

Maximum Age: 65 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Douglas C Wallace, PhD Principal Investigator UC Irvine Center for Mitochondrial Medicine
Overall Contact

Last Name: Julia Platt, MS

Phone: 949-824-9232

Email: [email protected]

Facility: Status: Contact: UC Irvine General Clinical Research Center Julia Platt, MS 949-824-9232 [email protected]
Location Countries

United States

Verification Date

February 2011

Responsible Party

Name Title: Douglas C. Wallace, Ph.D / Principal Investigator

Organization: UC Irvine Center for Mitochondrial Medicine and Genetics

Has Expanded Access No
Condition Browse
Arm Group

Label: 1

Description: Individuals with diabetes

Label: 2

Description: Individuals without diabetes

Study Design Info

Observational Model: Case-Control

Time Perspective: Cross-Sectional