The Early Origins of Cardiovascular Disease : the Consequence of Growth Restriction During Foetal Life and Infancy on Cardiovascular Structure and Function in Adulthood

The Early Origins of Cardiovascular Disease

Sponsors

Lead sponsor: Danone Institute International

Source Danone Institute International
Brief Summary

Small body size at birth, slow weight gain during infancy and increase in body mass index after 2 years are independent risk factors for cardiovascular disease and the metabolic syndrome. There is a large gap in our understanding of how early growth affects the cardiovascular system. Possible mechanisms include alterations in body composition, in cardiac structure, in vascular function, in renal function and epigenetic processes.

The Objective is to determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics.

Overall Status Unknown status
Start Date June 2009
Study Type Observational
Primary Outcome
Measure Time Frame
To determine how size at birth and growth during infancy and childhood affect: body composition, cardiac structure and function, vascular and endothelial function, renal function, metabolic status and transcriptional and epigenetic characteristics 3 years
Enrollment 200
Condition
Eligibility

Sampling method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Male and female volunteers students aged between 18-25 years old

- Having growth records

Exclusion Criteria:

- If young women subject without contraception,or pregnant

Gender: All

Minimum age: 18 Years

Maximum age: 25 Years

Healthy volunteers: Accepts Healthy Volunteers

Overall Contact

Last name: Umberto SIMEONI, MD,PhD

Phone: 33 (0)4 91 38 40 30

Email: [email protected]

Location
facility contact CIC-UPCET Hopital de la Timone Bat F Olivier BLIN, MD +33 (0) 491 387 563 [email protected]
Location Countries

France

Verification Date

June 2009

Responsible Party

Name title: Dardaine /General representative

Organization: Danone Institute International

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Exposed/ Not exposed

Study Design Info

Observational model: Cohort

Time perspective: Retrospective

Source: ClinicalTrials.gov