- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00946244
A Longitudinal Study of Effectiveness of Early Intervention for Preterm Infants
February 21, 2017 updated by: National Taiwan University Hospital
The main purpose of this study is to extend the investigators' previous research to longitudinally examine the effectiveness of three early intervention programs: usual care program, clinic-based intervention program and home-based intervention program for very low birth weight preterm children at 3 and 4 years of age.
Normal weight full-term children will also be included to serve as the reference group.
Effectiveness assessments will include child, parenting, and transactions measures.
Child outcome measures will include health status, growth, neurodevelopment and behavior; parenting outcome measures will include parental stress, competence, efficacy and family support; transactions outcome measure will include parent-child interaction procedures.
Study Overview
Status
Completed
Conditions
Detailed Description
Accumulating data on early intervention for preterm infants illustrated short-term benefits on enhancing child development and decreasing parental stress, particularly for those of heavier birth weights.
However, rare studies had designed early intervention program for small preterm infants and longitudinally examined the effectiveness in various outcome domains.
Our research team recently conducted a clinical randomization trial on the effectiveness of three early intervention programs: usual care program (UCP), clinic-based intervention program (CBIP) and home-based intervention program (HBIP) on very low birth weight (VLBW, birth weight <1,500 g) preterm infants from the neonatal period to two years corrected age (CA).
The latter two were comprehensive, intensive intervention programs that combined child- and parent-focused services beginning in hospitalization and ending at one year CA as delivered at clinic and home respectively.
This three-year research project has extended our previous work to longitudinally examine the effectiveness of the three intervention programs in 180 VLBW preterm infants at 3 and 4 years of age.
Sixty full-term infants will also be included to serve as the reference group.
Outcome measures will include child (i.e., health, growth, neurodevelopment and behavior), parenting (i.e., parental stress, competency, efficacy and family support) and mother-child transactions (i.e., free-play and frustrating episode).
The longitudinal data on the effectiveness of these early intervention programs for VLBW preterm infants will provide important information to help early intervention professionals and public policy makers to develop effective intervention for preterm children at risk for developmental problems.
Study Type
Observational
Enrollment (Actual)
183
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan, 100
- National Taiwan University Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
3 years to 4 years (Child)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
Term and VLBW preterm children were born at the National Taiwan University Hospital and the Mackay Memorial Hospital (MMH)
Description
Inclusion Criteria:
- Body weight below 1501 gm
- Gestational age under 37 weeks
- Admission to the study hospitals within the first 7 days of life
- Singleton or the first child of twin or multiple births
- Physiologically stable at PCA 36 weeks as determined by attending physician
- Hospital discharge prior to PCA 44 weeks
Exclusion Criteria:
- Seizure
- Hydrocephalus
- Ventriculoperitoneal shunt
- Meningitis, periventricular leukomalacia
- Grade III to IV intraventricular hemorrhage
- Stage IV retinopathy of prematurity)
- Necrotizing enterocolitis with colostomy
- Severe cardiopulmonary disease requiring daily oxygen use at hospital discharge
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Term infants
Healthy term infants
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Usual care program
VLBW preterm infants who received usual medical care during hospitalization after birth
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Clinic-based intervention program
VLBW preterm infants who received specific early intervention program delivered at clinic before 1 year of corrected age (in previous study)
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Home-based intervention program
VLBW preterm infants who received specific early intervention program delivered at home before 1 year of corrected age (in previous study)
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Child's development (health, growth, neurodevelopment and behavior)
Time Frame: 3 and 4 years of age
|
3 and 4 years of age
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Parenting function (parent stress, competency, efficacy and family support)
Time Frame: 3 and 4 years of age
|
3 and 4 years of age
|
Parent-child transactions
Time Frame: 3 and 4 years of age
|
3 and 4 years of age
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2009
Primary Completion (Actual)
August 1, 2012
Study Completion (Actual)
August 1, 2012
Study Registration Dates
First Submitted
July 22, 2009
First Submitted That Met QC Criteria
July 23, 2009
First Posted (Estimate)
July 24, 2009
Study Record Updates
Last Update Posted (Actual)
February 23, 2017
Last Update Submitted That Met QC Criteria
February 21, 2017
Last Verified
November 1, 2009
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 200812114R
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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