Anemia and Inflammation
Interactive Effects of Iron Status and Inflammation on Serum Hepcidin and Erythrocyte Iron Incorporation in Young Women
| Sponsors |
Lead Sponsor: Swiss Federal Institute of Technology Collaborator: Ibn Tofail University-CNESTEN |
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| Source | Swiss Federal Institute of Technology | ||||||||||||||
| Brief Summary | During inflammation hepcidin concentrations are increased, leading to a decrease in iron absorption. In iron deficiency anemia hepcidin is suppressed due to the activation of erythropoiesis. Whether inflammation or anemia has the stronger effect on hepcidin is uncertain. |
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| Overall Status | Completed | ||||||||||||||
| Start Date | September 15, 2017 | ||||||||||||||
| Completion Date | June 30, 2018 | ||||||||||||||
| Primary Completion Date | March 29, 2018 | ||||||||||||||
| Study Type | Observational | ||||||||||||||
| Primary Outcome |
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| Secondary Outcome |
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| Enrollment | 50 | ||||||||||||||
| Condition | |||||||||||||||
| Intervention |
Intervention Type: Biological Intervention Name: Dultavax and Vaxigrip Description: All the women got an influenza/DTP vaccine in order to induce acute inflammation |
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| Eligibility |
Sampling Method: Non-Probability Sample
Criteria:
Inclusion Criteria: - BMI <27.5kg/m2 - body weight <70kg - either non-anemic (Hb>12.5g/dl) or anemic (Hb between 8-12 g/dl and ferritin <15ng/ml) Exclusion Criteria: - pregnant or lactating - chronic disease - smoking - inflammation defined as CRP<5mg/L; AGP<1g/L Gender: Female Minimum Age: 18 Years Maximum Age: 49 Years Healthy Volunteers: Accepts Healthy Volunteers |
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| Location |
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| Location Countries |
Morocco |
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| Verification Date |
August 2018 |
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| Responsible Party |
Type: Principal Investigator Investigator Affiliation: Swiss Federal Institute of Technology Investigator Full Name: Prof. Michael B. Zimmermann Investigator Title: Prof. Dr. med. |
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| Has Expanded Access | No | ||||||||||||||
| Condition Browse | |||||||||||||||
| Arm Group |
Label: Non-anemic women Label: anemic women Description: anemia due to iron deficiency |
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| Patient Data | No | ||||||||||||||
| Study Design Info |
Observational Model: Case-Only Time Perspective: Prospective |
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