- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03391349
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Chronic Periodontitis and Diabetic Subjects
Quantification of Proteomes: L-plastin , Lipocalin and Adiponectin in Subgingival Tissue Samples of Generalized Severe Chronic Periodontitis Patients With and Without Type II Diabetes Mellitus
Study Overview
Status
Conditions
Detailed Description
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients willing to participate in the study.
- Male patients within the age group 35 to 60 years.
- Patients having ≥ 10 natural teeth.
- No history of long term antibiotic use in the past 6 months and no history of diabetes mellitus.
For Group I:
• Generalized severe chronic periodontitis subjects (30% or more sites with clinical attachment loss (CAL) ≥ 5mm) without type II diabetes mellitus.
For Group II:
• Generalized severe chronic periodontitis subjects (30% or more sites with clinical attachment loss (CAL) ≥ 5mm) diagnosed with type II diabetes mellitus (HbA1C levels ≥7%) for the past 5 years and is under oral medication.
Exclusion Criteria:
- Patients with systemic conditions, such as cardiovascular and respiratory diseases, HIV infection, immunosuppressive patients and patients under chemotherapy.
- Smokers and other behavioral factors which may influence the study.
- Patients who had undergone periodontal therapy within the previous 6 months.
Female patients (due to hormonal changes and pregnancy which may alter the oral flora).
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Study Plan
How is the study designed?
Design Details
- Observational Models: Other
- Time Perspectives: Other
Cohorts and Interventions
Group / Cohort |
---|
Group I
GROUP I: 35 generalized severe chronic periodontitis subjects without type II diabetes mellitus and systemically healthy.
|
Group II
GROUP II: 35 generalized severe chronic periodontitis subjects diagnosed with type II diabetes mellitus.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
mRNA expression of L-plastin,lipocalin and adiponection
Time Frame: 9 months
|
mRNA expression of L-plastin,lipocalin and adiponectin using Real Time PCR
|
9 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Quantify the levels of L-plastin, lipocalin and adiponectin
Time Frame: 9 months
|
Quantify levels of L-plastin, lipocalin and adiponectin using ELISA.
|
9 months
|
Collaborators and Investigators
Investigators
- Study Director: Jaideep Mahendra, MDS,PhD, Meenakshi Ammal Dental College
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MADC/IRB-IX/2016/151
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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