Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients

December 12, 2018 updated by: Tampere University Hospital

Evaluating the Quality of Prehospital and In-hospital Cardio-pulmonary Resuscitation - Comparing the Compressions to Concurrent Vital Signs (Invasive Blood Pressure, Cerebral Oxygen Saturation, EtCO2) and Iatrogenic Injuries Associated to Chest Compressions.

The prognosis of cardiac arrest patients is generally poor. Recent studies have showed that the high quality of CPR increases the survival after cardiac arrest. Therefore the investigators planned this prospective observational study to determine the epidemiology of sudden cardiac arrest in the prehospital setting of Tampere area, the quality of the CPR, and also the associations between depth and frequency of chest compressions and invasive arterial pressure, EtCO2,cerebral oxygenation and iatrogenic injuries associated to chest compressions 1) in patients resuscitated out of hospital by emergency medical service's (EMS's) personals and 2) in-hospital by hospital resuscitation team members. In addition, the investigators will analyze the effects of the chosen method of resuscitation on critical vital signs (Etco2 and invasive pressures): closed-chest CPR is compared to open-chest CPR, or mechanical CPR with a device (AutoPulse-CPR, Cardio Pump) compared to manual CPR guided with quality CPR device. The results will give the investigators important insights into the haemodynamics of CPR which may guide future strategies for the management of cardiac arrest. The research group is also interested in CPR related injuries and mattress effect. Quality of life after CA is evaluated among survivals and the cause of death among non-survivors.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Anticipated)

1000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

      • Turku, Finland, 20100
        • Department of Anesthesiology and Intensive Care, Turku University Hospital
    • Pirkanmaa
      • Tampere, Pirkanmaa, Finland, 33521
        • Tampere University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Adult population >18 years of age with cardiac arrest

Description

Inclusion Criteria:

  • cardiac arrest
  • > 18 years of age

Exclusion Criteria:

  • < 18 years of age

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Cardiac arrest

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The success rate of current guidelines (depth and frequency of chest compression, epidemiology)
Time Frame: During the resuscitation
During the resuscitation
Quality of life after CA
Time Frame: 6 months
Quality of life after CA is usually fairly good measurement of quality of resuscitation attempt
6 months

Secondary Outcome Measures

Outcome Measure
Time Frame
Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2
Time Frame: During the resuscitation
During the resuscitation
survival of cardiac arrest
Time Frame: hospital discharge
hospital discharge

Other Outcome Measures

Outcome Measure
Time Frame
Change in hemodynamics, Change in cerebral saturation, Change in quality of CPR
Time Frame: During resuscitation
During resuscitation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Study Director: Jyrki Tenhunen, MD, PhD, Critical Care Medicine Research Group
  • Principal Investigator: Sanna Hoppu, MD, PhD, Tampere University Hospital
  • Principal Investigator: Marko Sainio, MD, Turku University Hospital
  • Study Director: Klaus Olkkola, MD, PhD, Department of Anesthesiology and Intensive Care, Helsinki University Hospital
  • Principal Investigator: Heidi Hellevuo, MD, Tampere University Hospital
  • Principal Investigator: Piritta Setälä, MD, Tampere University Hospital
  • Study Director: Ilkka Virkkunen, MD, PhD, Tampere University Hospital
  • Principal Investigator: Heidi Kangasniemi, MD, Tampere University Hospital
  • Principal Investigator: Joonas Tamminen, Tampere University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2008

Primary Completion (Actual)

December 1, 2015

Study Completion (Actual)

December 1, 2018

Study Registration Dates

First Submitted

July 31, 2009

First Submitted That Met QC Criteria

August 3, 2009

First Posted (Estimate)

August 4, 2009

Study Record Updates

Last Update Posted (Actual)

December 13, 2018

Last Update Submitted That Met QC Criteria

December 12, 2018

Last Verified

December 1, 2018

More Information

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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