Clinical Trials: SEARCH[Study] TILT[Study:StudyFirstPostDate] AREA[BasicSearch] Narcolepsy
#
NCTID/Status
Study
Last Changed
1
NCT02769780
Recruiting
Recruiting
A Web-based Observational Study of Patient-reported Outcomes in Adults With Narcolepsy
Conditions: Narcolepsy
Conditions: Narcolepsy
October 9, 2019
2
NCT02799849
Recruiting
Recruiting
Metabolism Characteristics in the Children With Narcolepsy
Conditions: Narcolepsy
Intervention: Sleep And Metabolism Assessment
Conditions: Narcolepsy
Intervention: Sleep And Metabolism Assessment
April 19, 2019
3
NCT01394614
Completed
Completed
Risk of Narcolepsy Associated With Administration of H1N1 Vaccine
Conditions: Narcolepsy
Conditions: Narcolepsy
May 12, 2015
4
NCT03267303
Completed
Completed
A Study to Evaluate the Safety and Efficacy of TS-091 in Patients With Narcolepsy
Conditions: Narcolepsy
Intervention: TS-091 5mg, TS-091 10mg, Placebo
Conditions: Narcolepsy
Intervention: TS-091 5mg, TS-091 10mg, Placebo
October 10, 2019
5
NCT00424931
Completed
Completed
A Safety and Effectiveness Study of a Single Dose of JNJ-17216498 in Patients With Narcolepsy
Conditions: Narcolepsy
Intervention: JNJ-17216498, JNJ-17216498, Modafinil
Conditions: Narcolepsy
Intervention: JNJ-17216498, JNJ-17216498, Modafinil
May 21, 2014
6
NCT02637076
Recruiting
Recruiting
July 30, 2019
7
NCT03378453
Completed
Completed
Narcolepsy Protect Against Alzheimer's Disease?
Conditions: Narcolepsy; Amyloid Pathology
Intervention: PET-scan18F-AV-45, PET-scan18F-AV-45
Conditions: Narcolepsy; Amyloid Pathology
Intervention: PET-scan18F-AV-45, PET-scan18F-AV-45
December 18, 2017
8
NCT01624480
Completed
Completed
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
Conditions: Narcolepsy
Intervention: Armodafinil
Conditions: Narcolepsy
Intervention: Armodafinil
December 8, 2015
9
NCT01638403
Completed
Completed
Effects of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy.
Conditions: Treatment of Excessive Daytime Sleepiness in Narcolepsy
Intervention: BF2.649, Vigil, Palcebo
Conditions: Treatment of Excessive Daytime Sleepiness in Narcolepsy
Intervention: BF2.649, Vigil, Palcebo
January 30, 2017
10
NCT04072380
Recruiting
Recruiting
A Study to Evaluate Safety, and Efficacy of SUVN-G3031 in Patients With Narcolepsy With and Without Cataplexy
Conditions: Narcolepsy
Intervention: SUVN-G3031, Placebo
Conditions: Narcolepsy
Intervention: SUVN-G3031, Placebo
October 10, 2019
11
NCT03754348
Recruiting
Recruiting
Microglial Activation in Narcolepsy Type 1: Positron Emission Tomography (PET) Study in [18F] DPA-714
Conditions: Narcolepsy 1
Conditions: Narcolepsy 1
May 16, 2019
12
NCT04096560
Not yet recruiting
Not yet recruiting
A Study of TAK-994 in Participants With Narcolepsy Type 1
Conditions: Narcolepsy Type 1
Intervention: TAK-994, Placebo
Conditions: Narcolepsy Type 1
Intervention: TAK-994, Placebo
September 18, 2019
13
NCT00366080
Terminated
Terminated
Effectiveness Of The Drug GSK189254 In Treating Patients With Narcolepsy
Conditions: Narcolepsy
Intervention: GSK189254
Conditions: Narcolepsy
Intervention: GSK189254
March 9, 2017
14
NCT00107796
Completed
Completed
Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
Conditions: Narcolepsy
Intervention: Modafinil
Conditions: Narcolepsy
Intervention: Modafinil
August 22, 2012
15
NCT03332784
Completed
Completed
Phase 1 TAK-925 Study in Healthy Adult and Elderly Volunteers and Patients With Narcolepsy
Conditions: Healthy Participants and Patients With Narcolepsy
Intervention: TAK-925, Placebo
Conditions: Healthy Participants and Patients With Narcolepsy
Intervention: TAK-925, Placebo
September 27, 2018
16
NCT02348593
Completed
Completed
"Twelve-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in Narcolepsy"
Conditions: Narcolepsy
Intervention: JZP-110, Placebo Oral Tablet
Conditions: Narcolepsy
Intervention: JZP-110, Placebo Oral Tablet
July 21, 2019
17
NCT03376568
Recruiting
Recruiting
Investigation of Clinical Feature and Brain Function in Narcoleptic Patients
Conditions: Narcolepsy; REM Sleep Behavior Disorder
Conditions: Narcolepsy; REM Sleep Behavior Disorder
December 15, 2017
18
NCT03748979
Completed
Completed
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAK-925 in Healthy Volunteers and Patients With Narcolepsy
Conditions: Healthy Participants; Narcolepsy
Intervention: TAK-925, Placebo
Conditions: Healthy Participants; Narcolepsy
Intervention: TAK-925, Placebo
October 29, 2019
19
NCT02452606
Unknown status
Unknown status
Clock and Narcolepsy Genetic Variants and the Effects of Stalevo® (Levodopa/Carbidopa/Entacapone) on Sleep Disorders in Parkinson's Disease
Conditions: Parkinson Disease; Sleep Disorders
Intervention: Stalevo®
Conditions: Parkinson Disease; Sleep Disorders
Intervention: Stalevo®
July 11, 2016
20
NCT01681121
Completed
Completed
A Study of the Safety and Effectiveness of ADX-N05 for Excessive Daytime Sleepiness in Subjects With Narcolepsy
Conditions: Narcolepsy
Intervention: ADX-N05, Placebo
Conditions: Narcolepsy
Intervention: ADX-N05, Placebo
September 15, 2014
21
NCT00066170
Completed
Completed
Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy
Conditions: Narcolepsy
Intervention: Xyrem, Xyrem Placebo, Modafinil At Established Dose, Modafinil (Placebo)
Conditions: Narcolepsy
Intervention: Xyrem, Xyrem Placebo, Modafinil At Established Dose, Modafinil (Placebo)
December 21, 2011
22
NCT03881852
Active, not recruiting
Active, not recruiting
Clinical Outcomes in Narcolepsy and Cataplexy: An Evaluation of Reboxetine Treatment (CONCERT)
Conditions: Narcolepsy; Cataplexy Narcolepsy; Excessive Sleepiness
Intervention: AXS-12 (Reboxetine), Placebo
Conditions: Narcolepsy; Cataplexy Narcolepsy; Excessive Sleepiness
Intervention: AXS-12 (Reboxetine), Placebo
October 28, 2019
23
NCT00107848
Completed
Completed
PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
Conditions: Narcolepsy; Sleep Apnea, Obstructive
Intervention: Modafinil
Conditions: Narcolepsy; Sleep Apnea, Obstructive
Intervention: Modafinil
May 8, 2014
24
NCT03626727
Recruiting
Recruiting
Evaluation of the Efficacy of Sodium Oxybate (Xyrem®) in Treatment of Post-traumatic Narcolepsy and Post-traumatic Hypersomnia
Conditions: Hypersomnia; Narcolepsy; Traumatic Brain Injury
Intervention: Sodium Oxybate Oral Solution [Xyrem]
Conditions: Hypersomnia; Narcolepsy; Traumatic Brain Injury
Intervention: Sodium Oxybate Oral Solution [Xyrem]
August 16, 2019
25
NCT00283894
Completed
Completed
Body Weight Regulation in Patients With Narcolepsy
Conditions: Narcolepsy
Conditions: Narcolepsy
October 5, 2017
26
NCT03433131
No longer available
No longer available
Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy
Conditions: Narcolepsy Without Cataplexy; Narcolepsy With Cataplexy
Intervention: Pitolisant
Conditions: Narcolepsy Without Cataplexy; Narcolepsy With Cataplexy
Intervention: Pitolisant
August 22, 2019
27
NCT01006122
Completed
Completed
A Study Of A Novel Compound For Excessive Daytime Sleepiness Associated With Narcolepsy
Conditions: Excessive Daytime Sleepiness; Narcolepsy
Intervention: Placebo, PF-03654746
Conditions: Excessive Daytime Sleepiness; Narcolepsy
Intervention: Placebo, PF-03654746
April 8, 2014
28
NCT00132873
Completed
Completed
Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy
Conditions: Narcolepsy
Intervention: Xyrem (sodium Oxybate) Oral Solution
Conditions: Narcolepsy
Intervention: Xyrem (sodium Oxybate) Oral Solution
September 18, 2013
29
NCT02806908
Recruiting
Recruiting
Study Assessing Effects of JZP-110 on Driving Performance in the Treatment of Excessive Sleepiness in Narcolepsy
Conditions: Narcolepsy; Excessive Sleepiness
Intervention: JZP-110, Placebo
Conditions: Narcolepsy; Excessive Sleepiness
Intervention: JZP-110, Placebo
March 12, 2018
30
NCT00078377
Completed
Completed
Safety and Efficacy Study of Armodafinil (CEP-10953) in the Treatment of Excessive Sleepiness Associated With Narcolepsy
Conditions: Narcolepsy
Intervention: Armodafinil, Armodafinil, Placebo
Conditions: Narcolepsy
Intervention: Armodafinil, Armodafinil, Placebo
July 12, 2013
31
NCT01399606
Completed
Completed
Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant)
Conditions: Narcolepsy; Cataplexy
Intervention: BF2.649
Conditions: Narcolepsy; Cataplexy
Intervention: BF2.649
January 30, 2017
32
NCT02512588
Completed
Completed
A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2
Conditions: Idiopathic Hypersomnia; Narcolepsy Without Cataplexy
Intervention: BTD-001, Placebo
Conditions: Idiopathic Hypersomnia; Narcolepsy Without Cataplexy
Intervention: BTD-001, Placebo
January 14, 2019
33
NCT03030599
Completed
Completed
A Study of the Efficacy and Safety of JZP-258 in Subjects With Narcolepsy With Cataplexy
Conditions: Narcolepsy With Cataplexy
Intervention: JZP-258, Placebo
Conditions: Narcolepsy With Cataplexy
Intervention: JZP-258, Placebo
September 5, 2019
34
NCT02348632
Completed
Completed
"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"
Conditions: Narcolepsy; Obstructive Sleep Apnea
Intervention: JZP-110
Conditions: Narcolepsy; Obstructive Sleep Apnea
Intervention: JZP-110
June 4, 2019
35
NCT02720744
Recruiting
Recruiting
Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy
Conditions: Excessive Daytime Sleepiness; Cataplexy; Narcolepsy
Intervention: Sodium Oxybate, Placebo
Conditions: Excessive Daytime Sleepiness; Cataplexy; Narcolepsy
Intervention: Sodium Oxybate, Placebo
September 25, 2019
36
NCT02221869
Completed
Completed
A Multicenter Study of the Efficacy and Safety of Xyrem With an Open- Label Pharmacokinetic Evaluation and Safety Extension in Pediatric Subjects With Narcolepsy With Cataplexy
Conditions: Narcolepsy With Cataplexy
Intervention: Xyrem
Conditions: Narcolepsy With Cataplexy
Intervention: Xyrem
April 26, 2019
37
NCT02077036
Unknown status
Unknown status
Narcolepsy - New Potential Treatment
Conditions: Narcolepsy
Intervention: Kinetic Oscillation Stimulation Device, Kinetic Oscillation Stimulation Device In Placebo Mode
Conditions: Narcolepsy
Intervention: Kinetic Oscillation Stimulation Device, Kinetic Oscillation Stimulation Device In Placebo Mode
February 28, 2014
38
NCT00214968
Completed
Completed
Assess the Safety and Effectiveness of PROVIGIL Treatment in Children and Adolescents With Excessive Sleepiness
Conditions: Narcolepsy
Intervention: Modafinil
Conditions: Narcolepsy
Intervention: Modafinil
May 23, 2012
39
NCT01485770
Completed
Completed
A Study of the Safety and Effectiveness of ADX-N05 in the Treatment of Excessive Daytime Sleepiness
Conditions: Narcolepsy
Intervention: ADX-N05, Placebo
Conditions: Narcolepsy
Intervention: ADX-N05, Placebo
April 5, 2016
40
NCT00228553
Completed
Completed
Extension Study of the Safety and Efficacy of Armodafinil in the Treatment of Patients With Excessive Sleepiness
Conditions: Excessive Daytime Sleepiness; Narcolepsy; Obstructive Sleep Apnea/Hypopnea Syndrome; Chronic Shift Work Sleep Disorder
Intervention: Armodafinil 100 To 250 Mg/day
Conditions: Excessive Daytime Sleepiness; Narcolepsy; Obstructive Sleep Apnea/Hypopnea Syndrome; Chronic Shift Work Sleep Disorder
Intervention: Armodafinil 100 To 250 Mg/day
July 12, 2013
41
NCT00078312
Completed
Completed
Armodafinil (CEP-10953) for Treatment of Narcolepsy, Obstructive Sleep Apnea/Hypopnea Syndrome, or Chronic Shift Work Sleep Disorder
Conditions: Narcolepsy; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Shift-Work Sleep Disorder
Intervention: CEP-10953 (Armodafinil)
Conditions: Narcolepsy; Sleep Apnea, Obstructive; Sleep Apnea Syndromes; Shift-Work Sleep Disorder
Intervention: CEP-10953 (Armodafinil)
July 12, 2013
42
NCT00049803
Completed
Completed
Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patients
Conditions: Narcolepsy
Intervention: Sodium Oxybate
Conditions: Narcolepsy
Intervention: Sodium Oxybate
June 23, 2005
43
NCT03772314
Recruiting
Recruiting
Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic Hypersomnia
Conditions: Idiopathic Hypersomnia; Narcolepsy Without Cataplexy
Intervention: Modafinil, Amphetamine-Dextroamphetamine
Conditions: Idiopathic Hypersomnia; Narcolepsy Without Cataplexy
Intervention: Modafinil, Amphetamine-Dextroamphetamine
April 15, 2019
44
NCT01067222
Completed
Completed
Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy
Conditions: Narcolepsy; Excessive Daytime Sleepiness; Cataplexy; Sleep Disorders
Intervention: BF2.649, Modafinil, Placebo
Conditions: Narcolepsy; Excessive Daytime Sleepiness; Cataplexy; Sleep Disorders
Intervention: BF2.649, Modafinil, Placebo
June 8, 2012
45
NCT03765892
Not yet recruiting
Not yet recruiting
Study of the Academic and Professional Course of Narcoleptic Patients (NARCOSCOL-NARCOVITAE)
Conditions: Narcolepsy
Intervention: Questionnaire (Adult), Questionnaire (Children)
Conditions: Narcolepsy
Intervention: Questionnaire (Adult), Questionnaire (Children)
December 4, 2018
46
NCT00228566
Completed
Completed
Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
Conditions: Excessive Daytime Sleepiness; Narcolepsy; Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Intervention: Armodafinil
Conditions: Excessive Daytime Sleepiness; Narcolepsy; Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS)
Intervention: Armodafinil
July 12, 2013
47
NCT01067235
Completed
Completed
Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy
Conditions: Narcolepsy; Cataplexy; Excessive Daytime Sleepiness
Intervention: BF2.649, BF2.649 Add On Modafinil
Conditions: Narcolepsy; Cataplexy; Excessive Daytime Sleepiness
Intervention: BF2.649, BF2.649 Add On Modafinil
February 8, 2013
48
NCT02611687
Recruiting
Recruiting
Efficacy and Safety of Pitolisant in Pediatric Narcoleptic Patients With or Without Cataplexy, Double-blind Study Followed by a Prolonged Open-label Period
Conditions: Narcolepsy With Cataplexy; Narcolepsy Without Cataplexy
Intervention: Pitolisant, Placebo
Conditions: Narcolepsy With Cataplexy; Narcolepsy Without Cataplexy
Intervention: Pitolisant, Placebo
November 28, 2018
49
NCT03173378
Completed
Completed
Evaluation of Academic and Professional Trajectories of Narcoleptic Patients
Conditions: Narcolepsy
Intervention: Questionnaires
Conditions: Narcolepsy
Intervention: Questionnaires
November 27, 2018
50
NCT00484757
Unknown status
Unknown status
Effect of Intranasal Administration of Orexine A on IL-6-System, Sleep-Wake-Regulation and Neurocognition
Conditions: Narcolepsy
Intervention: Orexine A
Conditions: Narcolepsy
Intervention: Orexine A
April 2, 2009
Last Updated
The last updated date is the most recent date when changes to a clinical trial were
submitted to ClinicalTrials.gov. There is often a delay of a few days before the
updated trial is available on the clinical trials website.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
First Received
The first received date is the date when the clinical trial was first submitted
to ClinicalTrials.gov. There is often a delay of a few days before the
trial is available on the clinical trials website.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.
Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.
Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.
Safety Issue
If selected, restricts search results to those studies which have
an outcome measure designated as a safety issue. Note that this is a
poor estimate of the safety of a treatment or intervention, but it is
all we have now.
Funded By
Studies are supported by one or more organizations called sponsors.
Support includes contributions of facilities, expertise, and/or financial resources.
All sponsors in the database have been assigned one of the following organization types:
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
National Institutes of Health (NIH)
Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.
Industry - the pharmaceutical companies
University/Organization - all others, including community-based organizations
Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.
Study Phase
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions
that study is seeking to answer:
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.
These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.
Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.
Age Group
Studies may be designed for participants of particular ages:
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Children (birth-17 yrs old)
Adults (18-65 yrs old)
Senior (66+ yrs old)
Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.
Gender
Searches can be restricted to studies which accept female or male participants.
Location Terms
If you are interested in a specific city (such as Los Angeles) or facility
name (such as the Mayo Clinic), enter it as a location term. Not all studies
include this level of detail, but if they do, this will find them.
Countries and States
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state.
Study IDs
Each trial is assigned one or more identification numbers by the institute, agency,
or organization sponsoring the trial. In addition, clinical trials assigns a
unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit.
Use this box to search for a trial by NCT identifier or any other study
identification numbers.
Examples:
Examples:
NCT00001789
97-h-0197
ia0006
actg 076
97-h-0197
ia0006
actg 076
Sponsor (Lead)
Use this box to specify the name of an institute, organization, or company that is
conducting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.
When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators
Use this box to specify institutes, organizations, or companies that are
conducting or otherwise supporting a trial.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.