Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients

Acute Kidney Injury in Major Abdominal Surgery: Retrospective Study of 501 Patients

Sponsors

Lead Sponsor: Uppsala University

Source Uppsala University
Brief Summary

Retrospective study that aims to examine the presence of acute kidney injury (AKI) during major abdominal surgery, non- cardiac surgery. Using clinical and biochemical data in order to establish AKI frequency and risk factors.

Detailed Description

Ethical approval was submitted and approved by the regional ethical committee, Etisk prövningsnämnd Uppsala, # 2017/418.

Patients were selected from the time span of april 2016 to september 2017. The investigators identified 499 patients that had undergone any of the selected procedures. The procedures were, pancreatic resection, HIPEC surgery in colorectal setting, gynecological debulking in metastasized ovarian cancer, and liver resection.

The risk of acute kidney injury (AKI) by the KDIGO definition during the postoperative period will be estimated in the group as a whole, and for each type of surgery separately. In addition the data will be stratified by sex to investigate systematic gender disparities or physiological differences. Length of stay, thirty day and sixty day mortality will secondary endpoints.

Overall Status Completed
Start Date April 1, 2016
Completion Date September 30, 2017
Primary Completion Date September 30, 2017
Study Type Observational
Primary Outcome
Measure Time Frame
Incidence of AKI the first 24- 72 hours postop
Secondary Outcome
Measure Time Frame
Mortality 30, 60 and 360 days postoperatively
Major Adverse Kidney Events 30, 60 and 360 days postoperatively
Fluid balance 24-72h
Electrolyte disturbances 24-72h
Enrollment 499
Condition
Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

Any of the selected procedures.

Exclusion Criteria:

Patient has expressed his or her will to nor participate in any study.

Gender: All

Minimum Age: N/A

Maximum Age: N/A

Verification Date

October 2019

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Uppsala University

Investigator Full Name: Michael Hultström

Investigator Title: Associate professor

Has Expanded Access No
Condition Browse
Arm Group

Label: Pancreatic resection

Label: Liver resection

Label: HIPEC surgery

Label: Gynecological debulking surgery

Patient Data No
Study Design Info

Observational Model: Case-Only

Time Perspective: Retrospective

Source: ClinicalTrials.gov