Anemia and Inflammation

Interactive Effects of Iron Status and Inflammation on Serum Hepcidin and Erythrocyte Iron Incorporation in Young Women

Sponsors

Lead Sponsor: Swiss Federal Institute of Technology

Collaborator: Ibn Tofail University-CNESTEN

Source Swiss Federal Institute of Technology
Brief Summary

During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain.

Overall Status Completed
Start Date September 15, 2017
Completion Date June 30, 2018
Primary Completion Date March 29, 2018
Study Type Observational
Primary Outcome
Measure Time Frame
Fractional and total iron absorption 14 days after the second baseline test meal administration
Fractional and total iron absorption 14 days after the test meal administered 24 hours after vaccination
Secondary Outcome
Measure Time Frame
Serum hepcidin up to 36 hours
Serum Interleukin 6 up to 36 hours
Serum ferritin up to 36 hours
Serum transferrin up to 36 hours
Serum CRP up to 36 hours
Serum AGP up to 36 hours
Enrollment 50
Condition
Intervention

Intervention Type: Biological

Intervention Name: Dultavax and Vaxigrip

Description: All the women got an influenza/DTP vaccine in order to induce acute inflammation

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- BMI <27.5kg/m2

- body weight <70kg

- either non-anemic (Hb>12.5g/dl) or anemic (Hb between 8-12 g/dl and ferritin <15ng/ml)

Exclusion Criteria:

- pregnant or lactating

- chronic disease

- smoking

- inflammation defined as CRP<5mg/L; AGP<1g/L

Gender: Female

Minimum Age: 18 Years

Maximum Age: 49 Years

Healthy Volunteers: Accepts Healthy Volunteers

Location
Facility: Ibn Tofail University-CNESTEN
Location Countries

Morocco

Verification Date

August 2018

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Swiss Federal Institute of Technology

Investigator Full Name: Prof. Michael B. Zimmermann

Investigator Title: Prof. Dr. med.

Has Expanded Access No
Condition Browse
Arm Group

Label: Non-anemic women

Label: anemic women

Description: anemia due to iron deficiency

Patient Data No
Study Design Info

Observational Model: Case-Only

Time Perspective: Prospective

Source: ClinicalTrials.gov