Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Sponsors

Lead Sponsor: Southeast University, China

Source Southeast University, China
Brief Summary

ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.

Overall Status Not yet recruiting
Start Date 2022-06-01
Completion Date 2022-12-30
Primary Completion Date 2022-12-30
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
the ratio of tidal volume in the BAL side and the other side up to 24 hours
Secondary Outcome
Measure Time Frame
partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio up to 24 hours
respiratory system compliance (the tidal volume to the driving pressure ratio) up to 24 hours
Enrollment 40
Condition
Intervention

Intervention Type: Other

Intervention Name: Recruitment Maneuver

Description: RM after BAL

Arm Group Label: RM after BAL

Eligibility

Criteria:

Inclusion Criteria: 1. Adult patients with invasive mechanical ventilation; 2. Patients who diagnosed with ARDS according to the Berlin definition 3. There are indications for bronchoalveolar lavage Exclusion Criteria: 1. Patients with contraindications for EIT procedures; 2. Patients with contraindications for RM; 3. Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD); 4. Pregnancy; 5. Refusal to sign informed consent

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

No

Overall Official
Last Name Role Affiliation
ling liu, phD Principal Investigator Zhongda Hospital Southeast University
Overall Contact Contact information is only displayed when the study is recruiting subjects.
Verification Date

2022-05-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Southeast University, China

Investigator Full Name: Ling Liu

Investigator Title: Director of Intensive Care Unit, Principal Investigator, Clinical Professor

Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: RM after BAL

Type: Experimental

Description: patients underwent RM after BAL

Label: Non-RM after BAL

Type: No Intervention

Description: patients did not undergo RM after BAL

Patient Data No
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Other

Masking: None (Open Label)

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