- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02838927
Survey on Epidemiology of Hypoparathyroidism in France (Epi-Hypo)
September 7, 2023 updated by: Jean-philippe Bertocchio, MD, PhD, European Georges Pompidou Hospital
Epi-Hypo: Survey on Epidemiology of Hypoparathyroidism in France
Very few data has been published on the epidemiology of hypoparathyroidism worldwide: none exists specifically for France.
Hypoparathyroidism could led to complications.
Here, the investigators plan to collect data about both epidemiology, medication and complication of hypoparathyroidism in France.
Study Overview
Detailed Description
Very few data has been published on the epidemiology of hypoparathyroidism worldwide.
None exists specifically in France.
Hypoparathyroidism could led to complications: e.g.
symptomatic hypocalcemia, calcifications (brain, eye and other soft tissues), nephrolithiasis/nephrocalcinosis, renal insufficiency.
Here,the investigators plan to collect data about both epidemiology, medication and complication of hypoparathyroidism in France.
Study Type
Observational
Enrollment (Estimated)
1000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jean-Philippe Bertocchio, MD, PhD
- Phone Number: (+33)156095625
- Email: jpbertocchio@gmail.com
Study Contact Backup
- Name: Pascal Houillier, MD, PhD
- Phone Number: (+33)156095625
- Email: pascal.houillier@aphp.fr
Study Locations
-
-
-
Aix-en-Provence, France, 13100
- Recruiting
- Hôpital Privé de Provence
-
Contact:
- Nicolas Dervaux, MD
-
Amiens, France, 80054
- Recruiting
- Amiens university hospital
-
Contact:
- Rachel Desailloud, MD
- Email: desailloud.rachel@chu-amiens.fr
-
Auch, France
- Recruiting
- Clinic Auch Area
-
Contact:
- Stéphane Castillo-Ros, MD
- Phone Number: 33562051340
- Email: stephane.castillo-ros@wanadoo.fr
-
Aurillac, France
- Recruiting
- Henri Mondor Hospital
-
Contact:
- Emmanuelle Dubosclard-Laguerre, MD
- Phone Number: 33471465658
- Email: e.dubosclard@ch-aurillac.fr
-
Besançon, France
- Recruiting
- Jean Minjoz Hospital
-
Contact:
- Sophie Borot, MD
- Phone Number: 33381668166
- Email: sophie.borot@univ-fcomte.fr
-
Bobigny, France, 93000
- Recruiting
- Avicenne Hospital, AP-HP
-
Contact:
- Lucie Allard, MD
- Email: lucie.allard@aphp.fr
-
Bondy, France
- Recruiting
- Jean Verdier Hospital, AP-HP
-
Contact:
- Paul Elie Valensi, MD, PhD
- Phone Number: 331 48 95 51 51
- Email: paul.valensi@aphp.fr
-
Bordeaux, France
- Recruiting
- University Hospital
-
Contact:
- Antoine Tabarin, MD, PhD
- Phone Number: 335 24 54 90 08
- Email: antoine.tabarin@chu-bordeaux.fr
-
Sub-Investigator:
- Renaud de La Faille, MD, PhD
-
Bourgoin-Jallieu, France
- Recruiting
- Bourgoin Jallieu Hospital
-
Contact:
- Louis De Laforcade, MD
- Email: ldelaforcade@gmail.com
-
Brest, France
- Recruiting
- La Cavale Blanche Hospital
-
Contact:
- Morgane Gosselin, MD
- Phone Number: 332 98 34 70 74
- Email: morgane.gosselin@gmail.com
-
Sub-Investigator:
- Véronique Kerlan, MD
-
Caen, France
- Recruiting
- Côte de Nacre Hospital
-
Contact:
- Yves Reznik, MD, PhD
- Phone Number: 33231064575
- Email: reznik-y@chu-caen.fr
-
Créteil, France
- Recruiting
- Henri Mondor Hospital, APHP
-
Contact:
- Thomas Stehle, MD
- Phone Number: 33149812457
- Email: thomas.stehle@aphp.Fr
-
Sub-Investigator:
- Céline Droumaguet, MD
-
Dax, France
- Recruiting
- Dax-Côte d'Argent Hospital
-
Contact:
- Emmanuelle Bourrinet, MD
- Phone Number: 33558914848
- Email: bourrinete@ch-dax.fr
-
Dijon, France
- Recruiting
- University Hospital
-
Contact:
- Sylvie Picard, MD
- Phone Number: 33380702090
- Email: doc.sylvie.picard.md@orange.fr
-
Sub-Investigator:
- Bruno Vergès, MD, PhD
-
Grenoble, France
- Recruiting
- Grenoble Alpes Hospital
-
Contact:
- Olivier Chabre, MD, PhD
- Phone Number: 33476765509
- Email: olivierchabre@chu-grenoble.fr
-
La Roche-sur-Yon, France, 85925
- Recruiting
- CHD Vendée
-
Contact:
- Anne-Hélène Querard, MD
- Email: anne-helene.querard@chd-vendee.fr
-
Le Kremlin-Bicêtre, France
- Recruiting
- Kremlin-Bicêtre Hospital, APHP
-
Contact:
- Agnès Linglart, MD, PhD
- Phone Number: 33145217846
- Email: agnes.linglart@aphp.fr
-
Sub-Investigator:
- Peter Kamenicky, MD, PhD
-
Le Mans, France
- Recruiting
- Le Mans hospital
-
Contact:
- Anne Dorange, MD
- Phone Number: 33243479933
- Email: anne.recton@neuf.fr
-
Libourne, France
- Recruiting
- Libourne Hospital
-
Contact:
- Adrien Keller, MD
- Phone Number: 33557553462
- Email: adrien.keller@ch-libourne.fr
-
Lille, France
- Recruiting
- Claude Huriez Hospital
-
Contact:
- Marie-Christine Vantyghem, MD, PhD
- Phone Number: 33320445962
- Email: mc-vantyghem@chru-lille.fr
-
Lyon, France
- Recruiting
- Edouard Herriot Hospital, HCL
-
Contact:
- Sandrine Lemoine, MD, PhD
- Phone Number: 33437538062
- Email: sandrine.lemoine01@chu-lyon.fr
-
Sub-Investigator:
- Justine Bacchetta, MD, PhD
-
Marseille, France
- Recruiting
- La Conception Hospital, AP-HM
-
Contact:
- Thierry Brue, MD, PhD
- Email: Thierry.BRUE@ap-hm.fr
-
Sub-Investigator:
- Mickaël Bobot, MD
-
Sub-Investigator:
- Marion Pelletier, MD
-
Metz, France
- Recruiting
- Clinic Metz Area
-
Contact:
- Valérie Aubert, MD
- Phone Number: 33387358132
- Email: dr.valerie.aubert@orange.fr
-
Metz, France
- Recruiting
- Mercy Hospital
-
Contact:
- Benjmain Savenkoff, MD
- Phone Number: 33387345100
- Email: benjamin.savenkoff@gmail.com
-
Montpellier, France
- Recruiting
- Arnaud de villeneuve Hospital
-
Contact:
- Cyril Amouroux, MD
- Phone Number: 33467336733
- Email: cyril-amouroux@chu-montpellier.fr
-
Sub-Investigator:
- Isabelle Raingeard, MD
-
Mérignac, France
- Recruiting
- Clinic Area
-
Contact:
- Anne Navaranne-Roumec, MD
- Email: docteur.navarranne-roumec@orange.fr
-
Nancy, France
- Recruiting
- Brabois Hospital
-
Contact:
- Marc Klein, MD, PhD
- Phone Number: 33383153030
- Email: m.klein@chru-nancy.fr
-
Nantes, France
- Recruiting
- University Hospital
-
Contact:
- Lucile Figueres, MD, PhD
- Phone Number: 33240087453
- Email: lucile.figueres@chu-nantes.fr
-
Nice, France, 06200
- Recruiting
- University Hospital
-
Contact:
- Nicolas Chevalier, MD, PhD
-
Sub-Investigator:
- Eléanore Fagot, MD
-
Sub-Investigator:
- Sylvie Hieronimus, MD
-
Sub-Investigator:
- Valentina Pautasso, MD
-
Sub-Investigator:
- Sylvie Nicolau-Langlade, MD
-
Sub-Investigator:
- Anne-Gaëlle Decoux-Poullot, MD
-
Sub-Investigator:
- Stéphanie Telo, MD
-
Sub-Investigator:
- Marie Hoflack, MD
-
Niort, France, 79000
- Recruiting
- Georges Renon Hospital
-
Contact:
- Claire Laurent, MD
- Phone Number: +335 49 32 79 79
- Email: claire.laurent@ch-niort.fr
-
Nîmes, France
- Recruiting
- Caremeau hospital
-
Sub-Investigator:
- Olivier Gilly, MD
-
Contact:
- Sophie Renaud, MD, PhD
- Phone Number: 33466686868
- Email: sophie.renaud@chu-nimes.fr
-
Sub-Investigator:
- Olivier Moranne, MD, PhD
-
Paris, France, 75908
- Recruiting
- European Georges Pompidou Hospital, APHP
-
Contact:
- Jean-Philippe Bertocchio, MD, PhD
- Phone Number: (+33)156095625
- Email: jpbertocchio@gmail.com
-
Contact:
- Pascal Houillier, MD, PhD
- Phone Number: (+33)156095625
- Email: pascal.houillier@aphp.fr
-
Principal Investigator:
- Jean-Philippe Bertocchio, MD, PhD
-
Sub-Investigator:
- Pascal Houillier, MD, PhD
-
Sub-Investigator:
- Eric Thervet, MD, PhD
-
Sub-Investigator:
- Anne Blanchard, MD, PhD
-
Sub-Investigator:
- Philippine Davis, MD
-
Sub-Investigator:
- Gérard Maruani, MD
-
Paris, France
- Recruiting
- Clinic Paris Area
-
Contact:
- Aurélie Rousseau, MD
- Phone Number: 33177456764
- Email: aurelie.rousseau15@gmail.com
-
Sub-Investigator:
- Jean-Marie Garcin, MD
-
Sub-Investigator:
- Pascale Presberg, MD
-
Sub-Investigator:
- Bruno Donadille, MD
-
Sub-Investigator:
- Sylvie Roux-Guinot, MD
-
Sub-Investigator:
- Emmanuelle Lecornet-Sokol, MD
-
Paris, France
- Recruiting
- Cochin Hospital, APHP
-
Contact:
- Jérôme Bertherat, MD, PhD
- Phone Number: 33158411919
- Email: jerome.bertherat@aphp.fr
-
Sub-Investigator:
- Lionel Groussin, MD, PhD
-
Sub-Investigator:
- Léopoldine Bricaire, MD
-
Paris, France
- Recruiting
- Lariboisière Hospital, APHP
-
Contact:
- Jean-Pierre Riveline, MD
- Phone Number: 33149959072
- Email: jeanpierre.riveline@aphp.fr
-
Sub-Investigator:
- Martine Cohen-Solal, MD, PhD
-
Paris, France
- Recruiting
- Necker Hospital, AP-HP
-
Contact:
- Bertrannd Knebelmannn, MD, PhD
- Phone Number: 33 1 44 49 54 58
- Email: bertrand.knebelmann@aphp.fr
-
Sub-Investigator:
- Christophe Legendre, MD, PhD
-
Paris, France
- Recruiting
- Pitié-Salpêtrière Hospital, APHP
-
Contact:
- Anne Bachelot, MD, PhD
- Phone Number: 33142177832
- Email: anne.bachelot@aphp.fr
-
Sub-Investigator:
- Cécile Ghander, MD
-
Sub-Investigator:
- Geoffroy Desbuissons, MD
-
Sub-Investigator:
- Hassan Izzedine, MD, PhD
-
Sub-Investigator:
- Christel Jublanc, MD
-
Sub-Investigator:
- Isabelle Tostivint, MD
-
Paris, France
- Recruiting
- Tenon Hospital, APHP
-
Contact:
- Jean-Philippe Haymann, MD, PhD
- Phone Number: 33156016771
- Email: jean-philippe.haymann@aphp.fr
-
Sub-Investigator:
- Emmanuel Letavernier, MD, PhD
-
Poitiers, France
- Recruiting
- Clinic Poitiers Area
-
Contact:
- Pierre Nocent, MD
- Phone Number: 33549379404
- Email: pnocent@gmail.com
-
Quimper, France
- Recruiting
- Laennec Hospital
-
Contact:
- Tiphaine Roger, MD
- Phone Number: 33298526076
- Email: t.guyon-roger@ch-cornouaille.fr
-
Reims, France
- Recruiting
- Reims University Hospital
-
Contact:
- Sang Ly, MD
- Phone Number: 33326787878
- Email: tly@chu-reims.fr
-
Sub-Investigator:
- Antoine Braconnier, MD, MSc
-
Rennes, France
- Recruiting
- Clinic Rennes Area
-
Contact:
- Denis Pinsard, MD
- Phone Number: 33223300130
- Email: depinsard@orange.fr
-
Rouen, France
- Recruiting
- Charles Nicolle Hospital
-
Contact:
- Ferielle Louillet, MD
- Phone Number: 33232888990
- Email: ferielle.louillet@chu-rouen.fr
-
Saint-Junien, France, 87200
- Recruiting
- Clinic Area
-
Contact:
- Severine Boqueho, MD
- Phone Number: +335 44 00 09 38
- Email: severineboqueho@orange.fr
-
Saint-Ouen, France
- Recruiting
- Clinique du Landy
-
Contact:
- Laurence Nicolet, MD
- Phone Number: 33149458005
- Email: laurence.nicolet@fsef.net
-
Strasbourg, France
- Recruiting
- Hautepierre Hospital
-
Contact:
- Rose-Marie Javier, MD
- Phone Number: 33388116788
- Email: rose-marie.javier@chru-strasbourg.fr
-
Toulon, France
- Recruiting
- Sainte Anne Hospital, HIA
-
Contact:
- Julie Beaume, MD
- Phone Number: 33483162340
- Email: julie.beaume@gmail.com
-
Toulouse, France
- Recruiting
- Larrey Hospital
-
Contact:
- Delphine Vezzosi, MD, PhD
- Phone Number: 33567771701
- Email: vezzosi.d@chu-toulouse.fr
-
Tourcoing, France
- Recruiting
- Guy Chatiliez Hospital
-
Contact:
- Anne-Sophie Balavoine, MD
- Phone Number: 33320694949
- Email: asbalavoine@ch-tourcoing.fr
-
Tours, France
- Recruiting
- Bretonneau Hospital
-
Contact:
- Peggy Pierre, MD
- Phone Number: 33247479816
- Email: pierre@med.univ-tours.fr
-
Sub-Investigator:
- Lise Crinière, MD
-
Sub-Investigator:
- Elise Pinto Da Rocha, MD
-
Valenciennes, France
- Recruiting
- Valenciennes Hospital
-
Contact:
- Miriam Ladsous, MD
- Phone Number: 33327143333
- Email: ladsous-m@ch-valenciennes.fr
-
Sub-Investigator:
- Marc Ulrich, MD
-
Sub-Investigator:
- Aniela Stroea, MD
-
Villeneuve-Saint-Georges, France
- Recruiting
- CHIV - Lucie et Raymond Aubrac
-
Contact:
- Anne-Marie Oudrer, MD
- Phone Number: 33143862000
- Email: anne-marie.marteil-oudrer@chiv.fr
-
-
La Réunion
-
Saint-Denis, La Réunion, France
- Recruiting
- Felix Guyon Hospital
-
Contact:
- Xavier Debussche, MD
- Phone Number: 33262905610
- Email: xavier.debussche@chu-reunion.fr
-
Sub-Investigator:
- Arabelle Fioconni, MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
All patients for whom hypoparathyroidism is diagnosed in France
Description
Inclusion Criteria:
- patient fro whom chronic hypoparathyroidism is diagnosed
- patient living in France
Exclusion Criteria:
- patient who does not want his data to be collected in this registry
- pseudo-hypoparathyroidism
- acute hypoparathyroidism
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Hypoparathyroidism
No intervention.
|
No intervention
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assessment of the epidemiology of patients with hypoparathyroidism in France
Time Frame: Through study completion, about 2 years
|
Data collected by questionnaire about etiology of hypoparathyroidism, filled by physicians from clinic folders
|
Through study completion, about 2 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assessment of the biology at inclusion will describe the evolution of the included population from diagnosis to now (inclusion)
Time Frame: At inclusion (under treatment): through study completion, about 2 years
|
Number of patients with at least one anomaly at biology (calcemia in mM, calciuria in mmol/j, parathormone in pg/ml, creatininemia in µM, phosphatemia in mM, vitamin D in nmol/l & magnesemia in mM) at inclusion
|
At inclusion (under treatment): through study completion, about 2 years
|
Assessment of the management at inclusion will describe treatment and complications at inclusion
Time Frame: At inclusion (under treatment): through study completion, about 2 years
|
Number of patients with clinical outcomes (complications such as cataract, nephrolithiasis, nephrocalcinosis, and others) and their management at inclusion
|
At inclusion (under treatment): through study completion, about 2 years
|
Assessment of the biology (calcemia, calciuria, parathormone, creatininemia, phosphatemia & magnesemia) at diagnosis and drug therapy at inclusion will describe population
Time Frame: Through study completion, about 2 years
|
Number of patients with at least one anomaly at biology (calcemia in mM, calciuria in mmol/j, parathormone in pg/ml, creatininemia in µM, phosphatemia in mM, vitamin D in nmol/l & magnesemia in mM) at diagnosis
|
Through study completion, about 2 years
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Assessment of the physician's management will help describing the habits of french physician who manage hypoparathyroidism in terms of follow-up
Time Frame: At inclusion
|
Data on habits of included physicians about their management of patients with hypoparathyroidism: frequency of complications' follow-up (nephrocalcinosis, cataract, nephrolithiasis and other calcifications) in terms of radiology (CT-scan, echotomography, radiography) and biology (calcium in mM, phosphate in mM, parathormone in pg/ml, magnesium in mM, vitamin D in nmol/l and creatininemia in µM).
|
At inclusion
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Jean-Philippe Bertocchio, MD, PhD, European Georges Pompidou Hospital, APHP
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
July 1, 2016
Primary Completion (Estimated)
September 1, 2030
Study Completion (Estimated)
September 1, 2031
Study Registration Dates
First Submitted
July 9, 2016
First Submitted That Met QC Criteria
July 17, 2016
First Posted (Estimated)
July 20, 2016
Study Record Updates
Last Update Posted (Actual)
September 8, 2023
Last Update Submitted That Met QC Criteria
September 7, 2023
Last Verified
September 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- EpiHypo
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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