- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00886054
The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients
December 20, 2009 updated by: National Taiwan University Hospital
The purpose of this study is to use transcranial Doppler (TCD) to predict intracranial pressure (ICP) and clinical outcome of neurocritical patients.
Study Overview
Status
Unknown
Detailed Description
Transcranial Doppler (TCD) and Transcranial color-coded duplex sonography (TCCS) play an important part in neurocritical monitoring systems.
Currently there are studies using flow velocities and pulsatility index (PI) to predict intracranial pressure (ICP) and clinical outcome.
But the use of B-mode in such prediction is not yet investigated.
The purposes of this study are to establish the correlation among clinical data, CT findings and information collected by TCCS, and to predict ICP and neurological outcome using such information.
The focus would be on 3rd ventricle size, midline shift and anteroposterior-transverse ration of midbrain (midbrain index) obtained by B-mode of TCCS.
This study is a prospective clinical study targeting on 30 neurocritical patients admitted to intensive care units in one year.
The timing of performance of TCCS will be (1) within 6 hours after admission, (2) within 6 hours after each CT examination, and (3) when ICP is higher than 20 mmHg for more than 5 minutes.
Glasgow coma scale (GCS), heart rate, blood pressure (systolic, diastolic, and mean), body temperature, central venous pressure (CVP), brain temperature, ICP, cerebral perfusion pressure (CPP), mean velocity (MV) of bilateral middle cerebral arteries (MCAs), PI, midline shift, 3rd ventricular dimension, anteroposterior to transverse ratio of midbrain (midbrain index, MI) are recorded.
The latter three parameters are also obtained from CT scans, and compared with those obtained from TCCS.
Outcome is evaluated with extended Glasgow outcome scale (GOSE), and analyzed with previous records.
This study is going to prove that TCCS is a safe, convenient, real-time and cheap tool in clinical care for neurocritical patients.
It also provides prediction of ICP and clinical outcome.
Study Type
Observational
Enrollment (Anticipated)
30
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan, 10002
- Department of Traumatology, National Taiwain University Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 80 years (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Patients admitted via emergency room for neurosurgical emergency, such as trauma, stroke, etc.
Description
Inclusion Criteria:
- Aged 16 to 80 years
- Neurocritical patient (head injury, hemorrhagic or ischemic stroke, subarachnoid hemorrhage, etc.) who was admitted to intensive care unit and had undergone intracranial pressure monitoring
Exclusion Criteria:
- associated with multiple organ impairment or failure
- single organ failure prior to neurocritical condition, such as cardiac, hepatic, or renal failure
- associated with severe infection or sepsis
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Neurocritical patients
Neurocritical patients including those sustaining head injury, cerebrovascular events (such as intracerebral hemorrhage, subarachnoid hemorrhage, etc.), brain tumor, or hydrocephalus.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Yi-Hsin Tsai, M.D., Department of Traumatology, National Taiwan University Hospital
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968 Jan;28(1):14-20. doi: 10.3171/jns.1968.28.1.0014. No abstract available.
- McQuire JC, Sutcliffe JC, Coats TJ. Early changes in middle cerebral artery blood flow velocity after head injury. J Neurosurg. 1998 Oct;89(4):526-32. doi: 10.3171/jns.1998.89.4.0526.
- Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg. 1982 Dec;57(6):769-74. doi: 10.3171/jns.1982.57.6.0769.
- Vahedi K, Vicaut E, Mateo J, Kurtz A, Orabi M, Guichard JP, Boutron C, Couvreur G, Rouanet F, Touze E, Guillon B, Carpentier A, Yelnik A, George B, Payen D, Bousser MG; DECIMAL Investigators. Sequential-design, multicenter, randomized, controlled trial of early decompressive craniectomy in malignant middle cerebral artery infarction (DECIMAL Trial). Stroke. 2007 Sep;38(9):2506-17. doi: 10.1161/STROKEAHA.107.485235. Epub 2007 Aug 9.
- Berland LL, Bryan CR, Sekar BC, Moss CN. Sonographic examination of the adult brain. J Clin Ultrasound. 1988 Jun;16(5):337-45. doi: 10.1002/jcu.1870160508.
- Bogdahn U, Becker G, Winkler J, Greiner K, Perez J, Meurers B. Transcranial color-coded real-time sonography in adults. Stroke. 1990 Dec;21(12):1680-8. doi: 10.1161/01.str.21.12.1680.
- Bor-Seng-Shu E, Hirsch R, Teixeira MJ, De Andrade AF, Marino R Jr. Cerebral hemodynamic changes gauged by transcranial Doppler ultrasonography in patients with posttraumatic brain swelling treated by surgical decompression. J Neurosurg. 2006 Jan;104(1):93-100. doi: 10.3171/jns.2006.104.1.93.
- Baussart B, Cheisson G, Compain M, Leblanc PE, Tadie M, Benhamou D, Duranteau J. Multimodal cerebral monitoring and decompressive surgery for the treatment of severe bacterial meningitis with increased intracranial pressure. Acta Anaesthesiol Scand. 2006 Jul;50(6):762-5. doi: 10.1111/j.1399-6576.2006.01038.x.
- Mitchell P, Gregson BA, Vindlacheruvu RR, Mendelow AD. Surgical options in ICH including decompressive craniectomy. J Neurol Sci. 2007 Oct 15;261(1-2):89-98. doi: 10.1016/j.jns.2007.04.040. Epub 2007 Jun 4.
- Tang SC, Huang SJ, Jeng JS, Yip PK. Third ventricle midline shift due to spontaneous supratentorial intracerebral hemorrhage evaluated by transcranial color-coded sonography. J Ultrasound Med. 2006 Feb;25(2):203-9. doi: 10.7863/jum.2006.25.2.203.
- Schmidt B, Klingelhofer J, Schwarze JJ, Sander D, Wittich I. Noninvasive prediction of intracranial pressure curves using transcranial Doppler ultrasonography and blood pressure curves. Stroke. 1997 Dec;28(12):2465-72. doi: 10.1161/01.str.28.12.2465.
- Newell DW, Aaslid R, Stooss R, Seiler RW, Reulen HJ. Evaluation of hemodynamic responses in head injury patients with transcranial Doppler monitoring. Acta Neurochir (Wien). 1997;139(9):804-17. doi: 10.1007/BF01411398.
- Shiogai T, Sato E, Tokitsu M, Hara M, Takeuchi K. Transcranial Doppler monitoring in severe brain damage: relationships between intracranial haemodynamics, brain dysfunction and outcome. Neurol Res. 1990 Dec;12(4):205-13. doi: 10.1080/01616412.1990.11739944.
- Marti-Fabregas J, Belvis R, Guardia E, Cocho D, Munoz J, Marruecos L, Marti-Vilalta JL. Prognostic value of Pulsatility Index in acute intracerebral hemorrhage. Neurology. 2003 Oct 28;61(8):1051-6. doi: 10.1212/01.wnl.0000090520.67254.14.
- Bouma GJ, Muizelaar JP. Cerebral blood flow in severe clinical head injury. New Horiz. 1995 Aug;3(3):384-94.
- Manno EM. Transcranial Doppler ultrasonography in the neurocritical care unit. Crit Care Clin. 1997 Jan;13(1):79-104. doi: 10.1016/s0749-0704(05)70297-9.
- Lindegaard KF, Nornes H, Bakke SJ, Sorteberg W, Nakstad P. Cerebral vasospasm diagnosis by means of angiography and blood velocity measurements. Acta Neurochir (Wien). 1989;100(1-2):12-24. doi: 10.1007/BF01405268.
- Klingelhofer J, Dander D, Holzgraefe M, Bischoff C, Conrad B. Cerebral vasospasm evaluated by transcranial Doppler ultrasonography at different intracranial pressures. J Neurosurg. 1991 Nov;75(5):752-8. doi: 10.3171/jns.1991.75.5.0752.
- Wozniak MA, Sloan MA, Rothman MI, Burch CM, Rigamonti D, Permutt T, Numaguchi Y. Detection of vasospasm by transcranial Doppler sonography. The challenges of the anterior and posterior cerebral arteries. J Neuroimaging. 1996 Apr;6(2):87-93. doi: 10.1111/jon19966287.
- McCartney JP, Thomas-Lukes KM, Gomez CR. Introduction to Transcranial Doppler. In: Handbook of transcranial Doppler. New York: Springer-Verlag, 1997;1-13.
- Baumgartner RW. Transcranial color-coded duplex sonography. J Neurol. 1999 Aug;246(8):637-47. doi: 10.1007/s004150050424.
- Lindegaard K-F. Indices of pulsatility. In: Newell DW, Aaslid RA, eds. Transcranial Doppler. New York: Raven Press, 1992:67-82.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2009
Primary Completion (Anticipated)
December 1, 2010
Study Completion (Anticipated)
December 1, 2010
Study Registration Dates
First Submitted
April 20, 2009
First Submitted That Met QC Criteria
April 21, 2009
First Posted (Estimate)
April 22, 2009
Study Record Updates
Last Update Posted (Estimate)
December 23, 2009
Last Update Submitted That Met QC Criteria
December 20, 2009
Last Verified
December 1, 2009
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Cardiovascular Diseases
- Vascular Diseases
- Cerebrovascular Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Wounds and Injuries
- Trauma, Nervous System
- Stroke
- Intracranial Hemorrhages
- Ischemic Stroke
- Hemorrhage
- Subarachnoid Hemorrhage
- Cerebral Hemorrhage
- Craniocerebral Trauma
- Hydrocephalus
Other Study ID Numbers
- 200901010R
- 97WFA0102463
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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