Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP)

Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP)

Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.

Study Overview

• Status: Unknown
• Conditions: Pneumonia; Sepsis; Bacteremia; Meningitis

• Study Type: Observational
• Enrollment (Anticipated): 300

Contacts and Locations

• Study Contact: Name: Ghassan S Dbaibo, M.D.; Phone Number: 5440 +961-1-749235; Email: gdbaibo@aub.edu.lb
• Study Contact Backup: Name: Carelle Tabet, RN; Phone Number: +961-3-860129; Email: cnt@aub.edu.lb

Study Locations

• Lebanon
  • Beirut, Lebanon, 113-6044
    • Recruiting
    • American University of Beirut
    • Contact: Ghassan S Dbaibo, M.D.; Phone Number: +961-1-749235; Email: gdbaibo@aub.edu.lb
    • Contact: Carelle Tabet, R.N.; Phone Number: +961-3-860129; Email: cnt03@aub.edu.lb
    • Principal Investigator: Ghassan S Dbaibo, M.D.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 day and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients with invasive pneumococcal disease with positive culture of S. pneumoniae from a normally sterile site (blood, CSF, etc.)

Description

Inclusion Criteria:

• Samples included in the study are those that are:

  • culture proven
  • invasive pneumococcal infections
  • in patients of all ages admitted to different hospitals all over Lebanon

• Acceptable samples include:

  • positive isolates from blood
  • cerebrospinal fluid
  • other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration

Exclusion Criteria:

• non S. pneumoniae isolates

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Serotype prevalence of S. pneumoniae in invasive pneumococcal disease	yearly

Secondary Outcome Measures

Outcome Measure	Time Frame
Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes	yearly

Collaborators and Investigators

• Sponsor: American University of Beirut Medical Center
• Collaborators: PneumoADIP
• Investigators: Principal Investigator: Ghassan S Dbaibo, M.D., American University of Beirut Medical Center

Study record dates

Study Major Dates

• Study Start: October 1, 2004
• Primary Completion (Anticipated): October 1, 2013
• Study Completion (Anticipated): October 1, 2014

Study Registration Dates

• First Submitted: May 8, 2009
• First Submitted That Met QC Criteria: May 13, 2009
• First Posted (Estimate): May 14, 2009

Study Record Updates

• Last Update Posted (Estimate): February 1, 2013
• Last Update Submitted That Met QC Criteria: January 31, 2013
• Last Verified: January 1, 2013

More Information

Terms related to this study

• Keywords: pneumonia; sepsis; meningitis; bacteremia; streptococcus pneumoniae; pneumococcus; serotypes
• Additional Relevant MeSH Terms: Pathologic Processes; Central Nervous System Diseases; Nervous System Diseases; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Lung Diseases; Systemic Inflammatory Response Syndrome; Inflammation; Bacterial Infections; Bacterial Infections and Mycoses; Sepsis; Pneumonia; Bacteremia; Meningitis
• Other Study ID Numbers: PNEUMOSurv1LIPSP