- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05629299
Pilot Study to Detect Monkey Pox Virus in Sperm: POXSPERM (POXSPERM)
November 28, 2022 updated by: University Hospital, Toulouse
Given the current emerging epidemic of the MonkeyPox Virus (MPXV) and its route of transmission, the main objective of this pilot study is to characterize the presence of the MPXV in the semen of patients in the acute phase of infection and following this infection.
Study Overview
Detailed Description
Since May 2022, a total of 16 000 new cases of Monkey Pox Virus infection has been reported in 76 non-endemic countries.
The WHO has declared this epidemic as a public health emergency.
Principal routes of transmission are direct skin or mucosa contact or aerosol transmission.
The current epidemic mainly affects men having sexual relations with others men and men reporting having recent sexual relations with new or multiple partners.
We may wonder if there is a risk of transmission during an intercourse.
Moreover, Monkey pox virus infection in human testicle has not been studied yet.
Among viruses that infect human semen, some viruses can persist for several months or even years in the semen of cured men.
In this context, we propose a research project about the pathophysiology of MPXV in the male genital tract by a clinical approach.
Men with a diagnosis of MPXV infection confirmed by a positive PCR and who agreed to be included as volunteer will go to CECOS at Paule de Viguier Hospital, Purpan.
Each patient will take a semen and urine sample, have a blood sample and a saliva sample, and a skin sample in case of a lesion; the earliest after the confirmation of the diagnosis of the infection (before the 7th day, the days will be noted) then on Day 15, Day 30, Day 60, Day 90 and Day 180.
Study Type
Interventional
Enrollment (Anticipated)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Manon CARLES, MD
- Phone Number: +33 05 67 77 10 07
- Email: carles.man@chu-toulouse.fr
Study Locations
-
-
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Toulouse, France
- CHU Toulouse
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Contact:
- Manon CARLES, MD
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 48 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- in the acute phase of MPXV infection and whose PCR reveals the viral genome in a skin sample or in any other sample.
- able to travel to the laboratory for the samples
- who gave his free and informed consent and having signed the consent
- Patient affiliated to a social security scheme or equivalent
Exclusion Criteria:
- Patient who has previously consulted for male infertility or who has previously performed an abnormal semen test (WHO standard)
- Patient with ejaculation disorder or unable to collect semen or with abnormal semen volume (<1.5 mL).
- Patient who presents serious clinical signs that do not allow him to travel to the investigation center.
- Patient under a protection regime (including guardianship, curatorship or safeguard of justice)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Monkey Pox infection
Men will give semen, saliva, skin, urine and blood specimens
|
Men will give semen, saliva, skin, urine and blood specimens
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
MPXV genomic DNA
Time Frame: Day 0
|
presence of MPXV DNA in the semen and others body fluids of infected patients in the acute phase and during the follow-up.
|
Day 0
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Manon CARLES, MD, University Hospital, Toulouse
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
November 1, 2022
Primary Completion (Anticipated)
November 1, 2024
Study Completion (Anticipated)
November 1, 2024
Study Registration Dates
First Submitted
November 15, 2022
First Submitted That Met QC Criteria
November 28, 2022
First Posted (Actual)
November 29, 2022
Study Record Updates
Last Update Posted (Actual)
November 29, 2022
Last Update Submitted That Met QC Criteria
November 28, 2022
Last Verified
November 1, 2022
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- RC31/22/0299
- 2022-A01799-34 (Other Identifier: ID-RCB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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