- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02902263
Inter-Hospital Transfer to a Vascular Neurology Unit After Telethrombolysis (TRATT)
Inter-Hospital Transfer to a Vascular Neurology Unit After Telethrombolysis in France Comté
Early thrombolysis is essential in treating ischemic strokes. The time window for thrombolysis is limited to 4,5 hours after symptoms onset.
In the French region of Franche Comté, in order to reduce the thrombolytic delay, a telemedicine network was developed between the neurovascular reference unit (NVU) localised in the University Hospital of Besançon and the peripheral hospital centres. Patients may then be transported to the NVU immediately after the thrombolysis initiation.
The aim of our study was to assess the relevance of a systematic medicalization of transfer to the NVU of patients with stroke who were telethrombolyzed before.
It was a retrospective, monocentric and observational study conducted over 24 months, in Franche-Comte (France).
Study Overview
Status
Conditions
Detailed Description
Stroke is a major health problem with increasing incidence. It represents the leading cause of disability and the third cause of death in France. There are two main types of stroke: ischemic (80%) or hemorrhagic (20%).
Early thrombolysis is essential in treating ischemic strokes. The time window for thrombolysis is limited to 4,5 hours after symptoms onset.
In the French region of Franche Comté, in order to reduce the thrombolytic delay, a telemedicine network was developed between the neurovascular reference unit (NVU) localised in the University Hospital of Besançon and the peripheral hospital centres. Patients may then be transported to the NVU immediately after the thrombolysis initiation.
The aim of our study was to assess the relevance of a systematic medicalization of transfer to the NVU of patients with stroke who were telethrombolyzed before.
It was a retrospective, monocentric and observational study conducted over 24 months, in Franche-Comte (France). Evaluation of neurological status was made with the Glasgow score (GCS) and National Institute of Health Stroke Score (NIHSS). The respiratory (SpO2; needs O2) and hemodynamic status (arterial blood pressure, heart rate) were assessed as well as the need for medical resuscitation at different times of the transport (thrombolysis, transfer, arrival at the Regional University Hospital Centre).
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Besançon, France, 25030
- CHRU Besançon
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Consecutive patients admitted in one emergency departments of four peripheral hospital centres in Franche Comté (Pontarlier, Vesoul, Gray and Dôle).
Patients admitted for ischemic stroke, treated by thrombolysis and transferred to tue NVU
Description
Inclusion Criteria:
- Patient with ischaemic stroke
- Emergency department admission between 01/01/2012 and 12/31/2013
- Telemedicine stroke consult
- Thrombolysis therapy
- Patient transfered to NVU after thrombolysis initiation
- Transfer staffed by a qualified physician
Exclusion Criteria:
- Transfer non staffed by a qualified physician
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Only
- Time Perspectives: Retrospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Patient neurological status assessed by NIHSS score during transfer to NVU
Time Frame: one day
|
one day
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Patient neurological status assessed by Glasgow score during transfer to NVU
Time Frame: one day
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one day
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Patient respiratory status assessed by oxygen saturation
Time Frame: one day
|
one day
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Patient hemodynamic status assessed by systolic and diastolic pressure
Time Frame: one day
|
one day
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Nenert E, Pretalli JB, Bouamra B, Puyraveau M, Fehner L, Labourey JM, Desmettre T. Transfert interhospitalier vers une unité de neurologie vasculaire des accidents vasculaires cérébraux ischémiques téléthrombolysés : pertinence d'une médicalisation systématique ? Ann. Fr. Med. Urgence (2016).
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- P/2015/248
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
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