- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03871140
Utility of Ultrasound Imaging for Diagnosis of Focal Liver Lesions: A Radiomics Analysis
March 11, 2019 updated by: Ping Liang, Chinese PLA General Hospital
Intelligent Diagnosis of Focal Liver Lesions and Thermal Ablation Zone of Liver Cancer Based on Ultrasound Imaging
Ultrasound (US) as first-line imaging technology in detecting focal liver lesions,also plays a crucial role in evaluating image and guiding ablation which is the main treatment for liver lesions.
However, the effect of US in diagnosing liver lesions is challenged by several factors including being highly dependent on doctor's experience, low signal-to-noise ratio, low resolution for lesion feature,large error from thermal field evaluation during the process of ablation and so on.
Therefore, it is of great significance to construct an intelligent US analysis system depending on the digital information technology.
Basing on these problems,the following research will be involved in our project: 1) US database of liver lesions with seamless connection to Picture Archiving and Communication Systems (PACS) will be developed, with the aim to provide standard data for intelligent US analysis.
2) Deep learning model for accurate segmentation, detection and classification of liver lesions on US images will be studied.
Then automatic extraction, selection and analysis of liver lesion ultrasound features and the intelligent US diagnosis for liver lesions will be realized.
3) Proposing a clustering model with deep image features, and depicting the similarity measurement of liver cancer, which can be furthered used to link the liver cancer feature to optimal ablation parameters.
The intelligent decision-making system for quantifying thermal ablation will be established.
4) Regression algorithm and Generative Adversarial Nets will be developed to extract the image features of liver cancer which will predict risk factors after US-guided thermal ablation.Based on the above researches, it is of great value to establish an intelligent focal liver lesion US diagnosis system involving intelligent diagnosis,personalized ablation strategy and accurate prognosis evaluation, improving the level of accurate diagnosis and treatment of liver lesions.
Study Overview
Status
Unknown
Intervention / Treatment
Study Type
Observational
Enrollment (Anticipated)
10000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Jie Yu, Dr
- Phone Number: 15901417963
- Email: jiemi301@163.com
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100853
- Recruiting
- Chinese PLA General Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
patients with focal liver lesions
Description
Inclusion Criteria:
- clear ultrasound imaging of focal liver lesions including malignant liver tumors such as hepatocellular carcinoma, metastatic liver cancer and benigh liver tumors such as hemangioma and focal nodular hyperplasia and so on can be acquired.
- clear ultrasound imaging of liver tissues backgroud without lesions can be acquired.
- disease history and pathological diagnosis of the lesions can be acquired.
Exclusion Criteria:
- patients unsuitable for ultrasound san
- patients counldn't provide disease history such as hepatitis, alcohol intake and so on
- patients without pathological results
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
sensitivity
Time Frame: through study completion, an average of 3 year
|
diagnosis sensitivity of intelligent ultrasound analysis
|
through study completion, an average of 3 year
|
AUC value
Time Frame: through study completion, an average of 3 year
|
Area under the receiver operating characteristic (ROC) curve (AUC)
|
through study completion, an average of 3 year
|
specificity
Time Frame: through study completion, an average of 3 year
|
diagnosis specificity of intelligent ultrasound analysis
|
through study completion, an average of 3 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2017
Primary Completion (Anticipated)
December 30, 2020
Study Completion (Anticipated)
December 30, 2021
Study Registration Dates
First Submitted
April 29, 2018
First Submitted That Met QC Criteria
March 11, 2019
First Posted (Actual)
March 12, 2019
Study Record Updates
Last Update Posted (Actual)
March 12, 2019
Last Update Submitted That Met QC Criteria
March 11, 2019
Last Verified
April 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 301jrcsk3
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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