The Regional Cerebral Oxygen Saturation and Both S100B and GFAP Proteins Serum Concentration in Patients Undergoing Primary Hip Arthroplasty.
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Lead sponsor: Military Institute of Medicine, Poland
|Source||Military Institute of Medicine, Poland|
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear. The role of thromboembolic events in etiology of POCD was discussed. The incidence of such events in patients who underwent big joints arthroplasty can be as high as 40 to 60%, although some cases are subclinical. Thromboembolic material can block a blood flow through a vessels in the brain. As a consequence cerebral neurons can be damaged or destroyed. After neuronal damage specific substances, such as S100B protein, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) are released to the blood. The serum concentrations of these biomarkers can be measured. Moreover, the block of blood flow will decrease regional cerebral saturation in affected parts of the brain.
In this project the authors would like to analyze the correlation between the regional cerebral saturation and serum concentration of both S100B protein and GFAP in orthopedic patients scheduled to primary hip arthroplasty.
|Start Date||June 2014|
|Completion Date||December 2015|
|Primary Completion Date||December 2015|
Intervention type: Device
Intervention name: cemented or cementless type of hip prothesis
Inclusion Criteria: - patient scheduled to primary hip arthroplasty, - orthopedic procedure under spinal anesthesia. Exclusion Criteria: - patients younger than 18 y.o., - surgery under general anesthesia, - patients who refused to participate in the study.
- patient scheduled to primary hip arthroplasty,
- orthopedic procedure under spinal anesthesia.
- patients younger than 18 y.o.,
- surgery under general anesthesia,
- patients who refused to participate in the study.
Minimum age: 18 Years
Maximum age: N/A
Healthy volunteers: No
Responsible party type: Principal Investigator
Investigator affiliation: Military Institute of Medicine, Poland
Investigator full name: Dariusz Tomaszewski
Investigator title: M.D., Ph.D.
|Has Expanded Access||No|
|Number Of Arms||2|
Arm group label: cemented
Arm group type: Other
Description: Primary hip arthroplasty with bone cement use.
Arm group label: cementless
Arm group type: Other
Description: Primary hip arthroplasty without bone cement use.
|Study Design Info||
Intervention model: Parallel Assignment
Primary purpose: Diagnostic
Masking: Single (Participant)