Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[ConditionSearch] Connective Tissue Diseases
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#
NCTID/Status
Study
Last Changed
1
NCT03494036
Completed
Completed
Effect of Synbiotic on Immune Response, Gut Permeability and Microbiota in Patient With Connective Tissue Disease
Conditions: Connective Tissue Diseases
Intervention: Synbiotic, Placebo
Conditions: Connective Tissue Diseases
Intervention: Synbiotic, Placebo
March 10, 2019
2
NCT02234388
Recruiting
Recruiting
Undifferentiated Connective Tissue Disease Registry
Conditions: Undifferentiated Connective Tissue Disease
Intervention: Observation
Conditions: Undifferentiated Connective Tissue Disease
Intervention: Observation
April 8, 2019
3
NCT03565601
Recruiting
Recruiting
Prognostic Value of Anti-Ro52 Antibodies in Connective Tissue Diseases (a-Ro52)
Conditions: Connective Tissue Diseases
Intervention: Follow-up
Conditions: Connective Tissue Diseases
Intervention: Follow-up
December 6, 2019
4
NCT02657356
Active, not recruiting
Active, not recruiting
Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST
Conditions: Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Intervention: Placebo Capsules, Bardoxolone Methyl Capsules
Conditions: Connective Tissue Disease-Associated Pulmonary Arterial Hypertension
Intervention: Placebo Capsules, Bardoxolone Methyl Capsules
December 3, 2019
5
NCT01387035
Unknown status
Unknown status
Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases
Conditions: Connective Tissue Disease; Pulmonary Hypertension
Conditions: Connective Tissue Disease; Pulmonary Hypertension
July 1, 2014
6
NCT00864201
Unknown status
Unknown status
A Study to Evaluate the Use of Bosentan in Patients With Exercise Induced Pulmonary Arterial Hypertension Associated With Connective Tissue Disease
Conditions: Hypertension, Pulmonary; Connective Tissue Disease
Intervention: Bosentan
Conditions: Hypertension, Pulmonary; Connective Tissue Disease
Intervention: Bosentan
March 17, 2009
7
NCT03688191
Active, not recruiting
Active, not recruiting
Study of Sirolimus in CTD-TP in China
Conditions: Connective Tissue Diseases; Thrombocytopenia
Intervention: Sirolimus
Conditions: Connective Tissue Diseases; Thrombocytopenia
Intervention: Sirolimus
April 16, 2019
8
NCT03929120
Recruiting
Recruiting
Allogeneic Bone Marrow Mesenchymal Stem Cells for Patients With Interstitial Lung Disease (ILD) & Connective Tissue Disorders (CTD)
Conditions: Interstitial Lung Disease; Connective Tissue Diseases
Intervention: Allogeneic Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs)
Conditions: Interstitial Lung Disease; Connective Tissue Diseases
Intervention: Allogeneic Bone Marrow Derived Mesenchymal Stem Cells (BMD-MSCs)
November 26, 2019
9
NCT04095351
Not yet recruiting
Not yet recruiting
Connective Tissue Diseases and Lung Manifestations
Conditions: Connective Tissue Diseases; Interstitial Lung Disease; Systemic Sclerosis
Intervention: Pulmonary Function Test, Imaging, Blood Sampling
Conditions: Connective Tissue Diseases; Interstitial Lung Disease; Systemic Sclerosis
Intervention: Pulmonary Function Test, Imaging, Blood Sampling
September 18, 2019
10
NCT03671174
Recruiting
Recruiting
Immunosuppressant Regimens for Living Fetuses Study
Conditions: Undifferentiated Connective Tissue Disease; Recurrent Pregnancy Loss
Intervention: Prednisone, Hydroxychloroquine, Aspirin, Low Molecular Weight Heparin
Conditions: Undifferentiated Connective Tissue Disease; Recurrent Pregnancy Loss
Intervention: Prednisone, Hydroxychloroquine, Aspirin, Low Molecular Weight Heparin
August 8, 2019
11
NCT02688270
Completed
Completed
Efficacy and Safety of Vascana® in Subjects With Secondary Raynaud's Phenomenon
Conditions: Raynaud's Phenomenon Secondary to Connective Tissue Disease
Intervention: Vascana (0.9% Nitroglycerin Cream), Vehicle (placebo)
Conditions: Raynaud's Phenomenon Secondary to Connective Tissue Disease
Intervention: Vascana (0.9% Nitroglycerin Cream), Vehicle (placebo)
February 21, 2017
12
NCT02768259
Unknown status
Unknown status
Prevalence of Pulmonary Arterial Hypertension in Patients With Connective Tissue Diseases in Egyptian Patients
Conditions: Connective Tissue Diseases; Pulmonary Hypertension
Conditions: Connective Tissue Diseases; Pulmonary Hypertension
July 11, 2016
13
NCT02985437
Completed
Completed
Safety and Tolerability of Topically Applied Bovine Lung Surfactant on Intact Skin
Conditions: Skin and Connective Tissue Diseases
Intervention: Surfactants, Saline Solution
Conditions: Skin and Connective Tissue Diseases
Intervention: Surfactants, Saline Solution
September 6, 2017
14
NCT02379793
Completed
Completed
Skin Irritation Test of LEO 80185 Gel in Healthy Japanese Subjects
Conditions: Skin and Connective Tissue Diseases
Intervention: LEO 80185 Gel, Vehicle, Liquid Paraffin
Conditions: Skin and Connective Tissue Diseases
Intervention: LEO 80185 Gel, Vehicle, Liquid Paraffin
June 13, 2016
15
NCT00582881
Recruiting
Recruiting
Characteristics and Disease Progression of Mixed Connective Tissue Disease and Systemic Lupus Erythematosus
Conditions: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)
Conditions: Mixed Connective Tissue Disease (MCTD); Systemic Lupus Erythematosus (SLE)
June 17, 2019
16
NCT01862926
Recruiting
Recruiting
Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
Conditions: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease
Intervention: Rituximab, Cyclophosphamide
Conditions: Interstitial Lung Disease; Scleroderma; Idiopathic Inflammatory Myositis; Mixed Connective Tissue Disease
Intervention: Rituximab, Cyclophosphamide
March 25, 2019
17
NCT00001330
Completed
Completed
Study of Silicone-Associated Connective Tissue Diseases
Conditions: Autoimmune Diseases; Connective Tissue Diseases; Scleroderma, Circumscribed; Scleroderma, Systemic
Conditions: Autoimmune Diseases; Connective Tissue Diseases; Scleroderma, Circumscribed; Scleroderma, Systemic
March 3, 2008
18
NCT00341679
Completed
Completed
Studies of the Natural History and Pathogenesis of Autoimmune/Connective Tissue Diseases
Conditions: Autoimmune/Connective Tissue Diseases; Idiopathic Inflammatory Myopathies; Polymyositis; Dermatomyositis
Conditions: Autoimmune/Connective Tissue Diseases; Idiopathic Inflammatory Myopathies; Polymyositis; Dermatomyositis
November 22, 2019
19
NCT02518048
Completed
Completed
A Psoriasis Plaque Test Trial With LEO 90100 Compared to Betesil® in Patients With Psoriasis Vulgaris
Conditions: Skin and Connective Tissue Diseases
Intervention: LEO 90100 Aerosol Foam, Betesil® 2.25 Mg
Conditions: Skin and Connective Tissue Diseases
Intervention: LEO 90100 Aerosol Foam, Betesil® 2.25 Mg
May 1, 2017
20
NCT02355639
Completed
Completed
A Single-Centre Clinical Trial to Assess Steroid Induced Skin Atrophy on Healthy Skin
Conditions: Skin and Connective Tissue Diseases
Conditions: Skin and Connective Tissue Diseases
May 1, 2017
21
NCT02416258
Completed
Completed
A Psoriasis Plaque Test Trial With LP0113 Spray in Patients With Psoriasis Vulgaris (LP0113-1123)
Conditions: Skin and Connective Tissue Diseases
Intervention: LP0113 Aerosol Spray, Aerosol Spray Vehicle, LEO 90100 Aerosol Foam, Betamethasone Dipropionate Aerosol Spray, Calcipotriol Aerosol Spray, Daivobet® Gel
Conditions: Skin and Connective Tissue Diseases
Intervention: LP0113 Aerosol Spray, Aerosol Spray Vehicle, LEO 90100 Aerosol Foam, Betamethasone Dipropionate Aerosol Spray, Calcipotriol Aerosol Spray, Daivobet® Gel
May 1, 2017
22
NCT00802607
Completed
Completed
Collection of Tissue Specimens for Analysis and Establishment of Cell Cultures
Conditions: Bone Diseases; Connective Tissue Diseases
Conditions: Bone Diseases; Connective Tissue Diseases
June 30, 2017
23
NCT00522002
Completed
Completed
CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study
Conditions: Connective Tissue Diseases; Blood Coagulation Disorders; Leg Ulcers; Rheumatoid Arthritis; Systemic Lupus Erythematosus; Systemic Scleroderma; Mixed Connective Tissue Disease
Conditions: Connective Tissue Diseases; Blood Coagulation Disorders; Leg Ulcers; Rheumatoid Arthritis; Systemic Lupus Erythematosus; Systemic Scleroderma; Mixed Connective Tissue Disease
August 28, 2017
24
NCT00076830
Recruiting
Recruiting
Evaluation and Treatment of Patients With Connective Tissue Disease
Conditions: Connective Tissue Disorders; Osteogenesis Imperfecta; Bone Diseases, Metabolic
Conditions: Connective Tissue Disorders; Osteogenesis Imperfecta; Bone Diseases, Metabolic
December 5, 2019
25
NCT01683500
Completed
Completed
Calcinosis Cutis: Therapeutic Effects of Extracorporeal Shock Wave Therapy (ESWT)
Conditions: Calcinosis Cutis in Connective Tissue Disease
Intervention: Shock Wave Therapy With Modulith SLK (Storz)
Conditions: Calcinosis Cutis in Connective Tissue Disease
Intervention: Shock Wave Therapy With Modulith SLK (Storz)
June 2, 2015
26
NCT04179058
Not yet recruiting
Not yet recruiting
Interstitial Pneumonia With Autoimmune Features: Evaluation of Connective Tissue Disease Incidence During Follow-up
Conditions: Idiopathic Interstitial Pneumonia
Intervention: Follow-up
Conditions: Idiopathic Interstitial Pneumonia
Intervention: Follow-up
November 25, 2019
27
NCT01889966
Completed
Completed
VasoREACTivity Testing With Intravenous SILdenafil in Patients With Precapillary Pulmonary Hypertension
Conditions: Pulmonary Hypertension Associated With Connective Tissue Disease
Intervention: Sildenafil
Conditions: Pulmonary Hypertension Associated With Connective Tissue Disease
Intervention: Sildenafil
April 26, 2015
28
NCT03581162
Active, not recruiting
Active, not recruiting
Atherosclerosis in Juvenile Mixed Connective Tissue Disease (ACTID)
Conditions: Carotid Atherosclerosis
Intervention: Carotid Ultrasound And Venous Blood Sampling
Conditions: Carotid Atherosclerosis
Intervention: Carotid Ultrasound And Venous Blood Sampling
June 26, 2018
29
NCT02392130
Completed
Completed
A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin
Conditions: Skin Tissue Diseases; Connective Tissue Diseases
Intervention: Clobetasol Propionate 0.05% Ointment, LEO 130852A Gel 1%, LEO 130852A Placebo Gel
Conditions: Skin Tissue Diseases; Connective Tissue Diseases
Intervention: Clobetasol Propionate 0.05% Ointment, LEO 130852A Gel 1%, LEO 130852A Placebo Gel
May 1, 2017
30
NCT01468792
Completed
Completed
Hemodynamic Changes in Connective Tissue Disease
Conditions: Systemic Sclerosis
Conditions: Systemic Sclerosis
February 18, 2014
31
NCT01808196
Active, not recruiting
Active, not recruiting
Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD
Conditions: Eosinophilic Esophagitis; Connective Tissue Disorders
Intervention: Losartan Potassium
Conditions: Eosinophilic Esophagitis; Connective Tissue Disorders
Intervention: Losartan Potassium
January 25, 2018
32
NCT01424033
Terminated
Terminated
A Clinical Trial for CTD-ILD Treatment
Conditions: Interstitial Lung Disease; Connective Tissue Disease
Intervention: N-Acetylcysteine
Conditions: Interstitial Lung Disease; Connective Tissue Disease
Intervention: N-Acetylcysteine
February 22, 2017
33
NCT03446339
Recruiting
Recruiting
Pulmonary Hypertension Screening for Rheumatology Patients (SOPHIE)
Conditions: Connective Tissue Diseases; Systemic Sclerosis; Systemic Lupus Erythematosus
Conditions: Connective Tissue Diseases; Systemic Sclerosis; Systemic Lupus Erythematosus
July 11, 2019
34
NCT00491309
Unknown status
Unknown status
Exercise and Respiratory Therapy in Patients With Rheumatoid Arthritis / Collagenosis and Pulmonary Hypertension
Conditions: Pulmonary Hypertension; Connective Tissue Disease
Intervention: Exercise Training
Conditions: Pulmonary Hypertension; Connective Tissue Disease
Intervention: Exercise Training
July 1, 2014
35
NCT02255695
Completed
Completed
Effects of a School-based Exercise Program on Posture, Trunk Range of Motion, and Musculoskeletal Pain
Conditions: Musculoskeletal and Connective Tissue Disorders
Intervention: School-based Exercise Program
Conditions: Musculoskeletal and Connective Tissue Disorders
Intervention: School-based Exercise Program
September 29, 2014
36
NCT00001641
Completed
Completed
Study of Heritable Connective Tissue Disorders
Conditions: Connective Tissue Disease; Dissecting Aneurysm; Ehlers Danlos Syndrome; Marfan Syndrome; Nail Patella Syndrome
Conditions: Connective Tissue Disease; Dissecting Aneurysm; Ehlers Danlos Syndrome; Marfan Syndrome; Nail Patella Syndrome
March 3, 2008
37
NCT00005675
Completed
Completed
Oral Type I Collagen for Relieving Scleroderma
Conditions: Scleroderma; Connective Tissue Diseases
Intervention: Oral Bovine Type I Collagen, Placebo
Conditions: Scleroderma; Connective Tissue Diseases
Intervention: Oral Bovine Type I Collagen, Placebo
May 24, 2010
38
NCT01441076
Completed
Completed
Anakinra for Behcet s Disease
Conditions: Autoimmune Connective Tissue Disorder; Immune System Diseases
Intervention: Anakinra
Conditions: Autoimmune Connective Tissue Disorder; Immune System Diseases
Intervention: Anakinra
April 3, 2017
39
NCT02198651
Completed
Completed
A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects
Conditions: Rheumatoid Arthritis; Musculoskeletal and Connective Tissue Diseases
Intervention: Adalimumab, Placebo
Conditions: Rheumatoid Arthritis; Musculoskeletal and Connective Tissue Diseases
Intervention: Adalimumab, Placebo
June 6, 2019
40
NCT00147511
Completed
Completed
Time To Efficacy and Onset Of Action Of Linezolid
Conditions: Gram-Positive Bacterial Infections; Skin and Connective Tissue Diseases
Intervention: Linezolid
Conditions: Gram-Positive Bacterial Infections; Skin and Connective Tissue Diseases
Intervention: Linezolid
May 9, 2011
41
NCT04169100
Recruiting
Recruiting
Novel Form of Acquired Long QT Syndrome
Conditions: Long QT Syndrome; Connective Tissue Diseases; Rheumatoid Arthritis
Intervention: Prednisone
Conditions: Long QT Syndrome; Connective Tissue Diseases; Rheumatoid Arthritis
Intervention: Prednisone
November 15, 2019
42
NCT01488708
Terminated
Terminated
On Open-Label Study in Participants With Systemic Lupus Erythematosus
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
May 16, 2018
43
NCT01205438
Completed
Completed
A Study of LY2127399 in Participants With Systemic Lupus Erythematosus
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
Intervention: LY2127399, Placebo Every 2 Weeks, Placebo Every 4 Weeks
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
Intervention: LY2127399, Placebo Every 2 Weeks, Placebo Every 4 Weeks
June 18, 2018
44
NCT01196091
Completed
Completed
A Study of LY2127399 in Participants With Systemic Lupus Erythematosus
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
Intervention: LY2127399, Placebo Every 2 Weeks, Placebo Every 4 Weeks, Standard Of Care
Conditions: Systemic Lupus Erythematosus; Connective Tissue Disease; Autoimmune Disease
Intervention: LY2127399, Placebo Every 2 Weeks, Placebo Every 4 Weeks, Standard Of Care
June 11, 2018
45
NCT01809574
Unknown status
Unknown status
The Role of Rheumatological Evaluation in the Management of Patients With Interstitial Lung Disease
Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Connective Tissue Disease
Conditions: Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Connective Tissue Disease
April 8, 2015
46
NCT00270686
Completed
Completed
Studies of Heritable Disorders of Connective Tissue
Conditions: Ehlers-Danlos Syndrome; Stickler Syndrome; Marfan Syndrome
Conditions: Ehlers-Danlos Syndrome; Stickler Syndrome; Marfan Syndrome
April 4, 2018
47
NCT00001978
Recruiting
Recruiting
Determination of Kidney Function
Conditions: Kidney Disease; Proteinuria; Autoimmune / Connective Tissue Diseases
Conditions: Kidney Disease; Proteinuria; Autoimmune / Connective Tissue Diseases
October 26, 2019
48
NCT04171362
Recruiting
Recruiting
The Effect of Connective Tissue Massage in Patients With Migraine
Conditions: Migraine With Aura; Migraine; Migraine Without Aura; Connective Tissue Diseases
Intervention: Connective Tissue Massage, Education
Conditions: Migraine With Aura; Migraine; Migraine Without Aura; Connective Tissue Diseases
Intervention: Connective Tissue Massage, Education
November 19, 2019
49
NCT02494752
Unknown status
Unknown status
Role of Mesenchymal Stem Cells in Fat Grafting
Conditions: Romberg's Disease; Craniofacial Microsomia; Lipodystrophy; Mixed Connective Tissue Disease
Conditions: Romberg's Disease; Craniofacial Microsomia; Lipodystrophy; Mixed Connective Tissue Disease
July 9, 2015
50
NCT01764594
Completed
Completed
Safety Study of CDP7657 in Patients With Systemic Lupus Erythematosus
Conditions: Immune System Diseases; Autoimmune Diseases; Lupus Erythematosus, Systemic; Skin and Connective Tissue Diseases; Connective Tissue Disease
Intervention: CDP7657, Placebo
Conditions: Immune System Diseases; Autoimmune Diseases; Lupus Erythematosus, Systemic; Skin and Connective Tissue Diseases; Connective Tissue Disease
Intervention: CDP7657, Placebo
July 14, 2015
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Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
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Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
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Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
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Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.