- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01074905
Study on the Treatment of Vivax Malaria (VHX)
A Randomised Open Label Study Comparing the Efficacy of Chloroquine/Primaquine, Chloroquine and Artesunate in the Treatment of Vivax Malaria Along the Thai-Burmese Border
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Considerably less attention has been paid to Plasmodium vivax epidemiology than Plasmodium falciparum. In areas of relatively low unstable transmission, which comprise the majority of P.vivax affected areas, vivax malaria is predominantly a disease of children (Luxemburger et al 1999). Chloroquine has long been the standard treatment for vivax malaria. Primaquine is recommended for radical cure of vivax malaria, but is difficult to administer due to dosing duration and side effects.
This study aims to characterize the epidemiologic history comparing the efficacy of 3 antimalarial regimens (chloroquine, artesunate, and chloroquine/primaquine) for plasmodium vivax in western Thailand. Chloroquine is currently the standard of treatment for Plasmodium vivax. Due to the long half-life or chloroquine, the first relapse of vivax malaria may be delayed. In contrast, artesunate has a very short half-life, thus, having no impact on first relapse. It is not known whether chloroquine reduces the overall number of relapses, or only delays the first relapse. There are many important questions about the biology of vivax malaria of relevance to treatment that remain unanswered. For example is the number of relapses per infection (i.e. per successful inoculation) predetermined or adaptive? If it is predetermined then suppression of the first relapse (as with chloroquine, mefloquine or piperaquine) will reduce the total number of relapses and this is a clear benefit. If it is adaptive then these drugs will simply delay the relapses and there is less clear benefit. These various uncertainties illustrate the importance of detailed comparative longitudinal evaluations. In order to characterize the biology of vivax malaria, it will be necessary to compare regimens with and without primaquine. Because of the challenges that face primaquine prescription (side effects, toxicity in G6PD deficient patients and duration of treatment), it is not commonly deployed along the Thai Burma border. In effect, we will be comparing usual practice (non primaquine regimens) with the recommended WHO and Thai MOPH practice (use of primaquine for 14 days). The information we will gather is crucial to the understanding of chloroquine and its effect on the vivax parasite. This will lead to future studies and invariably change the way we treat vivax malaria.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
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Mae Sot, Thailand
- Shoklo Malaria Research Unit
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Adults and children > 6 months
- Weight > 7 kg for children
- Have not had primaquine since last Pv episode
- Participant (or parent/guardian if < 18 years old) is willing and able to give written informed consent
- Microscopic diagnosis of Plasmodium vivax mono-infection
- Ability (in the investigators opinion) and willingness of patient or parent/guardian to comply with all study requirements
Exclusion Criteria
- Allergy to artesunate, chloroquine or primaquine
- Severe malaria
- Patients with microscopic diagnosis of co-infection with Plasmodium falciparum
- Presence of any condition which in the judgement of the investigator would place the subject at undue risk or interfere with the results of the study
- Inability to tolerate oral medication
- Pregnancy
- Blood transfusion in the last 3 months
- Antimalarial in last 2 months
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Artesunate
2 mg/kg/day as single daily dose given for 5 days; maximum dose range is 1.6 to 2.4 mg/kg/day or a total of 8 to 12 mg/kg.
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2 mg/kg/day as single daily dose given for 5 days; maximum dose range is 1.6 to 2.4 mg/kg/day or a total of 8 to 12 mg/kg.
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Active Comparator: Chloroquine
25 mg base/kg given in divided doses (10,10,5) over 3 days; Absolute range 20-30 mg/kg.
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25 mg base/kg given in divided doses (10,10,5) over 3 days; Absolute range 20-30 mg/kg.
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Experimental: Chloroquine/Primaquine
Chloroquine 3 days and Primaquine 14 days
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Chloroquine 3 days and Primaquine 14 days
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The first recurrence of Plasmodium vivax malaria
Time Frame: Day 28
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The first recurrence of Plasmodium vivax malaria within 28 days
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Day 28
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Any recurrence of Plasmodium vivax parasitemia
Time Frame: 1 year
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Any recurrence of Plasmodium vivax parasitemia within the follow up period
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1 year
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Time to first recurrence, median time between episodes of vivax infections and total number of episodes
Time Frame: 1 year
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Time to first recurrence, median time between episodes of vivax infections and total number of episodes in the follow up period
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1 year
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Overall number of days of illness and haematocrit below 30%
Time Frame: 1 year
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Overall number of days of illness and haematocrit below 30% within the follow up period
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1 year
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Chloroquine level
Time Frame: Day 7
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Whole blood chloroquine level at day 7 and any day of recurrence of Plasmodium vivax malaria
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Day 7
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Adverse events
Time Frame: 1 year
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Adverse event profiles of artesunate, chloroquine and primaquine
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1 year
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Collaborators and Investigators
Sponsor
Collaborators
Publications and helpful links
General Publications
- Chu CS, Phyo AP, Lwin KM, Win HH, San T, Aung AA, Raksapraidee R, Carrara VI, Bancone G, Watson J, Moore KA, Wiladphaingern J, Proux S, Sriprawat K, Winterberg M, Cheah PY, Chue AL, Tarning J, Imwong M, Nosten F, White NJ. Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria. Clin Infect Dis. 2018 Oct 30;67(10):1543-1549. doi: 10.1093/cid/ciy319.
- Pratt B, Zion D, Lwin KM, Cheah PY, Nosten F, Loff B. Closing the translation gap for justice requirements in international research. J Med Ethics. 2012 Sep;38(9):552-8. doi: 10.1136/medethics-2011-100301. Epub 2012 Mar 16.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Infections
- Vector Borne Diseases
- Parasitic Diseases
- Protozoan Infections
- Malaria
- Malaria, Vivax
- Physiological Effects of Drugs
- Anti-Infective Agents
- Peripheral Nervous System Agents
- Antiviral Agents
- Analgesics
- Sensory System Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Antineoplastic Agents
- Antiprotozoal Agents
- Antiparasitic Agents
- Antimalarials
- Amebicides
- Filaricides
- Antinematodal Agents
- Anthelmintics
- Schistosomicides
- Antiplatyhelmintic Agents
- Chloroquine
- Chloroquine diphosphate
- Primaquine
- Artesunate
Other Study ID Numbers
- SMRU0908
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Shin Poong Pharmaceutical Co. Ltd.Recruiting
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