Relationship Between Tissue Markes in Patients With Post Cardio Respiratory Syndrome

Relationship Between Lactate and Venous Oxygen Saturation Gradient of Carbon Dioxide in Patients With Post Cardio Respiratory Syndrome

There is a correlation between hospital mortality and changes in markers of tissue perfusion, lactate, and venous oxygen saturation and carbon dioxide gradient.

Study Overview

• Status: Unknown
• Conditions: Cardiac Arrest

Detailed Description

Evaluation of the serum carbon dioxide gradient (GapCO2), central venous saturation (ScvO2) and the clearance of serum lactate (Clac) in predicting hospital mortality after cardiac arrest syndrome (post-PCR).

Prospective study, unicenter - Intensive Care Unit - HNSC. Period: May/2010 to June/2011. Serial assessment of GapCO2 of ScvO2 Clac and the first 72 hours post-PCR. Excluded under 18, survival of less than 6HS, pregnant women, traumatized, post-operative hypothermia and liver disease. T-student test, 95% (p <0.05).

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

• Study Contact: Name: Vanessa M Oliveira, MD; Phone Number: 05192513723; Email: vanessa.oliveira480@gmail.com
• Study Contact Backup: Name: Diego Riveiro, MD; Phone Number: 05184175632; Email: dmriveiro@yahoo.com.br

Study Locations

• Brazil
  • Rio Grande do Sul
    • Porto Alegre, Rio Grande do Sul, Brazil
      • Recruiting
      • Conceição Hospital
      • Principal Investigator: Vanessa Oliveira, MD
      • Principal Investigator: Diego Riveiro, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

patients hospitalized in the intensive care unit after cardiopulmonary arrest

Description

Inclusion Criteria:

• All patients hospitalized in the intensive care unit after cardiopulmonary arrest with any pace

Exclusion Criteria:

pregnant women, traumatized, post-operative(less 7 days), hypothermia and liver disease.

• patients hospitalized in the intensive care unit with more than 6 hours post cardiac arrest
• less 18 years old

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
all patients after cardiac arrest

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
mortality	1 year

Secondary Outcome Measures

Outcome Measure	Time Frame
correlation of clearance markers of perfusion with the use of vasopressor and positive fluid balance	6 hours

Collaborators and Investigators

• Sponsor: Hospital Nossa Senhora da Conceicao
• Investigators: Principal Investigator: Vanessa Oliveira, MD, Conceição Hospital; Principal Investigator: Diego F Riveiro, MD, Hospital Nossa Senhora da Conceição

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (Anticipated): December 1, 2011
• Study Completion (Anticipated): December 1, 2011

Study Registration Dates

• First Submitted: September 28, 2011
• First Submitted That Met QC Criteria: October 19, 2011
• First Posted (Estimate): October 20, 2011

Study Record Updates

• Last Update Posted (Estimate): November 3, 2011
• Last Update Submitted That Met QC Criteria: November 2, 2011
• Last Verified: November 1, 2011

More Information

Terms related to this study

• Keywords: cardiac arrest
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Arrest
• Other Study ID Numbers: 10086