Tonsillectomy and Primitive IgA Nephropathy in Children: Strasbourg Cohort and Assessment Practices in Inter North East Region

Primitive kidney disease IgA, represented by Berger's disease and rheumatoid purpura nephropathy, are the first cause of kidney failure from chronic glomerulonephritis: changes in 20 years to end-stage renal failure is described in 10 to 30 % of cases in Berger's disease and in 15 to 20% of cases in nephropathy HSP. These two pathological entities share biological and histological characteristics, as well as common pathophysiological mechanisms, particularly the production of abnormally glycosylated IgA1 promoting their proliferation in the mesangium. Tonsils part of Iga abnormal production sites that would be associated with an infectious stimulus, tonsillectomy has been studied as a possible treatment in primitive IgA nephropathy. The benefit of tonsillectomy is controversial: many Japanese studies demonstrate its effectiveness in terms of reduction of proteinuria, improved renal function in the long term regression of histological lesions and reduced risk of relapse following clinical remission whereas European studies do not suggest its effectiveness in treating IgA nephropathy. In this context, the aim of our study is to describe the scope of practice of tonsillectomy in the treatment of primary renal disease in IgA child in the inter East region and describe the short renal become Strasbourg end of the cohort that received this treatment.

Study Overview

• Status: Unknown
• Conditions: Tonsillectomy

• Study Type: Observational
• Enrollment (Anticipated): 20

Contacts and Locations

• Study Contact: Name: Laetitia HIGEL, MD; Phone Number: 33 (0)3.88.12.77.40; Email: laetitia.higel@chru-strasbourg.fr
• Study Contact Backup: Name: Eléonore FEUGEAS, MD; Phone Number: 33 (0)3.88.12.77.40; Email: Eleonore.feugeas@chru-strasbourg.fr

Study Locations

• France
  • Strasbourg, France, 67098
    • Recruiting
    • Service de Pédiatrie 1 Hôpital de Hautepierre
    • Sub-Investigator: Eléonore FEUGEAS, MD
    • Contact: Laetitia HIGEL, MD; Phone Number: 33 (0)3.88.12.77.40; Email: laetitia.higel@chru-strasbourg.fr
    • Contact: Eléonore FEUGEAS, MD; Phone Number: 33 (0)3.88.12.77.40; Email: Eleonore.feugeas@chru-strasbourg.fr
    • Principal Investigator: Laetitia HIGEL, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Children with a clinical diagnosis and / or histological evidence of primary IgA nephropathy

Description

Inclusion criteria:

• Children with a clinical diagnosis and / or histological evidence of primary IgA nephropathy
• Follow the University Hospital of Strasbourg since 2009
• Having received a tonsillectomy in their care
• Children whose holders of parental authority does not oppose the use of clinical data from their child for research purposes

Exclusion criteria:

• Children whose holders of parental authority are opposed to the use of clinical data from their child for research purposes

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Evaluation of the management of the tonsillectomy at the CHU of Strasbourg by a standardized questionnaire	since January 2009

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Study Director: Laetitia HIGEL, MD, University Hospital, Strasbourg, France

Study record dates

Study Major Dates

• Study Start (Actual): April 1, 2016
• Primary Completion (Anticipated): September 1, 2017
• Study Completion (Anticipated): September 1, 2017

Study Registration Dates

• First Submitted: June 16, 2016
• First Submitted That Met QC Criteria: July 7, 2016
• First Posted (Estimate): July 12, 2016

Study Record Updates

• Last Update Posted (Actual): May 23, 2017
• Last Update Submitted That Met QC Criteria: May 19, 2017
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Keywords: Tonsillectomy; kidney failure; IgA; primary IgA nephropathy; primary nephropathy; Berger's disease; Purpura rheumatoid
• Additional Relevant MeSH Terms: Immune System Diseases; Autoimmune Diseases; Urologic Diseases; Nephritis; Glomerulonephritis; Kidney Diseases; Glomerulonephritis, IGA
• Other Study ID Numbers: 6402

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO