- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04524637
The Utility of Thromboelastography in Traumatic Brain Injury
April 17, 2023 updated by: Hao Chen, MD, PhD, Shanghai 6th People's Hospital
The Utility of Thromboelastography for Predicting the Risk of Coagulation-Related Damages Secondary to Traumatic Brain Injury
Hemocoagulation disorder is recognized to have crucial effects on hemorrhagic or ischemic diseases.
Coagulation-related damages secondary to traumatic brain injury are common and severe secondary insults of head trauma and often leads to a poor prognosis.
In this study, we sought to assess if posttraumatic hemocoagulation disorders determined using thromboelastography are associated with coagulation-related damages secondary to traumatic brain injury, and evaluate their influence on outcome among patients with head trauma.
Based on above results, prediction models or risk scoring systems will be further developed and validated to predict coagulation-related damages secondary to traumatic brain injury.
Study Overview
Status
Recruiting
Conditions
Study Type
Observational
Enrollment (Anticipated)
500
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Hao Chen, M.D., Ph.D.
- Phone Number: 8405 86-21-64369181
- Email: chenhao_316@aliyun.com
Study Locations
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Shanghai, China, 200233
- Recruiting
- Shanghai Sixth People's Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Probability Sample
Study Population
Adult patients (18-80 years old) with isolated traumatic brain injury, who are admitted within 24 hours post-injury are included.
To avoid interfering factors, patients with existing prior neurological disease or known coagulation disorders, patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma or receiving blood components prior to blood draw, patients who deteriorate and die before determining whether coagulation-related damage exists are excluded.
Clinical data are documented, including age, gender, mechanisms of trauma, types of lesions as evidenced by imaging examination and laboratory examination, etc.
Description
Inclusion Criteria:
- Patients who are delivered to hospital within 24 hours after head trauma
- Patients whose abbreviated injury score (AIS) for other body regions is 3 or less are considered to be isolated traumatic brain injury
Exclusion Criteria:
- Patients with existing prior neurological disease
- Patients with known coagulation disorders
- Patients on anticoagulants and medications known to affect coagulation function within 30 days before trauma
- Patients receiving blood components prior to blood draw
- Patients who deteriorate and die before determining whether coagulation- related damage exists
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Traumatic brain injury
Patients who are delivered within 24 hours after head trauma and sustain isolated traumatic brain injury are included in this study.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Glasgow Outcome Scale scores
Time Frame: Six months
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Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery.
Unfavorable outcome is defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome is defined as a Glasgow Outcome Scale score of > 3.
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Six months
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Hao Chen, M.D., Ph.D., Shanghai 6th People's Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 1, 2018
Primary Completion (Anticipated)
December 31, 2024
Study Completion (Anticipated)
December 31, 2024
Study Registration Dates
First Submitted
August 20, 2020
First Submitted That Met QC Criteria
August 20, 2020
First Posted (Actual)
August 24, 2020
Study Record Updates
Last Update Posted (Actual)
April 18, 2023
Last Update Submitted That Met QC Criteria
April 17, 2023
Last Verified
April 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Cardiovascular Diseases
- Vascular Diseases
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Hematologic Diseases
- Hemorrhagic Disorders
- Craniocerebral Trauma
- Trauma, Nervous System
- Hemostatic Disorders
- Blood Coagulation Disorders
- Brain Injuries
- Wounds and Injuries
- Brain Injuries, Traumatic
Other Study ID Numbers
- 18PJD034
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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