- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01306708
Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis
January 27, 2012 updated by: Anna Paula Piovezan, Universidade do Sul de Santa Catarina
Comparative Study Between Amitriptyline Regarding Nimesulide Associated to Nervous Blockade in the Acute Treatment of Idiopathic Adhesive Capsulitis
The adhesive capsulitis is a disease of the shoulder characterized by pain and limitation of movement amplitude.
It is defined as for etiology, having discordant theories that related it to an inflammatory condition or to an algoneurodystrophy process.
There is not yet a consensus about the best option of treatment.
The non-steroidal anti-inflammatories have analgesic and anti-inflammatory activity, where the mechanism of action is the inhibition of prostaglandin synthesis.
The antidepressants have been increasingly used in the control of chronic pain and the major action mechanism to have the analgesic effect seems to be based on inhibition of neurotransmitters reuptake noradrenaline and/or serotonin) in nerve cell endings.
Literature studies associate the practice of the nerve suprascapular blockade with anaesthetics to good results of clinical improvement of the pain, however, so far, no clinical studies comparing the efficacy of the non-steroidal antiinflammatories or tricyclic antidepressants to nervous blockage were registered in the acute treatment of adhesive capsulitis.
Study Overview
Study Type
Interventional
Enrollment (Actual)
34
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Santa Catarina
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Tubarão, Santa Catarina, Brazil, 88704-900
- Universidade do Sul de Santa Catarina
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Patients with clinical diagnostic of adhesive capsulitis, phase II, presenting shoulder pain,
- Limitation of anterior elevation for up to 130 degrees,
- Intact rotator cuff to magnetic resonance,
- Minimum loss of 50% of external rotation when compared to the contralateral side.
- Patients' acceptance of take part in the study after signing the FCCT.
Exclusion Criteria:
- Incapacity to fill the evaluation instrument;
- Contraindication to the use of local anaesthetics, non-steroidal anti-inflammatories or tricyclic antidepressants.
- Pregnancy and breastfeeding.
- Not follow the orientations during treatment on the weeks included in the study, such as, using other anaesthetics or procedures for the relief of pain in this period.
- Lesion of the rotator cuff, infection and others arthropathies.
- Inability to fill a protocol.
- Previous surgery on the shoulder.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: nimesulide
Nerve suprascapular blockade with local anaesthetic agent (novabupivacaine 0.25%, 10 ml, once per week) + oral non-steroidal anti-inflammatory (nimesulide 100 mg, twice per day, for 14 days);
|
Nerve suprascapular blockade with local anaesthetic agent (novabupivacaine 0.25%, 10 ml, once per week) + oral tricyclic antidepressant (amitriptyline 25 mg, twice per day, for 14 days);
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pain and disability of the shoulder
Time Frame: Days 0 and 14 after treatment begining
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Pain and disability of the shoulder, measured by the use of SPADI questionnaire.
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Days 0 and 14 after treatment begining
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Anna P Piovezan, Doctor, Universidade do Sul de Santa Catarina
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
February 1, 2011
Primary Completion (Actual)
July 1, 2011
Study Completion (Actual)
December 1, 2011
Study Registration Dates
First Submitted
March 1, 2011
First Submitted That Met QC Criteria
March 1, 2011
First Posted (Estimate)
March 2, 2011
Study Record Updates
Last Update Posted (Estimate)
January 31, 2012
Last Update Submitted That Met QC Criteria
January 27, 2012
Last Verified
September 1, 2011
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Joint Diseases
- Musculoskeletal Diseases
- Bursitis
- Physiological Effects of Drugs
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Analgesics, Non-Narcotic
- Psychotropic Drugs
- Neurotransmitter Uptake Inhibitors
- Membrane Transport Modulators
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Adrenergic Uptake Inhibitors
- Amitriptyline
Other Study ID Numbers
- 10.023.4.01.III
- 10.023.4.01 III (Other Identifier: Universidade do Sul de Santa Catarina)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Cairo UniversityRecruitingAdhesive Capsulitis of ShoulderEgypt
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