ICH GCP | Clinical Trials Registry

Clinical Trials: SEARCH[STUDY] TILT[STUDY:STUDY-FIRST-POSTED] ( Retinopathies Neonates [STUDY:ALL-FIELDS] )



1 2 3 4 5 Last


#
NCTID/Status
Study
Last Changed
1
NCT03038295
Not yet recruiting
a Prospective Cohort Study for Propranolol Treatment in Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Propranolol, Placebo
February 1, 2017
2
NCT01079715
Completed
Safety and Efficacy of Propranolol in Newborns With Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Propranolol
November 24, 2012
3
NCT02014454
Completed
Safety and Efficacy of Propranolol Eye Drops in Treating Retinopathy of Premature
Conditions: Retinopathy of Prematurity
Intervention: Propranolol Eye Drops
July 6, 2015
4
NCT02102711
Completed
Oral Vitamin A Supplementation in Neonates With Birth Weight < 1500 g
Conditions: Bronchopulmonary Dysplasia; Retinopathy of Prematurity
Intervention: Vitamin A Oral Drops
March 21, 2019
5
NCT01875510
Completed
The Influence of Fish-oil Lipid Emulsions on Neonatal Morbidities
Conditions: Retinopathy of Prematurity; Neonatal Cholestasis
Intervention: Fish-oil Emulsions, Soybean-oil Emulsion
June 5, 2014
6
NCT02504944
Completed
Safety and Efficacy of Propranolol 0.2% Eye Drops in Treating Retinopathy of Premature: A Pilot Study (DROP-ROP-0.2%)
Conditions: Retinopathy of Prematurity
Intervention: Propranolol 0.2% Eye Drops
August 29, 2018
7
NCT01363960
Completed
Retinopathy of Prematurity:Summary of a Decade
Conditions: Retinopathy of Prematurity
May 31, 2011
8
NCT00895869
Completed
Pain in Neonates During Screening for Retinopathy of Prematurity Using Two Methods
Conditions: Retinopathy of Prematurity; Pain
February 24, 2010
9
NCT02820662
Completed
Study of the Implication of Omega-3 Polyunsaturated Fatty Acids in Retinopathy of Prematurity in New-born Infants
Conditions: Retinopathy of Prematurity
Intervention: RETCAM, Blood Samples
May 6, 2019
10
NCT01404247
Completed
Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates
Conditions: Retinal Diseases; Optic Nerve Diseases
Intervention: Observational: To Better Characterize The Retina And Optic Nerve In Newborns Using Spectral Domain Optical Coherence Tomography (s-oct)., OCT Imaging.
July 10, 2017
11
NCT02386839
Active, not recruiting
Long-term Safety and Efficacy Outcome Study Comparing Children Previously Enrolled in Study ROP-2008-01 for the Prevention of Retinopathy of Prematurity (ROP)
Conditions: Retinopathy of Prematurity (ROP)
March 25, 2019
12
NCT03830580
Recruiting
Benefit of Singing in the Care of Premature Children Undergoing Screening for Retinopathy of Prematurity in the Neonatology and Neonatal Resuscitation Unit of the Dijon University Hospital
Conditions: Prematurity; Eye Fundus
Intervention: Positive Stimulation (singing)
April 16, 2019
13
NCT03824782
Completed
The Effect of Eyemasks on Neonatal Stress Following Dilated Retinal Examination
Conditions: Retinopathy of Prematurity; Pain; Premature Infant; Retinal Disease
Intervention: Phototherapy Mask
January 29, 2019
14
NCT02814929
Completed
Incidence, Risk Factors and Severity of Retinopathy of Prematurity (ROP) in Turkey
Conditions: Retinopathy of Prematurity
October 18, 2017
15
NCT01559571
Active, not recruiting
Registry for Severe ROP and Treatment on Visual Outcomes
Conditions: Retinopathy of Prematurity
August 12, 2019
16
NCT02152046
Enrolling by invitation
ROP Screening: Comparison of Pain Using Two Eyelid Retractors
Conditions: Pain During ROP Exam
Intervention: ROP Exam With Spring Loaded Retractor, ROP Exam With Screw Retractor
January 22, 2019
17
NCT02959229
Completed
Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis
Conditions: Neonatal Sepsis
Intervention: Lactoferrin, Placebo (for Lactoferrin)
November 5, 2016
18
NCT01954082
Terminated
Inositol to Reduce Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity (ROP)
Intervention: Myo-Inositol 5% Injection, Placebo
March 20, 2019
19
NCT00648687
Completed
Pain Response During Examination for Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Suck 12.5% Dextrose In Water 5 Minutes Before The Procedure
July 21, 2010
20
NCT01266824
Terminated
Proparacaine and Mydriatic Eye Drops
Conditions: Pain; Retinopathy of Prematurity
Intervention: Proparacaine Hydrochloride Ophthalmic Solution
February 15, 2013
21
NCT01203436
Completed
Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity
Conditions: Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Retinopathy of Prematurity; Blindness
Intervention: Supplemental Oxygen Management, Conventional Oxygen Management
June 3, 2015
22
NCT01306227
Completed
L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia
Conditions: Hypothyroxinemia
Intervention: L-Thyroxine, Water
August 9, 2018
23
NCT03154723
Completed
Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants
Conditions: Retinopathy of Prematurity
Intervention: Vitamin A
August 31, 2018
24
NCT00349726
Completed
Single-Dose Intravenous Inositol Pharmacokinetics in Preterm Infants
Conditions: Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Retinopathy of Prematurity; Bronchopulmonary Dysplasia (BPD)
Intervention: Inositol Lower Volume, Inositol Higher Volume, Placebo Lower Volume, Placebo Higher Volume
June 19, 2017
25
NCT00921544
Completed
Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Conditions: Retinopathy of Prematurity
Intervention: Sucrose, Sterile Water
June 15, 2009
26
NCT03347799
Completed
WINROP Algorithm Validation for Retinopathy Screening in a Cohort of Premature Infants
Conditions: Retinopathy of Prematurity
November 16, 2017
27
NCT03757871
Recruiting
Contribution of Acupuncture on Pain Related to the Screening of Premature Retinopathy (ROP) by Digital Camera
Conditions: Laser Stimulation
Intervention: Laser Stimulation
July 8, 2019
28
NCT02134457
Completed
Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity (ROP)
Intervention: Ranibizumab
March 8, 2017
29
NCT01861470
Completed
REDEXAM - Reducing Painful Eye Examinations in Preterm Infants
Conditions: Retinopathy of Prematurity
October 7, 2015
30
NCT02484989
Completed
UK Surveillance of Treated Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Surviellance Card
March 15, 2016
31
NCT03340103
Recruiting
Early Administration of the Lutein/Zeaxanthin in Premature Newborns
Conditions: Antioxidant Role of the Lutein in Preterm Newborn
Intervention: LUTEIN Ofta 0,5 Gocce, Placebo
November 10, 2017
32
NCT01773746
Terminated
Study of Room Air Versus 60% Oxygen for Resuscitation of Premature Infants
Conditions: Extreme Prematurity - Less Than 28 Weeks
Intervention: Neonatal Resuscitation
September 10, 2018
33
NCT02050971
Unknown status
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
Conditions: Anemia, Neonatal; Intracranial Hemorrhages; Necrotizing Enterocolitis; Respiratory Distress Syndrome, Newborn; Retinopathy of Prematurity; Bronchopulmonary Dysplasia
Intervention: Umbilical Cord Blood Infusion, Intravenous Infusion Of Peripheral Blood Or Its Components
January 30, 2014
34
NCT03083431
Not yet recruiting
Oral Propranolol for Prevention of Threshold Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Propranolol, Placebo
July 22, 2019
35
NCT01030575
Completed
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
Conditions: Infant, Newborn; Infant, Low Birth Weight; Infant, Small for Gestational Age; Infant, Premature; Retinopathy of Prematurity; Bronchopulmonary Dysplasia (BPD)
Intervention: Inositol Lower Volume, Inositol Mid-level Volume, Inositol High Volume, Placebo Low Volume
March 20, 2019
36
NCT02375971
Completed
RAINBOW Study: RAnibizumab Compared With Laser Therapy for the Treatment of INfants BOrn Prematurely With Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Ranibizumab, Laser Therapy
October 15, 2018
37
NCT00702819
Terminated
Pan-VEGF Blockade for the Treatment of Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Bevacizumab
January 26, 2010
38
NCT00500396
Completed
Vascular Endothelial Growth Factor in Stage V ROP
Conditions: Retinopathy of Prematurity
Intervention: Open-Sky Vitrectomy
November 21, 2007
39
NCT02853253
Withdrawn
Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide
Conditions: Preterm Neonates
Intervention: SMOFlipid®, Medialipide®
July 22, 2019
40
NCT00642135
Terminated
CLAIR -FO: Clinical Trial of Ophthalmic Insert Mydriasert® Versus Reference Treatment
Conditions: Retinal Anomalies; Premature Birth
Intervention: Mydriasert®, Phenylephrine And Tropicamide Eyedrops
April 9, 2008
41
NCT03581214
Recruiting
Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Conditions: Intrauterine Resuscitation
Intervention: No Oxygen, Oxygen
October 22, 2018
42
NCT03253263
Recruiting
A Clinical Efficacy and Safety Study of SHP607 in Preventing Chronic Lung Disease in Extremely Premature Infants
Conditions: Retinopathy of Prematurity (ROP); Intraventricular Hemorrhage; Bronchopulmonary Dysplasia; Chronic Lung Disease of Prematurity
Intervention: SHP607
May 29, 2019
43
NCT02887157
Recruiting
Analyzing Retinal Microanatomy in ROP
Conditions: Retinopathy of Prematurity; Neurodevelopmental Disorders; Macular Edema
Intervention: Swept Source OCT, Magnetic Resonance Imaging, Scavenged Blood Collection
December 12, 2018
44
NCT00339001
Unknown status
Erythropoietin and Early Iron Supplement and Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity
Intervention: Erythropoietin And Early Iron Supplements
June 19, 2006
45
NCT00326924
Completed
Age of Red Blood Cells in Premature Infants Study (ARIPI)
Conditions: Premature Birth
Intervention: Transfusion
January 17, 2018
46
NCT00623220
Completed
Inhaled Nitrous Oxide for Pain Relief During Eye Exam in the Pre-term Infant
Conditions: Retinopathy of Prematurity
Intervention: N2O, Oxygen
October 28, 2013
47
NCT02977000
Unknown status
Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants
Conditions: Retinopathy of Prematurity
Intervention: Propranolol
November 29, 2016
48
NCT03650621
Recruiting
Magnetic Non-Invasive Acupuncture For Infant Comfort A Pilot Study in Preterm Infants Requiring Eye-exam for Retinopathy of Prematurity
Conditions: Retinopathy of Prematurity; Pain; Acupuncture; Premature Infant
Intervention: Magnetic Acupuncture, Stickers (magnets Removed)
April 11, 2019
49
NCT03596125
Recruiting
Correction of Neonatal Glutathione by N-acetylcysteine in Pregnant Women at Risk of Premature Birth (GSH MAP)
Conditions: Preterm Delivery
Intervention: N-acetylcysteine, Placebo
July 9, 2019
50
NCT00563121
Completed
VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and V
Conditions: Retinopathy of Prematurity
Intervention: Vitrectomy
November 23, 2007

1 2 3 4 5 Last


Last Updated

The last updated date is the most recent date when changes to a clinical trial were submitted to ClinicalTrials.gov. There is often a delay of a few days before the updated trial is available on the clinical trials website.

Specify a From date to find the most recently changed trials. Specify both From and To dates to find trials changed during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

First Received

The first received date is the date when the clinical trial was first submitted to ClinicalTrials.gov. There is often a delay of a few days before the trial is available on the clinical trials website.

Clinical trial records are often updated after they have been published. The first received, last updated, start, and end dates are all displayed in the full text view of the clinical trial.

Specify a From date to find the most recent trials. Specify both From and To dates to find trials submitted during a certain period. If no dates are given, all trials will be included.

Dates should be given in a MM/DD/YYYY format, as in 1/1/2006 or 8/17/2004.

Safety Issue

If selected, restricts search results to those studies which have an outcome measure designated as a safety issue. Note that this is a poor estimate of the safety of a treatment or intervention, but it is all we have now.

Funded By

Studies are supported by one or more organizations called sponsors. Support includes contributions of facilities, expertise, and/or financial resources. All sponsors in the database have been assigned one of the following organization types:

National Institutes of Health (NIH)

Other U.S. Federal Agency - Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), Department of Veterans Affairs (VA), etc.

Industry - the pharmaceutical companies

University/Organization - all others, including community-based organizations

Click the check box to the left of each organization type that you wish to include in your search. You can select more than one organization type. If you do not select any type, all types will be included.

Study Phase

Most clinical trials are designated as phase 1, 2, 3, or 4, based on the type of questions that study is seeking to answer:

In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.

In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.

In Phase 3 (Phase III) clinical trials, the study drug or treatment is given to large groups of people (1,000-3,000) to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.

In Phase 4 (Phase IV) clinical trials, post marketing studies delineate additional information including the drug's risks, benefits, and optimal use.

These phases are defined by the Food and Drug Administration in the Code of Federal Regulations.

Click the check box to the left of each study phase that you wish to include in your search. You can select more than one study phase. If you do not select a any phase, all phases will be included.

Age Group

Studies may be designed for participants of particular ages:

Children (birth-17 yrs old)

Adults (18-65 yrs old)

Senior (66+ yrs old)

Click the check box to the left of each age group that you wish to include in your search. You can select more than one age group. If you do not select a any group, all groups will be included.

Gender

Searches can be restricted to studies which accept female or male participants.
Location Terms

If you are interested in a specific city (such as Los Angeles) or facility name (such as the Mayo Clinic), enter it as a location term. Not all studies include this level of detail, but if they do, this will find them.

Countries and States

Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state.

Study IDs

Each trial is assigned one or more identification numbers by the institute, agency, or organization sponsoring the trial. In addition, clinical trials assigns a unique NCT identifier of the form NCTxxxxxxxx where each x is a numeric digit. Use this box to search for a trial by NCT identifier or any other study identification numbers.

Examples:

NCT00001789
97-h-0197
ia0006
actg 076

Sponsor (Lead)

Use this box to specify the name of an institute, organization, or company that is conducting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

A search in this area will check only the sponsor field. To also look for collaborators, use the Sponsor/Collaborators search box.

When the Exact Match checkbox is checked, the sponsor name in the study must exactly match the sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Sponsor/Collaborators

Use this box to specify institutes, organizations, or companies that are conducting or otherwise supporting a trial.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.

Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.

When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Examples:

National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb

Outcome Measures

Outcome measures are used to evaluate trial results. For example, an obesity treatment might be evaluated by a measure of weight loss after 6 months. Measures can also be used to quantify side effects, such as number of myocardial infarctions, number of patients with heart arrhythmia, number of suicides, etc.

Use this box to specify an outcome measure used to evaluate trial results.

Examples:

weight loss
heart failure
suicide

Interventions

Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied. Interventions can also include less intrusive possibilities such as surveys, education, and interviews.

Use this box to specify drugs, devices, procedures, or vaccines used in a trial.

Examples:

clofibrate
cyclosporine
vitamin e

Conditions

Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov, conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.

Use this box to specify the conditions being studied.

Examples:

lupus
heart attack
leukemia
risk factors for breast cancer

Study Type

There are three types of studies available in ClinicalTrials.gov:

Interventional:

Studies where individuals are assigned to receive specific interventions. Participants may receive diagnostic, therapeutic or other types of interventions. Assignment of the intervention may or may not be random. Individuals are tracked and biomedical and/or health outcomes are assessed.

Observational:

Studies without an intervention. Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals. Participants may receive diagnostic, therapeutic, or other interventions, but the investigator does not assign specific interventions to the participants of the study.

Expanded Access:

Records describing the procedure for obtaining an experimental drug or device for patients who are failing on currently available treatments for their condition and also are unable to participate in ongoing clinical trials. Expanded Access records are used to register all types of non-protocol access to experimental treatments, including protocol exception, single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.

Study Results

Searches can be restricted to studies with or without results.

The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.

Recruitment Status

Also known as Enrollment Status.

Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.

If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.

Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.

Full list of all possible recruitment status values:

Open recruitment status values:

Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:

Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Search Terms

Use this box to specify general search terms found anywhere in the trial record.

Multiple terms can be separated by an AND (all uppercase).

Examples:

type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study


Help for Searching clinical trials

Help Topics:
Basic Search
Advanced Search
Refine Search
Search Expressions


Basic Search:

On the Basic Search page, enter a word or word(s) that you want to use to find studies. These may include diseases, interventions, and/or locations.

Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks

A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.


Advanced Search:

Many searches are a single term and can be performed with a few words in the search box. But, sometimes you need more control. Click on the Advanced Search tab (if starting a new search) or Refine Search tab (if modifying an existing search) to show additional search fields.

The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.

Search Terms:
Performs a general search in all sections of the study record, including title, description, conditions, interventions, locations, etc. Terms in this field are searched the same as Basic Search.

Recruitment:
Limits search results to studies that are open or closed. New volunteers may be able to participate in open studies, but not closed studies.

Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.

Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.

Values are color coded (as shown) in the search results.

Study Results:
Limits search results based on whether the study has results or not:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov. Only a few studies have results available.

Study Type:
Limits search results to any of the following study types:
Interventional,
Observational, or
Expanded Access

Conditions:
Performs a search on fields describing the diseases or conditions being studied.

Interventions:
Performs a search on fields listing the drugs or interventions being studied.

Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.

Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.

When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Sponsor (Lead):
Performs a search on the sponsor field of a study.

It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.

When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.

Study IDs:
Performs a search on fields listing ID numbers.

Country/State:
Trials are often conducted at many locations around the world. Select up to three locations to find trials conducted in specific countries. Some countries (currently limited to the United States, Canada, and Australia), locations can be narrowed further by selecting a state (e.g., United States, Alabama).

Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic). Not all studies include this level of detail, but if they do, this will find them.

Gender:
Limits search results to those studies that accept female or male participants.

Age Group:
Limits search results to those studies that include at least one of the specified age ranges. More than one age group can be selected.

Phase:
Limits search results to studies that are labeled with at least one of the specified phases. More than one Phase can be selected.

Funded By:
Limits search results to studies that have at least one sponsor of the specified types. More than one sponsor type can be selected.

Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.

First Received:
Limits search results to studies that were received by clinical trials within a specified date range. The "From" or "To" field can be left blank.

Last Updated:
Limits search results to studies that were modified within a specified date range. The "From" or "To" field can be left blank.


Refine Search:

Searches display a list of studies found (List Results tab). If you are not content with the search results, click on the Refine Search tab at the top of the list to modify your search.

Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.

For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California

When you are done making changes, click Search to display the new results.


Search Expressions:

Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California

Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack

Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS

Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )

Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.

To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.

Conditions

Alphabetic (A-Z)
By Category

Rare Diseases

Alphabetic (A-Z)

Drug
Interventions

Alphabetic (A-Z)
By Category

Dietary
Supplements

Alphabetic (A-Z)
By Category

Sponsor/
Collaborators

Alphabetic (A-Z)
By Category

Locations

Alphabetic (A-Z)
By Category