Computed Tomography Evaluation of Urinary Stones Densities Compared to in Vitro Analysis of Its Chemical Composition

Computed Tomography Evaluation of Urinary Stones Densities Compared to in Vitro Analysis of Its Chemical Composition


Lead sponsor: Assiut University

Source Assiut University
Brief Summary

The ability to predict stone composition, which influences patient treatment, depends on the accurate measurement of CT attenuation of stones. We will study the effects of stone composition, stone size, and scan collimation width on the measurement of attenuation in vitro.

Detailed Description

Recently, the use of noncontrast spiral computerized tomography (NCCT) has gained widespread acceptance in the evaluation of urinary stone patients. It has long been used clinically to evaluate the causes of radiolucent filling defects using Hounsfield units (HU) to distinguish calculi from tumor or blood clots, and to identify nonurologic causes of flank pain (Smith R etal ). Urinary stones have a significantly higher CT attenuation than the surrounding soft tissues and are virtually always visible on NCCT. Knowing the composition of a urinary calculus is frequently a key factor in determining its most appropriate management. Should the urine be alkalinized? Will the stone be amenable to extracorporeal shock wave lithotripsy (ESWL), or should ureteroscopy or percutaneous lithotripsy be attempted? Different techniques have been used to assist in determining the correct chemical composition of calculi. Urine pH, urinary crystals, prior stone history and the presence of urea-splitting organisms (Ramakumar S,etal). Several in vitro studies have suggested that NCCT can demonstrate measured differences in radiodensity among different urinary stones (Mitchenson HD etal,).With these clinical problems in mind, we sought to determine whether the composition of urinary calculi could be predicted by their CT characteristics in an attempt to find out the best technique for distinguishing the various stones compositions, provided that it is clinically practical and would not require repeated imaging of the patients.

Overall Status Not yet recruiting
Start Date March 30, 2020
Completion Date October 30, 2022
Primary Completion Date September 1, 2022
Study Type Observational
Primary Outcome
Measure Time Frame
comparison of CT densities of urinary stones with its chemical composition Baseline
Enrollment 100

Sampling method: Non-Probability Sample


Inclusion Criteria:

- Any Age will be included .

- Patient with suspected or known urinary stone disease.

- Eligible for doing NCCT.

- Giving written consent to participate

Exclusion Criteria:

- Patient with classical NCCT contraindication like morbid obesity and pregnancy .

- Patients with urinary stones will be treated by ESWL

- Refusal participation .

Gender: All

Minimum age: N/A

Maximum age: N/A

Overall Contact

Last name: Somia Usama, Master

Phone: 01060101215

Email: [email protected]

Verification Date

February 2020

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Assiut University

Investigator full name: Somia Usama Mohamed Rabea

Investigator title: Resident doctor

Has Expanded Access No
Condition Browse
Study Design Info

Observational model: Case-Only

Time perspective: Prospective