co2 Gap and co2/o2 Ratio in Liver Transplant Patients (co2gap)

Use of the Venoarterial Carbon Dioxide Gap and Arteriovenous Oxygen Content to Guide the Resuscitation in the Liver Transplant Patients

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Study Overview

• Status: Unknown
• Conditions: Liver Transplantation
• Intervention / Treatment: Diagnostic test: Fluid challenge

Detailed Description

use of carbon dioxide gap and arterio venous oxygen content to trace the effect of preload challenge by giving via a specific venous line , first 150 ml is infused over one minute, after stroke volume at one minute measure the remaining 350 ml is infused over 14 minutes at constant rate , the fluid challenge performed with albumin 5% , fluid responsiveness is an increase in stroke volume by 15% after infusion of 500ml albumin 5%.

Objectives is to investigate the ability of VA-co2 gap and gap/ ratio to predict the hemodynamic response to mini fluid challenge, and to compare the validity of VA-co2 gap and gap/ratio with svo2 for prediction of fluid responsiveness.

• Study Type: Interventional
• Enrollment (Anticipated): 40
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Ahmed m Mukhtar, Professor; Phone Number: +0220111420844; Email: Ahmed.mukhtar@kasralainy.edu.eg
• Study Contact Backup: Name: Hassan kh Nagi, Professor; Phone Number: 01223634792; Email: hknagi@hotmail.com

Study Locations

• Egypt
  • Cairo, Egypt, 11511
    • Recruiting
    • Cairo university medical school
    • Contact: Ahmed m Mukhtar, professor; Phone Number: 002 01114208444; Email: ahmed.mukhtar@kasralainy.edu.eg
    • Contact: Hassan kh Nagy, professor; Phone Number: 002 01223634792; Email: hknagi@hotmail.com
  • Cairo, Egypt, 11562
    • Recruiting
    • Kasralainy Hospital
    • Contact: Ahmed Mukhtar, Professor; Phone Number: 01114208444; Email: Ahmed.mukhtar@kasralainy.edu.eg
    • Contact: Hassan Khaled, Professor; Phone Number: 01223634792; Email: hknagi@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• patients post liver transplantation
• serum lactate >2mmol/L

Exclusion Criteria:

• age less than 18 years
• patients with fulminant liver failure.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CO2 gap; The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.	Diagnostic test: Fluid challenge; Fluid challenge and measure change in co2 gap

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
co2gap	Difference between arterial and venous co2 gap	30 minuets after fluid bolus

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Stroke volume	Stroke volume assessed by cardiometry	Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus

Collaborators and Investigators

• Sponsor: Kasr El Aini Hospital
• Investigators: Principal Investigator: Ahmed m Mukhtar, professor, kasrelainy medical school,cairo university,cairo,egypt; Study Chair: Hassan kh Nagi, professor, kasrelainy medical school,cairo university,cairo,egypt

Study record dates

Study Major Dates

• Study Start (Actual): June 12, 2017
• Primary Completion (Anticipated): May 12, 2018
• Study Completion (Anticipated): September 12, 2018

Study Registration Dates

• First Submitted: December 11, 2017
• First Submitted That Met QC Criteria: December 14, 2017
• First Posted (Actual): December 15, 2017

Study Record Updates

• Last Update Posted (Actual): March 29, 2018
• Last Update Submitted That Met QC Criteria: March 27, 2018
• Last Verified: March 1, 2018

More Information

Terms related to this study

• Other Study ID Numbers: N-60-2017

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No