Effects of Glucose-fructose Drinks During Training on Lactate Transport (LactEx)

June 3, 2014 updated by: Luc Tappy, MD, University of Lausanne

Effects of Glucose-fructose Drinks During Training on Lactate Transport and Oxidation and on Endurance Performance

The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.

Study Type

Interventional

Enrollment (Actual)

17

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
    • Vaud
      • Lausanne, Vaud, Switzerland, 1005
        • University of Lausanne

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 30 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • healthy
  • age between 18 and 30 years
  • sedentary
  • BMI between 19 and 25
  • blood pressure lower than 140/90 mmHg

Exclusion Criteria:

  • smoking
  • consumption of more than 10g alcohol per day
  • cardiovascular history
  • electrographic abnormalities at rest
  • consumption of more than one can of soda per day or more than 60g sugars per day
  • any current drug treatment
  • consumption of drugs or illicit substances
  • diabetes mellitus
  • vegetarian
  • food intolerance
  • blood donation or participation to another study <3 months before study inclusion

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Glucose-fructose
Participants will take glucose-fructose drinks during training sessions
Dietary supplement: Glucose-fructose
0.8 g/h glucose and 0.5 g/h fructose during training
Experimental: Water
Participants will take only water during training sessions
Dietary supplement: Water
Only water intake during training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in lactate transport
Time Frame: At baseline (before training) and after the 3-week training protocol
Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)
At baseline (before training) and after the 3-week training protocol

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in muscle monocarboxylate transporters (MCTs) expression and protein content
Time Frame: At baseline (before training) and after the 3-week training protocol
MCTs expression (mRNA) and protein content after muscle biopsy
At baseline (before training) and after the 3-week training protocol

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Lausanne

Collaborators

Centre Hospitalier Universitaire Vaudois

Investigators

  • Principal Investigator: Luc Tappy, Pr, University of Lausanne

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2012

Primary Completion (Actual)

March 1, 2014

Study Completion (Actual)

March 1, 2014

Study Registration Dates

First Submitted

May 23, 2012

First Submitted That Met QC Criteria

May 30, 2012

First Posted (Estimate)

June 4, 2012

Study Record Updates

Last Update Posted (Estimate)

June 4, 2014

Last Update Submitted That Met QC Criteria

June 3, 2014

Last Verified

June 1, 2014

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 251/11

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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