Precision-Based Genomics in Prostate Cancer

A Multi-Center Natural History Study of Precision-Based Genomics in Prostate Cancer

Sponsors

Lead Sponsor: National Cancer Institute (NCI)

Source National Institutes of Health Clinical Center (CC)
Brief Summary

Background: Prostate cancer is the most common cancer and the second leading cause of death in males in the United States. Researchers want to find additional gene mutations that may increase a man s risk for prostate cancer and may affect how aggressive the disease is. Objective: To look at gene mutations in men with prostate cancer as well as the course of their disease to better understand how gene mutations relate to the way the cancer progresses and responds to treatment. Eligibility: Adult males 18 and older with prostate cancer who have at least one of the gene mutations researchers want to study and/or have been treated for their cancer and have had complete elimination of their cancer or stable disease for a long time. Design: Participants will be screened with a review of their medical records. Their gene test results will be reviewed, if available. They will be asked questions over the phone or in person. Participants do not need to visit the NIH for this study. But if they visit NIH for another study, their data and test results will be collected. They may give blood and urine samples. They may give leftover tumor samples. These samples will be used to study their genes. Participants who do not come to NIH on regular basis will be contacted every 6 months by phone or e-mail. They will be asked questions about their health. Data from their medical records will be collected. Participants will have testosterone and prostate-specific antigen (PSA) tests. Participants may be invited to NIH to give blood samples for research. Participants on this study will be followed for life....

Detailed Description

Background: - Prostate cancer is the most common cancer and the second leading cause of death in males in the United States with an estimated 191,930 new cases and 33,330 deaths in 2020. - There has been progress in identifying established risk factors for the development of prostate cancer, including genetic predisposition. The study of the molecular genetics of prostate cancer has identified pathogenic variants, such as BRCA1 and BRCA2 (associated with hereditary breast and ovarian cancer syndrome), HOXB13 (associated with hereditary prostate cancer), and DNA mismatch repair (MMR) gene variants (MLH1, MSH2, MSH6, PMS2, and EPCAM) associated with Lynch syndrome. - While our understanding of molecular genetics continues to grow, there remains a need to identify additional germline and somatic mutations and alterations that may increase an individual s risk to develop prostate cancer and potentially the aggressiveness of the disease. In studying the following alterations in prostate cancer, in both localized and advanced stages, potential expanded molecular findings may lead to actionable therapeutic targets and biomarker development. A better understanding of molecular genetics in a longitudinal study of subjects with prostate cancer may be helpful for the design of future treatment studies, and to develop a better understanding of the natural history of the disease Objectives: - To longitudinally evaluate subjects with prostate cancer with known germline and/or somatic variants in PIK3 and/or AKT, PALB2, BRIP1, RAD50, RAD51, RAD54, RB1, SPOP, Wnt/B-catenin pathway, and MMR genes: MLH1, MSH2, MSH6, PMS2, and EPCAM to better understand the natural history of the disease. - To longitudinally evaluate subjects with tumor mutational burden-high (TMB-H) prostate cancer [greater than or equal to 10 mutations/megabase (mut/Mb)]. Eligibility: - Subjects with histologically confirmed prostate cancer - Must have known germline and/or somatic variants in PIK3 and/or AKT, PALB2, BRIP1, RAD50, RAD51, RAD54, RB1, SPOP, Wnt/B-catenin pathway, and MMR genes: MLH1, MSH2, MSH6, PMS2, and EPCAM and/or TMB-high or be deemed an exceptional responder. NOTE: any platform for genomics testing is acceptable (research or CLIA-certified) - Age greater than or equal to 18 years old Design: - This will be a long-term multi-center study to comprehensively study participants with prostate cancer. - Participants will provide clinical information (including medical history, clinical tests, imaging studies and reports, surgical pathology reports, genetic test results). - Since long-term follow-up of individuals with prostate cancer is a major feature of the study, local sites intend to maintain active contact with study subjects for as long as possible. Participants will be followed throughout the course of their illnesses, with particular attention to patterns of disease recurrence and progression, response to therapies and duration of responses.

Overall Status Not yet recruiting
Start Date January 28, 2021
Completion Date June 30, 2027
Primary Completion Date June 30, 2026
Study Type Observational
Primary Outcome
Measure Time Frame
natural history of prostate cancer with known germline and/or somatic variants ongoing
natural history of TMB-H prostate cancer ongoing
Enrollment 2000
Condition
Eligibility

Sampling Method: Probability Sample

Criteria:

- INCLUSION CRITERIA: - Subjects with histologically confirmed prostate cancer. - Must have known germline and/or somatic variants in PIK3 and/or AKT, PALB2, BRIP1, RAD50, RAD51, RAD54, RB1, SPOP, Wnt/B-catenin pathway, and/or MMR genes: MLH1, MSH2, MSH6, PMS2, and EPCAM and/or TMB-high([defined as greater than or equal to 10 mutations/megabase (mut/Mb)]. NOTE: any platform for genomics testing is acceptable (research or CLIA-certified) OR - be deemed an exceptional responder. NOTE: an exceptional response is defined as achievement of either a) a complete response, or b) a confirmed partial response in a trial or treatment or a response of exceptionally long duration - Age greater than or equal to 18 years old. - Ability of subject to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: -None

Gender: Male

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
William L Dahut, M.D. Principal Investigator National Cancer Institute (NCI)
Overall Contact

Last Name: Katherine O Lee-Wisdom, R.N.

Phone: (240) 858-3525

Email: [email protected]

Location
Facility: Contact:
University of California San Diego | La Jolla, California, 92093, United States Rana McKay 858-657-7876 [email protected]
University of California at Los Angeles | Los Angeles, California, 90095, United States Matthew Rettig 310-794-7700 [email protected]
University of California San Francisco | San Francisco, California, 94143, United States Eric Small 415-353-7095 [email protected]
Lurie Cancer Center at Northwestern University | Chicago, Illinois, 60611, United States Maha Hussain 312-926-2413 [email protected]
National Institutes of Health Clinical Center | Bethesda, Maryland, 20892, United States For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 TTY8664111010 [email protected]
Massachusetts General Hospital, Cancer Center | Boston, Massachusetts, 02114, United States Xin Gao 617-724-4000 [email protected]
Dana Farber Cancer Institute | Boston, Massachusetts, 02215, United States Himisha Beltran 617-632-2429 [email protected]
University of Michigan | Ann Arbor, Michigan, 48109, United States Arul Chinnaiyan 734-647-8903 [email protected]
Mount Sinai Hospital | New York, New York, 10029, United States William Oh 212-241-6756 [email protected]
Memorial Sloan Kettering Cancer Center | New York, New York, 10065, United States Wassim Abida 646-422-4633 [email protected]
Weill Cornell Medicine | New York, New York, 10065, United States Cora Sternberg 646-962-2072 [email protected]
Oregon Health Sciences University | Portland, Oregon, 97239, United States Julie Graff 503-494-6594 [email protected]
University of Washington School of Medicine | Seattle, Washington, 98195, United States Bruce Montgomery 206-598-0860 [email protected]
Vall d'Hebron Institute of Oncology | Barcelona, 08035, Spain Joaquin Mateo (932) -54-3450 [email protected]
Location Countries

Spain

United States

Verification Date

January 11, 2021

Responsible Party

Type: Sponsor

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Cohort 1

Description: Subjects with histologically confirmed prostate cancer and genomic testing results

Label: Cohort 2

Description: Subjects with histologically confirmed prostate cancer who deemed to be an exceptional responder with or without genomic testing results

Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov