- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01423045
Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease
The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline.
Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity will be measured. The investigators will follow up kidney function decline and check if there is association with urine osmolarity.
Study Overview
Status
Conditions
Detailed Description
Design:
Prospective observational study
Setting:
Predialysis clinic.
Participants:
We will include adults >18 years providing signed informed consent.
Inclusion:
Patients with CKD and estimated GFR of less then 50 mL per minute estimated by the short MDRD equation base on two creatinine values taken at least two weeks apart and are not getting steroids or immunosuppressive medication as treatment for their primary kidney disease.
Exclusion:
- Life expectancy of less then 6 month.
- Expected to start renal replacement therapy within 3 month.
- Acute or acute on chronic renal failure with reversible component.
- Treatment with AVP inhibitors.
- Chronic hyponatremia (Na+<135 in two measurement two weeks apart).
- Primary polydipsia.
- Inability to give informed consent.
- Clinical hypovolemia.
Outcomes:
Primary outcomes:
Rate of GFR decline as assessed by short MDRD equation with at least three measurements at least three month apart.
. Secondary efficacy
- Rate of ESKD define as need RRT.
- Overall mortality.
- ESKD and overall mortality.
- Blood pressure as assessed by clinic measurement.
- Protein creatinine ratio in random urine sample.
- Hemoglobin level.
- Need for erythropoietin treatment.
- Blood level of 25OH vitamin D and 1,25OH vitamin D.
- PTH, calcium and phosphate level.
- The occurrence of edema by physical evaluation.
Predefined subgroup analysis:
- Diabetic patients.
- Patients treated with diuretics.
Sample size:
We will need to recruit about 200 patients.
Statistical methods:
We will use linear regression analysis with 95% CI for the continuous variable. And chi square for dichotomous variable.
Data collection and trial flow:
All patients in predialysis clinic of Dan district of "Kupat holim clalit" will be screen. Patients fulfilling inclusion criteria will be approached by trial investigator for informed consent and trial recruitment. For patients fulfilling inclusion criteria that will not consent to participate we will be record name and ID without further details. Consenting patients will bring the three samples of first voided urine of the morning for osmolarity, PH, sodium, potassium and chloride.
Patient recruitment:
Baseline data collection:
Collection of data will include baseline conditions, primary kidney disease, current medications, clinical evaluation for edema and blood pressure.
Laboratory results will include creatinine, urea, sodium, potassium, GFR assessed by short MDRD equation, protein creatinine ratio in random urine sample Hb level, vitamin D level calcium, phosphorus and PTH.
Follow-up and outcome data collection:
- Creatinine, estimated GFR, urea, sodium, potassium chloride, hemoglobin and protein creatinine ratio in random urine sample at least every three month
- Clinical assessment for edema and blood pressure ant least every three month.
- Time to initiation of dialysis or transplantation.
- Mortality of any cause and cardiovascular mortality.
- Hospitalization for any cause and the length of hospital stay.
- The need for ESA treatment and ESA dose will be recorded.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Locations
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-
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Ganey Tiqua, Israel, 55900
- Pre dialysis clinic Dan Petach Tiqua county General health service
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Contact:
- Benaya Rozen-zvi, MD
- Phone Number: 050-8773766
- Email: benayarz@gmail.com
-
Contact:
- Boris Zingerman, MD
- Phone Number: 050-6260428
- Email: borisz@clalit.org.il
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients with CKD and estimated GFR of less then 50 mL per minute estimated by the short MDRD equation base on two creatinine values taken at least two weeks apart and are not getting steroids or immunosuppressive medication as treatment for their primary kidney disease.
Exclusion Criteria:
- Life expectancy of less then 6 month.
- Expected to start renal replacement therapy within 3 month.
- Acute or acute on chronic renal failure with reversible component.
- Treatment with AVP inhibitors.
- Chronic hyponatremia (Na+<135 in two measurement two weeks apart).
- Primary polydipsia.
- Inability to give informed consent.
- Clinical hypovolemia.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
eGFR slope
Time Frame: 12 month
|
Creatinnie value will be measured at least every three month and eGFR will be calculated by MDRD equation.
A regression line will be plotted against time and the eGFR slope will be calculated.
|
12 month
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Benaya Rozen-Zvi, MD, General health services - Dan Petach tiqua county
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UCONC
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