- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04064528
Effects of Age on Amino Acid Delivery to Tendon
December 13, 2023 updated by: Chad C. Carroll, Purdue University
Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis.
While most published research has been completed in animal models, research with young adults has shown that a leucine-rich whey isolate consumed during a chronic resistance training (RT) intervention resulted in greater gains (~60%) in tendon CSA when compared to placebo.
Leucine-rich diets have also improved tendon collagen content in rodents.
Further, in our preliminary work utilizing microdialysis, we demonstrate that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids to tendons in young adults (21-30 years).
However, whether aging alters the delivery of amino acids to tendons after oral consumption has not be investigated.
In order to optimize amino acid dosing for chronic interventional studies, we wish to determine if aging influences amino acid concentration in the peritendinous (space around the tendon) space after oral consumption.
Study Overview
Study Type
Interventional
Enrollment (Actual)
20
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Indiana
-
West Lafayette, Indiana, United States, 47907
- Purdue University
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
21 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
-
Exclusion Criteria:
- body mass index >35 kg•m-2, those on medications known to affect protein or collagen metabolism, e.g. acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors, previous history of tendinopathy, or diabetes.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Non-Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Young
Young adults will be given a 10 g oral bolus of amino acids.
|
10 g bolus of essential amino acids
|
Experimental: Older Adults
Older adults will be given a 10 g oral bolus of amino acids.
|
10 g bolus of essential amino acids
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Achilles Peritendinous Amino Acid Levels in young and older adults
Time Frame: 0-6 hours post consumption
|
Concentrations of amino acids will be measured from around the Achilles tendon
|
0-6 hours post consumption
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Chad C Carroll, PhD, Purdue University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 6, 2019
Primary Completion (Actual)
August 1, 2022
Study Completion (Actual)
August 1, 2023
Study Registration Dates
First Submitted
August 20, 2019
First Submitted That Met QC Criteria
August 20, 2019
First Posted (Actual)
August 22, 2019
Study Record Updates
Last Update Posted (Actual)
December 14, 2023
Last Update Submitted That Met QC Criteria
December 13, 2023
Last Verified
December 1, 2023
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 1904022075
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Aging
-
Tuba MadenCompletedAging | Aging Problems | Aging Disorder
-
Radboud University Medical CenterNot yet recruitingAging | Aging Well | Immuno Aging
-
University of Santiago de CompostelaEuropean Regional Development Fund; Center for Industrial Technological Development...Completed
-
TruDiagnosticBlushield USANot yet recruitingAging | Aging Well
-
San Diego State UniversityCompleted
-
Lithuanian Sports UniversityCompletedAging | Healthy AgingLithuania
-
Amazentis SAproDERM GmbHCompleted
-
University of West AtticaNot yet recruiting
-
University of Santiago de CompostelaAgencia Estatal de Investigación, SpainRecruiting
-
Beijing HospitalBGI-ShenzhenCompletedAging | Healthy Aging
Clinical Trials on Amino Acids
-
Texas A&M UniversityRecruiting
-
University of TorontoCompletedHealthy | Increased Metabolic Requirement
-
Assistance Publique - Hôpitaux de ParisKyowa Hakko Kogyo (Japan) providing the amino acidsCompletedElderly | MetabolismFrance
-
The Hospital for Sick ChildrenCanadian Institutes of Health Research (CIHR)Completed
-
University of British ColumbiaUnknown
-
Baylor College of MedicineNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)CompletedKwashiorkor | Marasmus | Protein-energy MalnutritionJamaica
-
Montana State UniversityM.J. Murdoch Charitable Trust; Kreighbaum EndowmentCompleted
-
Hospital Universitari Vall d'Hebron Research InstituteCompletedHepatic EncephalopathySpain
-
McGill University Health Centre/Research Institute...CompletedPostoperative Protein CatabolismCanada
-
Chang Gung Memorial HospitalHanben EnterpriseUnknown