Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[ConditionSearch] End-stage Heart Failure
#
NCTID/Status
Study
Last Changed
1
NCT02592499
Recruiting
Recruiting
Swedish Evaluation of Left Ventricular Assist Device as Permanent Treatment in End-stage Heart Failure
Conditions: End-stage Heart Failure
Intervention: HM III, OMM, Optimal Medical Management
Conditions: End-stage Heart Failure
Intervention: HM III, OMM, Optimal Medical Management
October 12, 2018
2
NCT03356353
Recruiting
Recruiting
Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation
Conditions: End Stage Heart Failure
Intervention: Sildenafil Citrate
Conditions: End Stage Heart Failure
Intervention: Sildenafil Citrate
December 9, 2019
3
NCT04117295
Not yet recruiting
Not yet recruiting
Carmat TAH Early Feasibility Study
Conditions: End-stage Heart Failure
Intervention: Carmat Total Artificial Heart
Conditions: End-stage Heart Failure
Intervention: Carmat Total Artificial Heart
October 9, 2019
4
NCT03966313
Not yet recruiting
Not yet recruiting
Perioperative Modification of Hemostasis During Ventricular Assist Device Implantation
Conditions: End-stage Heart Failure
Intervention: Ventricular Assist Device Implantation
Conditions: End-stage Heart Failure
Intervention: Ventricular Assist Device Implantation
May 28, 2019
5
NCT03923413
Completed
Completed
Endothelial Function and Circulating Microparticle in Patients Under LVAD Support
Conditions: End Stage Heart Failure
Intervention: Blood Samples
Conditions: End Stage Heart Failure
Intervention: Blood Samples
June 19, 2019
6
NCT02174133
Completed
Completed
Impact of LVAD Implantation on Micro- and Macrovascular Function
Conditions: End Stage Heart Failure
Conditions: End Stage Heart Failure
March 9, 2015
7
NCT01244321
Unknown status
Unknown status
COVADIS Pilot Trial: COseal in Ventricular Assist DevIceS
Conditions: End-stage Heart Failure Awaiting VAD Implantation
Conditions: End-stage Heart Failure Awaiting VAD Implantation
January 28, 2015
8
NCT00327782
Terminated
Terminated
Palliative Care of Children With End-Stage Heart Failure
Conditions: Congenital Disorders
Conditions: Congenital Disorders
May 2, 2007
9
NCT02086305
Completed
Completed
Transitional Palliative Care in End-stage Heart Failure
Conditions: End Stage Heart Disease; Heart Failure
Intervention: Transitional Care Model, Usual Care
Conditions: End Stage Heart Disease; Heart Failure
Intervention: Transitional Care Model, Usual Care
August 21, 2017
10
NCT00490321
Unknown status
Unknown status
VentrAssistTM LVAD for the Treatment of Advanced Heart Failure - Destination Therapy
Conditions: End-stage Heart Failure; Cardiomyopathies
Intervention: VentrAssistTM Left Ventricular Assist Device
Conditions: End-stage Heart Failure; Cardiomyopathies
Intervention: VentrAssistTM Left Ventricular Assist Device
September 4, 2009
11
NCT01759212
Active, not recruiting
Active, not recruiting
Left Ventricular Assist Device Combined With Allogeneic Mesenchymal Stem Cells Implantation in Patients With End-stage Heart Failure.
Conditions: Heart Failure; Ischemic Cardiomyopathy
Intervention: Allogeneic Stem Cells Implantation
Conditions: Heart Failure; Ischemic Cardiomyopathy
Intervention: Allogeneic Stem Cells Implantation
May 3, 2019
12
NCT00490347
Completed
Completed
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Feasibility Trial
Conditions: End-Stage Heart Failure; Cardiomyopathies
Intervention: VentrAssist Left Ventricular Assist Device
Conditions: End-Stage Heart Failure; Cardiomyopathies
Intervention: VentrAssist Left Ventricular Assist Device
January 15, 2008
13
NCT00483197
Unknown status
Unknown status
VentrAssistTM LVAD as a Bridge to Cardiac Transplantation - Pivotal Trial
Conditions: End-stage Heart Failure; Cardiomyopathies
Intervention: VentrAssistTM Left Ventricular Assist Device
Conditions: End-stage Heart Failure; Cardiomyopathies
Intervention: VentrAssistTM Left Ventricular Assist Device
September 4, 2009
14
NCT00383630
Terminated
Terminated
Bone Marrow Cell Transplantation to Improve Heart Function in Individuals With End-Stage Heart Failure
Conditions: Heart Failure, Congestive
Intervention: Intramyocardial Injection Of Bone Marrow Mononuclear Cells, Intramyocardial Injection Of CD34+ Selected Bone Marrow Mononuclear Cells, LVAD Alone
Conditions: Heart Failure, Congestive
Intervention: Intramyocardial Injection Of Bone Marrow Mononuclear Cells, Intramyocardial Injection Of CD34+ Selected Bone Marrow Mononuclear Cells, LVAD Alone
March 28, 2019
15
NCT03105726
Completed
Completed
Medical Care Versus Ventricular Assist Device for the Management of End-stage Heart Failure (MEVADE)
Conditions: Heart Failure; Heart Transplantation; Heart-Assist Devices
Conditions: Heart Failure; Heart Transplantation; Heart-Assist Devices
April 25, 2017
16
NCT02282683
Unknown status
Unknown status
Long-term Prednisone Use for End-stage Heart Failure
Conditions: Heart Failure; Hyperuricemia
Intervention: Prednisone
Conditions: Heart Failure; Hyperuricemia
Intervention: Prednisone
January 11, 2017
17
NCT04153890
Not yet recruiting
Not yet recruiting
Family Palliative and End-of-Life Care for Advanced Heart Failure
Conditions: Heart Failure NYHA Class III; Heart Failure NYHA Class IV
Intervention: FamPALcare
Conditions: Heart Failure NYHA Class III; Heart Failure NYHA Class IV
Intervention: FamPALcare
November 5, 2019
18
NCT02573207
Recruiting
Recruiting
Recovery of Hibernating Myocardium in End Stage Heart Failure
Conditions: Myocardial Function After LVAD Implant; Ischemic Cardiomyopathy
Conditions: Myocardial Function After LVAD Implant; Ischemic Cardiomyopathy
October 31, 2019
19
NCT00869024
Completed
Completed
Stem Cell Therapy in Patients With Severe Heart Failure & Undergoing Left Ventricular Assist Device Placement
Conditions: Heart Failure
Intervention: Intramyocardial Delivery Of Bone Marrow Derived Mononuclear Cells
Conditions: Heart Failure
Intervention: Intramyocardial Delivery Of Bone Marrow Derived Mononuclear Cells
February 7, 2017
20
NCT02344576
Unknown status
Unknown status
PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device
Conditions: Heart Failure; Heart-assist Devices
Intervention: DT LVAD Decision Support Intervention
Conditions: Heart Failure; Heart-assist Devices
Intervention: DT LVAD Decision Support Intervention
October 24, 2017
21
NCT00204802
Completed
Completed
Patient-Centered Advance Care Planning
Conditions: Heart Failure; Renal Failure
Intervention: Patient-Centered Advance Care Planning
Conditions: Heart Failure; Renal Failure
Intervention: Patient-Centered Advance Care Planning
October 1, 2015
22
NCT02248974
Completed
Completed
Development & Testing of a Decision Aid for LVAD Placement
Conditions: End-Stage Heart Failure; Bridge-to-Transplant LVAD Placement (BTT); Destination Therapy LVAD Placement (DT); Refusal of LVAD Placement (Decliners); LVAD Caregivers
Intervention: LVAD Decision Aid
Conditions: End-Stage Heart Failure; Bridge-to-Transplant LVAD Placement (BTT); Destination Therapy LVAD Placement (DT); Refusal of LVAD Placement (Decliners); LVAD Caregivers
Intervention: LVAD Decision Aid
February 14, 2019
23
NCT00678834
Completed
Completed
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol
Conditions: End Stage Cardiac Failure; Pulmonary Failure; End Stage Liver Disease; Morbid Obesity; Recalcitrant Epilepsy Requiring Surgery; Healthy Subjects
Intervention: To Surgery Patients, Tocopherol Capsules., Tocotrienol To Healthy Subjects., To Surgery Patients, Tocotrienol Capsules.
Conditions: End Stage Cardiac Failure; Pulmonary Failure; End Stage Liver Disease; Morbid Obesity; Recalcitrant Epilepsy Requiring Surgery; Healthy Subjects
Intervention: To Surgery Patients, Tocopherol Capsules., Tocotrienol To Healthy Subjects., To Surgery Patients, Tocotrienol Capsules.
September 8, 2014
24
NCT02858778
Unknown status
Unknown status
Timing of Acute Palliative Care Consultation in Critically Ill Patients
Conditions: Multiple Organ Failure; End Stage Cardiac Failure; End Stage Chronic Obstructive Airways Disease; Chronic Kidney Disease Stage 5; Hepatic Encephalopathy; Sepsis; Dementia; Multiple Sclerosis; Parkinson's Disease; In-Hospital Cardiac Arrest; Solid Organ Cancer
Intervention: Early Order Of Palliative Care Consultation
Conditions: Multiple Organ Failure; End Stage Cardiac Failure; End Stage Chronic Obstructive Airways Disease; Chronic Kidney Disease Stage 5; Hepatic Encephalopathy; Sepsis; Dementia; Multiple Sclerosis; Parkinson's Disease; In-Hospital Cardiac Arrest; Solid Organ Cancer
Intervention: Early Order Of Palliative Care Consultation
August 3, 2016
25
NCT00328809
Withdrawn
Withdrawn
Spironolactone Safety in Dialysis Patients
Conditions: End Stage Renal Disease; Congestive Heart Failure
Intervention: Spironolactone
Conditions: End Stage Renal Disease; Congestive Heart Failure
Intervention: Spironolactone
September 24, 2019
26
NCT03669198
Completed
Completed
A Health Economic Evaluation of Using N-Terminal Pro Brain Natriuretic Peptide (NT-Pro BNP) in Acute Heart Failure
Conditions: Heart Failure
Intervention: NT-Pro BNP
Conditions: Heart Failure
Intervention: NT-Pro BNP
September 12, 2018
27
NCT04061811
Completed
Completed
Soluble Neprilysin, NT-proBNP, and Growth-Differentiation-Factor-15 as Biomarkers for Heart Failure in Dialysis Patients
Conditions: Heart Failure; End Stage Renal Disease
Intervention: Diagnostic Biomarker Study
Conditions: Heart Failure; End Stage Renal Disease
Intervention: Diagnostic Biomarker Study
August 19, 2019
28
NCT02652676
Recruiting
Recruiting
Reversible Pulmonary Artery Banding as Simplified Management of End-stage Dilated Left Ventriculopathy in Early Life
Conditions: Acute on Chronic Systolic Congestive Heart Failure
Intervention: Reversible Pulmonary Artery Banding, GORE-TEX DualMesh EMERGE PLUS Biomaterial
Conditions: Acute on Chronic Systolic Congestive Heart Failure
Intervention: Reversible Pulmonary Artery Banding, GORE-TEX DualMesh EMERGE PLUS Biomaterial
March 19, 2019
29
NCT01427634
Completed
Completed
Proactive Palliative Care for Patients With Ventricular Assist Devices (VAD) and Their Families
Conditions: Heart Failure; End-stage Disease
Intervention: Palliative Care, Usual Care
Conditions: Heart Failure; End-stage Disease
Intervention: Palliative Care, Usual Care
September 5, 2013
30
NCT00402376
Terminated
Terminated
Evaluation of Myocardial Improvement in Patients Supported by Ventricular Assist Device Under Optimal Pharmacological Therapy
Conditions: Heart Failure
Intervention: Pravastatin, Carvedilol, Perindopril, Biventricular Assist Device (Thoratec Paracorporeal Assist Device)
Conditions: Heart Failure
Intervention: Pravastatin, Carvedilol, Perindopril, Biventricular Assist Device (Thoratec Paracorporeal Assist Device)
August 29, 2011
31
NCT01124227
Terminated
Terminated
Peritoneal Dialysis in Congestive Heart Failure
Conditions: Congestive Heart Failure
Intervention: Icodextrin
Conditions: Congestive Heart Failure
Intervention: Icodextrin
August 15, 2019
32
NCT03062176
Withdrawn
Withdrawn
Interleukin-1 Blockade for the Treatment of Heart Failure in Patients With Advanced Chronic Kidney Disease
Conditions: Heart Failure, Systolic; Renal Disease, End Stage; Chronic Kidney Diseases
Intervention: Anakinra
Conditions: Heart Failure, Systolic; Renal Disease, End Stage; Chronic Kidney Diseases
Intervention: Anakinra
May 15, 2019
33
NCT03341156
Recruiting
Recruiting
Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation
Conditions: Heart Disease End Stage; Heart Failureļ¼Congestive
Intervention: Kcentra, Frozen Plasma Product, Human
Conditions: Heart Disease End Stage; Heart Failureļ¼Congestive
Intervention: Kcentra, Frozen Plasma Product, Human
October 23, 2019
34
NCT01857999
Completed
Completed
Losartan in Decompensated Heart Failure
Conditions: Congestive Heart Failure; Low Cardiac Output
Intervention: Losartan, Placebo
Conditions: Congestive Heart Failure; Low Cardiac Output
Intervention: Losartan, Placebo
May 17, 2013
35
NCT02862197
Unknown status
Unknown status
Invasive Monitoring of Pulmonary Artery Pressure (PAP) Among Dialysis Treated Patients
Conditions: End Stage Renal Disease; Cardiac Insufficiency
Conditions: End Stage Renal Disease; Cardiac Insufficiency
August 21, 2017
36
NCT00391846
Completed
Completed
Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone
Conditions: Heart Failure; Ventricular Dysfunction, Left
Intervention: Captopril, Enalapril, Lisinopril, Ramipril, Trandolapril, Bisoprolol, Carvedilol, Metoprolol Succinate, Candesartan, Valsartan, Eplerenone, Spironolactone, Diuretics, HF Treatment According To Swedish Guidelines, Blood Samples, The Kansas City Cardiomyopathy Questionnaire (KCCQ)
Conditions: Heart Failure; Ventricular Dysfunction, Left
Intervention: Captopril, Enalapril, Lisinopril, Ramipril, Trandolapril, Bisoprolol, Carvedilol, Metoprolol Succinate, Candesartan, Valsartan, Eplerenone, Spironolactone, Diuretics, HF Treatment According To Swedish Guidelines, Blood Samples, The Kansas City Cardiomyopathy Questionnaire (KCCQ)
June 18, 2012
37
NCT03857633
Recruiting
Recruiting
MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure
Conditions: Myocardial Fibrosis; End Stage Renal Failure on Dialysis; Chronic Kidney Disease, Stage IV (Severe); Chronic Kidney Disease Stage V; Heart Failure
Intervention: Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast, Cardiac MRI 3 - With Gadolinium Contrast, Peripheral Whole Blood Samples
Conditions: Myocardial Fibrosis; End Stage Renal Failure on Dialysis; Chronic Kidney Disease, Stage IV (Severe); Chronic Kidney Disease Stage V; Heart Failure
Intervention: Cardiac MRI 1 - With Gadolinium Contrast, Cardiac MRI 2 - With Gadolinium Contrast, Cardiac MRI 3 - Without Gadolinium Contrast, Cardiac MRI 3 - With Gadolinium Contrast, Peripheral Whole Blood Samples
February 28, 2019
38
NCT00296543
Completed
Completed
T Wave Alternans in Hemodialysis
Conditions: End Stage Renal Disease; Coronary Heart Disease; Congestive Heart Failure
Conditions: End Stage Renal Disease; Coronary Heart Disease; Congestive Heart Failure
June 17, 2011
39
NCT02149316
Completed
Completed
Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery
Conditions: Myocardial Ischemic Reperfusion Injury; End Stage Heart Disease; Heart Failure; Cardiomyopathy
Intervention: RIPC+RIPostC, Control
Conditions: Myocardial Ischemic Reperfusion Injury; End Stage Heart Disease; Heart Failure; Cardiomyopathy
Intervention: RIPC+RIPostC, Control
December 22, 2016
40
NCT00858039
Completed
Completed
Cardiotoxicity of Adjuvant Trastuzumab
Conditions: Breast Neoplasms; Heart Failure
Conditions: Breast Neoplasms; Heart Failure
November 4, 2014
41
NCT01044290
Completed
Completed
Outlook Quality of Life Intervention Study
Conditions: Cancer; Congestive Heart Failure (CHF); Chronic Obstructive Pulmonary Disease (COPD); End Stage Renal Disease (ESRD)
Intervention: Life Completion, Attention Control
Conditions: Cancer; Congestive Heart Failure (CHF); Chronic Obstructive Pulmonary Disease (COPD); End Stage Renal Disease (ESRD)
Intervention: Life Completion, Attention Control
October 19, 2015
42
NCT01235182
Completed
Completed
Ultrasound in Acute Dyspnea in the Field
Conditions: Heart Failure; COPD; Asthma
Conditions: Heart Failure; COPD; Asthma
November 4, 2010
43
NCT02877446
Recruiting
Recruiting
South Of France Cardiac Assist Registry
Conditions: Chronic or Acute Advanced Heart Failure
Conditions: Chronic or Acute Advanced Heart Failure
August 18, 2016
Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.