- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00915941
Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid (Pepsin)
Exploratory Study of Potential Pulmonary Aspiration Markers From Bronchoalveolar Lavage Fluid"
Study Overview
Status
Conditions
Detailed Description
This study is a single center, prospective, observational study of determining pepsin levels in BALF samples obtained from consecutive bronchoscopies at the Mayo Clinic Jacksonville. It is inherently an exploratory pilot study to confirm whether pepsin in BAL can act as a marker of gastric to pulmonary aspiration and whether specific association to pulmonary pathologies can be identified.
As an overview, all patients who are undergoing a bronchoscopy for clinical indications will be screened for potential participation in the study by obtaining BALF samples during the procedure for laboratory analyses. The BALF will then be tested for pepsin at the Thoracic Diseases Research Unit (Mayo Clinic Rochester) using a commercially available ELISA kit, and the ancillary markers will be analyzed per the clinical laboratory. Internal controls will be defined as normals when subjects have no lung dysfunction, no respiratory symptoms, and no lung parenchymal infiltrates on chest radiographs.
The primary aims of this project parallels the short-term hypotheses stated above:
- Confirm pepsin can be detected and quantitated in BALF obtained during a routine bronchoscopy.
- Identify specific pulmonary pathologies that are more often associated with increased pepsin BAL levels.
- Identify a normal range of pepsin in BALF in control normals.
- Identify any correlation of pepsin BAL levels with reflux, swallow, or respiratory symptoms (standardized questionnaires).
- Identify any correlation between pepsin BAL levels and lung function test or radiographic abnormalities.
Secondary aims of the study will include exploratory analyses of lesser defined potential aspiration markers including bilirubin, lipase, amylase, and pepsinogen. Analyses of these markers will parallel the analyses performed for pepsin.
The focus of the study is to:
- definitively identify whether pulmonary aspiration is occurring;
- quantitate the burden of aspiration that is occurring (i.e., dose);
- localize from where aspiration is occurring (e.g., gastric, duodenal, biliary, oropharyngeal, nasal);
- identify what is specifically being aspirated (e.g., acid, exogenous oils, bacteria, gastric contents, bile, gastric enzymes, pancreatic enzymes).
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Florida
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Jacksonville, Florida, United States, 32224
- Mayo Clinic
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Undergoing bronchoscopy for clinical reasons
- 21 years of age or older
- Ordering clinician and bronchoscopist is consenting
Exclusion Criteria:
- Emergent bronchoscopies
- Bronchoscopies performed in the operating room
- Pre-procedural oxygen requirement > 2 LPM for those who do not have a bronchoalveolar lavage ordered by the clinician as part of the bronchoscopy
- Pre-procedural bronchospasm for those who do not have a bronchoalveolar lavage ordered by the clinician as part of the bronchoscopy
- BAL is not requested for clinical reasons in a hospitalized or a mechanically ventilated patient
- The study coordinator, investigator, clinician, or the bronchoscopist may at any time withdraw the patient with regards to any concerns on patient safety or if there is concerns on the patient's or patient's surrogate's ability to give an informed consent
- The clinician or the bronchoscopist may at any time withdraw the patient if by participating in the study, the bronchoalveolar fluid obtained is felt to be inadequate for clinical testing
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Prospective
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 07-000550
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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