- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05880550
PCOS and US Cavitation
Response of Menstrual Irregularity and Infertility- Related Stress to Ultrasound Cavitation Combined With Aerobic Exercise in PCOS: Double Blinded Randomized Controlled Trial
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: marwa S saleh
- Phone Number: 01008342466
- Email: marwa_shafiek2000@yahoo.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria
All women in this study will be on the following criteria:
- Their ages will range from 20-35 years.
- They will be diagnosed with PCOS by Gynecologist.
- Doesn't receive any treatment for menstrual regularity and fertility during the study.
- BMI above 25kg/m²and less than 35kg/m².
- Waist /hip ratio <.88.
Exclusion Criteria
Women will be excluded if they have one of the following criteria:
- Skin diseases that prevent the application of cavitation.
- Severe cardiovascular disease.
- Other endocrine disordered (hypothyroidism hyperprolactinemia).
- Patients that who take hormonal treatment within the last 3 months before the study.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: control group
|
the patients will do aerobic training for 40 minutes on a bicycle ergometer.
|
Experimental: study group
|
Ultrasonic cavitation was turned on, the program of cavitation 40 kHz was chosen, the time was adjusted at 30 minutes. The cavitational head was moved very slowly on each abdominal segment in a small circular movement for 5 minutes. After finishing the focused ultrasound of the 6 segments of the abdomen, the skin was cleaned with cotton. in addition to that the patients will receive aerobic exercises for 40 minutes. |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Infertily related Stress level
Time Frame: change from base line at 12 weeks.
|
fertility problem inventory scale will be used for assessing the stress level pre and post treatment.
|
change from base line at 12 weeks.
|
cortisol level
Time Frame: change from base line at 12 weeks.
|
Saliva samples will be collected with study participants sitting upright in a comfortable position and tilting the head forward, allowing the saliva to pool on the floor of the mouth
|
change from base line at 12 weeks.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Anthrometric measurement (BMI And waist hip ratio)
Time Frame: change from base line at 12 weeks.
|
BMI and waist/hip ratio Measurements of BMI in which the weight in kilograms divided by the square of the heights in meters and waist to hip circumference measured with a soft tape at the level of the umbilicus and the anterior superior iliac spine with woman in the standing position, were made before treatment and after the end of the study period
|
change from base line at 12 weeks.
|
Hormonal profile (LH- FSH - LH /FSH ratio).
Time Frame: change from base line at 12 weeks.
|
Blood samples will be drown from an antecubital vein of each patient in the study on two occasions, firstly at the end at 2 nd or 3 rd day of the menstrual cycle after an overnight fasting just before starting her treatment regimen and secondly after 3 months of the treatment.
It will be centrifuged within 2 hours after withdrawal.
Serum will be stared at -20OC and assayed for LH and FSH with chemiluminescent enzyme immunoassay kits.
Assays for fasting insulin by RIA kits and SHBG will be determined by using an immunoradiometric assay (IRMA).
|
change from base line at 12 weeks.
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- US cavitation and PCOS
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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