Comparison of Different EtCO2 Levels in Preventing Postoperative Nausea and Vomiting in Gynecological Patients Undergoing Laparoscopic Surgery

Comparison of Different EtCO2 Levels in Preventing Postoperative Nausea and Vomiting

Sponsors

Lead sponsor: Karadeniz Technical University

Source Karadeniz Technical University
Brief Summary

We aimed to evaluate the different ETCO2 levels (with the help of ultrasonographic optic nerve sheath diameter) in preventing gynecological laparoscopic surgeons' postoperative nausea induced by intracranial pressure change due to pneumoperitoneum and trandelenburg position.

Detailed Description

Although gynecologic laparoscopic surgery is a preferred technique in recent years due to its minimally invasive technique, the incidence of postoperative nausea and vomiting (PONV) is 53-72%. In such operations, intra-abdominal pressure due to trandelenburg position and carbondioxide insufflation causes intra-cranial venous obstruction and intra-cranial pressure increase. In addition, intra-cranial blood flow and ultimately intra-cranial pressure increase due to gravity and increased venous return resistance (peripheral vascular resistance). Intra-cranial CO2 concentration increase results in intra-cranial vascular dilatation, followed by ICP increase. High intracranial pressure may cause an increase in the incidence of PONV after gynecological laparoscopic surgery. Measurement of optic nerve sheath diameter with USG, a noninvasive method for detecting intracranial pressure increases, has been used frequently in intensive care units in recent years. we aimed to evaluate the different ETCO2 levels (during the operation with 10 minute intervals, and also with the help of ultrasonographic optic nerve sheath diameter) in preventing gynecological laparoscopic surgeons' postoperative nausea induced by intracranial pressure change due to pneumoperitoneum and trandelenburg position.

Overall Status Recruiting
Start Date January 22, 2018
Completion Date November 1, 2020
Primary Completion Date May 15, 2019
Study Type Observational
Primary Outcome
Measure Time Frame
EtCO2 During the operation (in 10 minutes interval)
Enrollment 60
Condition
Eligibility

Sampling method: Probability Sample

Criteria:

Inclusion Criteria:

25-50 age, ASA I / II, BMI: 18-33 kg/m2, operation time: 50-130 min., gynecological laparoscopy

Exclusion Criteria:

In previous operations, Patients with postoperative nausea-vomiting (PONV) history, Smoking, Vehicle stays, Liver and kidney dysfunction, Abnormal fluid electrolyte balance, Gastrointestinal system disease, Preoperative antiemetic drug use, Cerebral disease,dysrhythmia

Gender: Female

Minimum age: 25 Years

Maximum age: 50 Years

Healthy volunteers: No

Overall Official
Last Name Role Affiliation
Ahmet Besir, MD Study Chair Karadeniz Teknit Üniversitesi Tıp Fakültesi
Overall Contact

Last name: Ahmet Besir

Phone: +90 4623775398

Phone ext: 5398

Email: [email protected]

Location
facility status contact
Karadeniz Teknik Universitesi Recruiting Ahmet Besir, MD +90 4623775398 5398 [email protected]
Karadeniz Technical University, Dept Obs and Gyn / Anestesiology Not yet recruiting Ahmet Besir, MD +904623775396 [email protected]
Location Countries

Turkey

Verification Date

November 2019

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Karadeniz Technical University

Investigator full name: Ahmet Besir

Investigator title: Assistant professor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Arm group label: Group A

Description: ETCO2=26-35 mmHg

Arm group label: Group B

Description: ETCO2=36-45 mmHg

Study Design Info

Observational model: Case-Control

Time perspective: Prospective

Source: ClinicalTrials.gov