Early Waning of Maternal Measles and Meningitis C Antibodies (EWMM)

September 16, 2014 updated by: Guangzhou Center for Disease Control and Prevention

Observation Study on Early Waning of Maternal Measles and Meningitis C Antibodies

Maternal antibodies (measles and meningitis C) may wane in the first six months after birth.

  • Geometric mean titers(GMTs) of measles and meningitis C.
  • Follow-up on 0 month, 3rd month,5th month and 7th month after birth.

Study Overview

Status

Unknown

Conditions

Detailed Description

Measles and meningitis C are hot topics in China in recent years. Although China had set the goal of measles elimination, many measles cases were found to be those aged < 8 months and meningitis C is becoming public health issue since meningitis group A has been controlled at a very low level and little is known on C group. So the investigators designed the observation study on the two antibodies.

Maternal antibodies are supposed to wane after birth. Serums of the placenta(0 month), children of 3 months, 5 months and 7 months old will be collected and the geometric mean titers (GMTs) of measles and meningitis C will be confirmed by using the ELISA test.

Study Type

Observational

Enrollment (Anticipated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Guangdong
      • Guangzhou, Guangdong, China, 510440
        • Recruiting
        • Guangzhou Center for Disease Control and Prevention
        • Contact:
          • Chuanxi
          • Phone Number: +86 20 36055887
        • Contact:
        • Sub-Investigator:
          • Long Lu, MPH

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

No older than 7 months (Child)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Infants.

Description

Inclusion Criteria:

  • Healthy infants.

Exclusion Criteria:

  • Infants with poor score.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
GMT

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Geometric Mean Titer
Time Frame: Up to six months
Up to six months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Guangzhou Center for Disease Control and Prevention

Investigators

  • Principal Investigator: Ming Wang, Guangzhou CDC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2014

Primary Completion (Anticipated)

October 1, 2014

Study Completion (Anticipated)

December 1, 2014

Study Registration Dates

First Submitted

August 13, 2014

First Submitted That Met QC Criteria

August 14, 2014

First Posted (Estimate)

August 18, 2014

Study Record Updates

Last Update Posted (Estimate)

September 18, 2014

Last Update Submitted That Met QC Criteria

September 16, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • GZCDC001

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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