Autonomic Nervous System Alteration Induce by Sepsis: Assessment and Prognosis Impact (SNA&Sepsis)

Autonomic Nervous System Alteration Induce by Sepsis:Assessment and Prognosis Impact

Severe sepsis and septic shock are causes of admission in intensive care units.Modification of natriuretic peptid including NT-proBNP and cardiac autonomic nervous system alteration are reported in sepsis shock and severe sepsis and seems to link to patient prognosis admitted to intensive care units.

Study Overview

• Status: Completed
• Conditions: Septic Shock; Severe Sepsis

Detailed Description

Our principal aim is to characterize modulation of cardiac sympathic nervous system in sepsis through the study of sinusal change and myocardiac fixing of MIBG.

The second aim is 1)to assess links between alteration of cardiac sympathic nervous system and NT-PRoBNP variations in sepsis and 2)To know prognostic impact in sympathic nervous system compare to NTproBNP.

• Study Type: Observational
• Enrollment (Actual): 13

Contacts and Locations

Study Locations

• France
  • Grenoble, France, 38000
    • University Hospital Grenoble

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All patient transfer in intensive care unit with sepsis chock or severe sepsis define as Bone criteria.

Description

Inclusion Criteria:

• Patient over 18 years admitted in intensive care unit and having severe sepsis criteria or septic shock documented or suspected define as Bone Criteria
• hemodynamically stable situation
• sinusal rhythm
• Patient for social security

Exclusion Criteria:

• Minors
• Patient under guardianship or trusteeship
• pregnant or lactating women
• diabetic
• cardiomyopathy known and/or treated or detect in admission
• electro-systolic process permanent or transitory
• neurological history or degenerative pathology
• chronic respiratory insufficiency
• Chronic renal insufficiency

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Sinusal variability analysis and myocardic fixation of MIBG performed in 48 hours post admission	48 hours post admission

Secondary Outcome Measures

Outcome Measure	Time Frame
plasmatic measure of NT-ProBNP and catecholamine at admission, day 2 and last day of hospitalisation	30 days

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Investigators: Principal Investigator: SCHWEBEL Carole, PH, Unit intensive care

Study record dates

Study Major Dates

• Study Start: October 1, 2008
• Primary Completion (Actual): September 1, 2011
• Study Completion (Actual): September 1, 2011

Study Registration Dates

• First Submitted: February 3, 2009
• First Submitted That Met QC Criteria: February 3, 2009
• First Posted (Estimate): February 4, 2009

Study Record Updates

• Last Update Posted (Estimate): January 19, 2015
• Last Update Submitted That Met QC Criteria: January 16, 2015
• Last Verified: July 1, 2010

More Information

Terms related to this study

• Keywords: Sepsis; Autonomic nervous system; severe sepsis; NTproBNP; Sepsis shock; sinusal change; Myocardiac fixing; Patient in intensive care unit with sepsis shock or severe
• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Systemic Inflammatory Response Syndrome; Inflammation; Sepsis; Toxemia
• Other Study ID Numbers: 06PHR04; 2008-A00453-52