Comparison of Efficacy of Ivabradine Versus Metoprolol

Comparison of Efficacy and Safety of Ivabradine Versus Metoprolol for Controlling Heart Rate Prior to 640-Slice Computed Tomographic Angiography in Elective Patients

Sponsors

Lead Sponsor: Col. Suthee Panichkul

Collaborator: Phramongkutklao College of Medicine and Hospital

Source Phramongkutklao College of Medicine and Hospital
Brief Summary

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Overall Status Unknown status
Start Date December 2014
Completion Date December 2015
Primary Completion Date December 2014
Phase Phase 4
Study Type Interventional
Primary Outcome
Measure Time Frame
Heart rate of patient before CT coronary 1 January 2013 to 31 december 2013
Secondary Outcome
Measure Time Frame
safety and side effect of Metoprolol and Ivabradine 1 january 2013 to 31 december 2013
Enrollment 60
Condition
Intervention

Intervention Type: Drug

Intervention Name: Ivabradine and Metoprolol

Eligibility

Criteria:

Inclusion Criteria:

- elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital

- Resting heart rate > 70 BPM

- age > 18 years and informed consent

Exclusion Criteria:

- Heart rate > 100 BPM

- BP <100/60 mmHg

- recent congestive heart failure in 1 mo.

- SA node, AV node disease and AF

- on permanent pacemaker

- CrCL < 15ml/min. , AST or ALT > 3x UNL

- on HR reducing drug such as diltiazem, verapamil, digitalis

- contraindication for ivabradine or metoprolol

Gender: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Purich - Surunchupakorn, M.D. Principal Investigator Phramongkutklao College of Medicine and Hospital
Overall Contact

Last Name: Purich Surunchupakorn, M.D.

Phone: 081-988-7390

Email: [email protected]

Location
Facility: Contact: Investigator: Phramonkutklao Hospital Purich Surunchupakorn, M.D. 081-988-7390 [email protected] Purich - Surunchupakorn, M.D. Principal Investigator
Location Countries

Thailand

Verification Date

October 2014

Responsible Party

Type: Sponsor-Investigator

Investigator Affiliation: Phramongkutklao College of Medicine and Hospital

Investigator Full Name: Col. Suthee Panichkul

Investigator Title: Col. Suthee Panichkul

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: Ivabradine

Type: Experimental

Description: Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol

Label: metoprolol

Type: Active Comparator

Description: Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine

Acronym IMAGE
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Diagnostic

Masking: Double (Participant, Care Provider)

Source: ClinicalTrials.gov