Implementation and Effectiveness of Multidiscipline-Integrated Addiction Treatment Model

Management of substance use disorders in clinical settings is challenging. Approaches with integrated bio-psycho-social interventions, along with the engagement of families and self-help groups are strongly recommended. The Matrix intensive outpatient program has been developed in UCLA to help the psychostimulant misusers in the Southern California in 1980's. With integration of the existing evidence of addiction researches and empirically supported cognitive-behavior treatment techniques, the Matrix model developed manuals to address knowledge and skills needed for drug users in their early recovery and relapse prevention. The treatment was delivered in a 16-week intensive structured group sessions. There was also a 12-week educational sessions for the in-treatment individuals and their families. A substantial body of evidence has demonstrated the successful experience of the Matrix treatment model in management a broad spectrum of addictive disorders in many countries.

The objectives of the pilot project are to set up a multi-center collaborative clinical network with implementation of an integrated addiction treatment program modified from the UCLA Matrix model. Via the establishment of standardized subject recruitment criteria, treatment and outcome assessment procedures, the study aims to assess the adherence of participating clinical organizations to the study protocol, the acceptance of participating MA misusers for the integrated treatment program as well as the outcomes and their determinants for the treatment models.

Study Overview

• Status: Unknown
• Conditions: Amphetamine-Related Disorders
• Intervention / Treatment: Behavioral: cognitive-behavior group therapy; Behavioral: Individual supportive psychotherapy

Detailed Description

Methamphetamine (MA) use disorder is a serious legal and health problem worldwide. Reports from Ministry of Justice in Taiwan revealed that the MA-related crimes has tremendously increased over the past decade. The arrested users of scheduled II drugs, MA mainly, has surged from 34,886 in 2014 to 54,190 in 2016 in Taiwan. It is critical to tackle the emerging problems in Taiwan.

Management of MA use disorder in clinical settings is challenging. Approaches with integrated bio-psycho-social interventions, along with the engagement of families and self-help groups are strongly recommended. The Matrix intensive outpatient program has been developed in UCLA to help the psychostimulant misusers in the Southern California in 1980's.With integration of the existing evidence of addiction researches and empirically supported cognitive-behavior treatment techniques, the Matrix model developed manuals to address knowledge and skills needed for drug users in their early recovery and relapse prevention. The treatment was delivered in a 16-week intensive structured group sessions. There was also a 12-week educational sessions for the in-treatment individuals and their families. A substantial body of evidence has demonstrated the successful experience of the Matrix treatment model in management a broad spectrum of addictive disorders in many countries.

The objectives of the pilot project are to set up a multi-center collaborative clinical network with implementation of an integrated addiction treatment program modified from the UCLA Matrix model. Via the establishment of standardized subject recruitment criteria, treatment and outcome assessment procedures, the study aims to assess the adherence of participating clinical organizations to the study protocol, the acceptance of participating MA misusers for the integrated treatment program as well as the outcomes and their determinants for the treatment models.

• Study Type: Interventional
• Enrollment (Anticipated): 48
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Sheng-Chang Wang, Doctor; Phone Number: 36703 +886-37-206-166; Email: scwang69@gmail.com

Study Locations

• Taiwan
  • Taipei, Taiwan, 10341
    • Recruiting
    • Taipei City Hospital
    • Contact: Sheng-Chang Wang

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Aged 20-65
• Current methamphetamine use disorder by DSM-5, moderate and above
• Willing and able to provide informed consents

Exclusion Criteria:

• Severe physical or psychiatric conditions requiring emergent treatment
• Currently involved in judicial or criminal conditions
• Plan to go abroad or relocate in the next 6 months

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Cognitive-behavior group therapy group	Behavioral: cognitive-behavior group therapy; cognitive-behavior group therapy Frequency: thrice a week Treatment duration: 16 week; Behavioral: Individual supportive psychotherapy; Individual supportive psychotherapy 3 sessions during the 16-week treatment period

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Urine amphetamine test During Intervention	This test looks for amphetamine in urine once a week for 16 weeks.	16 weeks
Urine amphetamine test,Follow-Up	This test looks for amphetamine in urine once a month for 3 months.	3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The World Health Organization Quality of Life -BREF (WHOQOL-BREF) During Intervention	The content of the questionnaire is divided into four domains. The converted scores of each participant's answers are as low as 4 points and as high as 20 points in each category,a higher score means better quality of life.	16 weeks
The World Health Organization Quality of Life -BREF (WHOQOL-BREF),Follow-Up	The content of the questionnaire is divided into four domains. The converted scores of each participant's answers are as low as 4 points and as high as 20 points in each category,a higher score means better quality of life.	3 months

Collaborators and Investigators

• Sponsor: National Health Research Institutes, Taiwan

Study record dates

Study Major Dates

• Study Start (Actual): February 24, 2020
• Primary Completion (Anticipated): July 2, 2020
• Study Completion (Anticipated): December 15, 2020

Study Registration Dates

• First Submitted: December 12, 2019
• First Submitted That Met QC Criteria: December 16, 2019
• First Posted (Actual): December 18, 2019

Study Record Updates

• Last Update Posted (Actual): April 1, 2020
• Last Update Submitted That Met QC Criteria: March 30, 2020
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Keywords: Methamphetamine; Cognitive behavior group therapy
• Additional Relevant MeSH Terms: Mental Disorders; Chemically-Induced Disorders; Substance-Related Disorders; Amphetamine-Related Disorders
• Other Study ID Numbers: EC1080801

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No